Jukka Rantanen
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View article: Effect of amino acids on the compaction behavior and stability of spray-dried trypsin/lactose powder
Effect of amino acids on the compaction behavior and stability of spray-dried trypsin/lactose powder Open
Amino acids (AAs) have been employed as excipients in spray-dried (SD) protein formulations due to their stabilizing effects and particle engineering abilities. However, the research focusing on the influence of AAs on the tabletability of…
View article: In-line monitoring of tablet compression with terahertz time-domain spectroscopy for physical tablet characteristics
In-line monitoring of tablet compression with terahertz time-domain spectroscopy for physical tablet characteristics Open
Process analysers integrated in process analytical technology (PAT) systems are now well-established in the pharmaceutical industry. These sensors play a crucial role in advancing manufacturing science by enabling robust process designs al…
View article: Visualization and quantification of citalopram hydrobromide within highly porous drug products by near-infrared chemical imaging
Visualization and quantification of citalopram hydrobromide within highly porous drug products by near-infrared chemical imaging Open
A novel method for the fabrication of flexible and precise doses of an antidepressant, citalopram hydrobromide (CHB), utilizing two approaches of incorporating CHB into the dosage form, was introduced in an earlier study. This method, call…
View article: Impact of additives on the long-term physical stability of antidepressant citalopram hydrobromide in personalized drug delivery systems
Impact of additives on the long-term physical stability of antidepressant citalopram hydrobromide in personalized drug delivery systems Open
This study aimed to investigate the effect of the manufacturing process, composition, and storage on the long-term physical stability of antidepressant citalopram hydrobromide (CHB) in oral solid foams as personalized drug delivery systems…
View article: Insight into manufacturing of bespoke combination drug products containing carvedilol and simvastatin by fused deposition modeling
Insight into manufacturing of bespoke combination drug products containing carvedilol and simvastatin by fused deposition modeling Open
The goal of this study was to explore the fabrication of a combination drug product containing two poorly soluble active pharmaceutical ingredients (APIs), carvedilol (CAR) and simvastatin (SIM), in therapeutically relevant doses (25 mg of…
View article: Using density changes to monitor blending with magnesium stearate by terahertz time-domain spectroscopy
Using density changes to monitor blending with magnesium stearate by terahertz time-domain spectroscopy Open
Magnesium stearate (MgSt) is among the most common excipients and the most common lubricant in solid oral products. It is primarily added to tablet formulations to ease ejection during tablet compression. While commonly present in low conc…
View article: Understanding the complexity of near-infrared quantification of highly porous patient-tailored drug products by utilizing chemometrics and stimulated Raman imaging
Understanding the complexity of near-infrared quantification of highly porous patient-tailored drug products by utilizing chemometrics and stimulated Raman imaging Open
Additively manufactured drug products, typically produced using small-scale, on-demand batch mode, require rapid and non-destructive quantification methods. A tunable modular design (TMD) approach combining porous polymeric freeze-dried mo…
View article: Exploring the hydrate landscape using data mining on the Cambridge structural database (CSD)
Exploring the hydrate landscape using data mining on the Cambridge structural database (CSD) Open
With the continued relevance of drug hydrates in pharmaceutical sciences, a comprehensive understanding of hydrate and anhydrate forms is essential, not only through individual case studies but also from a broader, systematic perspective. …
View article: THz-TDS as a PAT tool for monitoring blend homogeneity in pharmaceutical manufacturing of solid oral dosage forms: A proof-of-concept study
THz-TDS as a PAT tool for monitoring blend homogeneity in pharmaceutical manufacturing of solid oral dosage forms: A proof-of-concept study Open
The process analytical technology (PAT) framework is well established and integral to facilitate process understanding, enable a transition from batch to continuous manufacturing, and improve product quality. Near-infrared (NIR) spectrosco…
View article: Amino acids as stabilizers for lysozyme during the spray-drying process and storage
Amino acids as stabilizers for lysozyme during the spray-drying process and storage Open
Amino acids (AAs) have been used as excipients in protein formulations both in solid and liquid state products due to their stabilizing effect. However, the mechanisms by which they can stabilize a protein have not been fully elucidated ye…
View article: Tailor‐Made Doses of Pharmaceuticals by Tunable Modular Design: A Case Study on Tapering Antidepressant Medication
Tailor‐Made Doses of Pharmaceuticals by Tunable Modular Design: A Case Study on Tapering Antidepressant Medication Open
An abrupt cessation of antidepressant medication can be challenging due to the appearance of withdrawal symptoms. A slow hyperbolic tapering of an antidepressant, such as citalopram hydrobromide (CHB), can mitigate the withdrawal syndrome.…
View article: Compaction Properties of Particulate Proteins in Binary Powder Mixtures with Common Excipients
Compaction Properties of Particulate Proteins in Binary Powder Mixtures with Common Excipients Open
The increasing interest in protein- and peptide-based oral pharmaceuticals has culminated in the first protein-based products for oral delivery becoming commercially available. This study investigates the compaction properties of proteins …
View article: Binder jetting 3D printing in fabricating pharmaceutical solid products for precision medicine
Binder jetting 3D printing in fabricating pharmaceutical solid products for precision medicine Open
Current treatment strategies are moving towards patient‐centricity, which emphasizes the need for new solutions allowing for medication tailored to a patient. This can be realized by precision medicine where patient diversity is considered…
View article: Solid-state analysis for pharmaceuticals: Pathways to feasible and meaningful analysis
Solid-state analysis for pharmaceuticals: Pathways to feasible and meaningful analysis Open
The solid state of matter is the preferred starting point for designing a pharmaceutical product. This is driven by both patient preferences and the relative ease of supplying a solid pharmaceutical product with desired quality and perform…
View article: CCDC 2125037: Experimental Crystal Structure Determination
CCDC 2125037: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: The structure of magnesium stearate trihydrate determined from a micrometre-sized single crystal using a microfocused synchrotron X-ray beam
The structure of magnesium stearate trihydrate determined from a micrometre-sized single crystal using a microfocused synchrotron X-ray beam Open
Crystalline magnesium stearate has been extensively used as an additive in pharmaceutical and other industries for decades. However, the lack of suitably large crystals has hindered the determination of the crystal structure and thereby a …
View article: Exploring the Solid-State Landscape of Carbamazepine during Dehydration: A Low Frequency Raman Spectroscopy Perspective
Exploring the Solid-State Landscape of Carbamazepine during Dehydration: A Low Frequency Raman Spectroscopy Perspective Open
The solid-state landscape of carbamazepine during its dehydration was explored using Raman spectroscopy in the low- (−300 to −15, 15 to 300) and mid- (300 to 1800 cm−1) frequency spectral regions. Carbamazepine dihydrate and forms I, III, …
View article: Co-administration of Intravenous Drugs: Rapidly Troubleshooting the Solid Form Composition of a Precipitate in a Multi-drug Mixture Using On-Site Raman Spectroscopy
Co-administration of Intravenous Drugs: Rapidly Troubleshooting the Solid Form Composition of a Precipitate in a Multi-drug Mixture Using On-Site Raman Spectroscopy Open
Intravenous drugs are often co-administrated in the same intravenous catheter line due to which compatibility issues, such as complex precipitation processes in the catheter line, may occur. A well-known example that led to several neonata…
View article: Compaction Behavior of Co-Amorphous Systems
Compaction Behavior of Co-Amorphous Systems Open
Co-amorphous systems have been shown to be a promising strategy to address the poor water solubility of many drug candidates. However, little is known about the effect of downstream processing-induced stress on these systems. The aim of th…
View article: Role of dispersion enhancer selection in the development of novel tratinterol hydrochloride dry powder inhalation formulations
Role of dispersion enhancer selection in the development of novel tratinterol hydrochloride dry powder inhalation formulations Open
Tratinterol hydrochloride (TH) is a new long-acting bronchodilator with strong β2 adrenoceptor stimulation activity. The aim of this study was to design a new carrier-based dry powder inhalation (DPI) formulation for TH and to investigate …
View article: CCDC 2162581: Experimental Crystal Structure Determination
CCDC 2162581: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2162580: Experimental Crystal Structure Determination
CCDC 2162580: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Mucoadhesive chitosan- and cellulose derivative-based nanofiber-on-foam-on-film system for non-invasive peptide delivery
Mucoadhesive chitosan- and cellulose derivative-based nanofiber-on-foam-on-film system for non-invasive peptide delivery Open
Oromucosal administration is an attractive non-invasive route. However, drug absorption is challenged by salivary flow and the mucosa being a significant permeability barrier. The aim of this study was to design and investigate a multi-lay…
View article: Coating of Primary Powder Particles Improves the Quality of Binder Jetting 3D Printed Oral Solid Products
Coating of Primary Powder Particles Improves the Quality of Binder Jetting 3D Printed Oral Solid Products Open
Binder jetting (BJ) 3D printing is especially suitable for the fabrication of an orodispersible solid dosage form, as it is an efficient way to avoid the use of mechanical forces typical for compaction-based processes. However, one of the …
View article: Structured approach for designing drug-loaded solid products by binder jetting 3D printing
Structured approach for designing drug-loaded solid products by binder jetting 3D printing Open
Additive manufacturing allows for designing innovative properties to pharmaceutical products. Binder jetting (BJ) 3D printing is one of the key techniques within innovative manufacturing. In this study, a structured approach according to t…