Jean Paul Thiery
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View article: RELA Ablation Contributes to Progression of Hepatocellular Carcinoma with TP53<sup>R249S</sup> Mutation and is a Potential Therapeutic Target
RELA Ablation Contributes to Progression of Hepatocellular Carcinoma with TP53<sup>R249S</sup> Mutation and is a Potential Therapeutic Target Open
TP53 mutations are highly associated with hepatocellular carcinoma (HCC), a common and deadly cancer. However, few primary drivers in the progression of HCC with mutant TP53 have been identified. To uncover tumor suppressors in human HCC, …
View article: Ferroptosis-related LncRNAs in diseases
Ferroptosis-related LncRNAs in diseases Open
Ferroptosis is a form of regulated cell death (RCD) caused by the accumulation of intracellular iron and lipids and is involved in many pathological processes, including neurodegenerative and cardiovascular diseases, and cancer. Long non-c…
View article: Structural and mechanistic basis for the regulation of the chloroplast signal recognition particle by (p) <scp>ppGpp</scp>
Structural and mechanistic basis for the regulation of the chloroplast signal recognition particle by (p) <span>ppGpp</span> Open
The alarmones (p)ppGpp play a critical role in chloroplasts by acting as signalling molecules that regulate gene expression, protein synthesis and chloroplast ( cp ) development, particularly in response to stress and nutrient availability…
View article: Co-inhibition of PGF and VEGFA enhances the effectiveness of immunotherapy in bladder cancer
Co-inhibition of PGF and VEGFA enhances the effectiveness of immunotherapy in bladder cancer Open
Background: Anti-angiogenic inhibitors and immune checkpoint blockade combination therapy offers a novel approach to circumvent the challenges associated with limited responsiveness to checkpoint inhibitors in bladder cancer. However, the …
View article: Supplementary Data from The m6A reader YTHDF2 promotes bladder cancer progression by suppressing RIG-I-mediated immune response
Supplementary Data from The m6A reader YTHDF2 promotes bladder cancer progression by suppressing RIG-I-mediated immune response Open
Supplementary table ST3
View article: Supplementary Data from The m6A reader YTHDF2 promotes bladder cancer progression by suppressing RIG-I-mediated immune response
Supplementary Data from The m6A reader YTHDF2 promotes bladder cancer progression by suppressing RIG-I-mediated immune response Open
Supplementary Data clean version
View article: Data from The m6A reader YTHDF2 promotes bladder cancer progression by suppressing RIG-I-mediated immune response
Data from The m6A reader YTHDF2 promotes bladder cancer progression by suppressing RIG-I-mediated immune response Open
N6-Methyladenosine (m6A) is the most prevalent internal modification among mammalian mRNAs. Recent studies show that m6A methyltransferases, METTL3 and METTL14, play important roles in bladder carcinoma (BLCA). However, the impact of YTHDF…
View article: Supplementary Data from The m6A reader YTHDF2 promotes bladder cancer progression by suppressing RIG-I-mediated immune response
Supplementary Data from The m6A reader YTHDF2 promotes bladder cancer progression by suppressing RIG-I-mediated immune response Open
Supplementary Data clean version
View article: Supplementary Data from The m6A reader YTHDF2 promotes bladder cancer progression by suppressing RIG-I-mediated immune response
Supplementary Data from The m6A reader YTHDF2 promotes bladder cancer progression by suppressing RIG-I-mediated immune response Open
Supplementary table ST3
View article: Circulating tumour cells predict recurrences and survival in head and neck squamous cell carcinoma patients
Circulating tumour cells predict recurrences and survival in head and neck squamous cell carcinoma patients Open
Patients with head and neck squamous cell carcinoma (HNSCC) are at a high risk of developing recurrence and secondary cancers. This study evaluates the prognostic and surveillance utilities of circulating tumour cells (CTCs) in HNSCC. A to…
View article: The selective sponging of miRNAs by OIP5-AS1 regulates metabolic reprogramming of pyruvate in adenoma-carcinoma transition of human colorectal cancer
The selective sponging of miRNAs by OIP5-AS1 regulates metabolic reprogramming of pyruvate in adenoma-carcinoma transition of human colorectal cancer Open
RNA interactomes and their diversified functionalities have recently benefited from critical methodological advances leading to a paradigm shift from a conventional conception on the regulatory roles of RNA in pathogenesis. However, the dy…
View article: How studies in developmental epithelial-mesenchymal transition and mesenchymal-epithelial transition inspired new research paradigms in biomedicine
How studies in developmental epithelial-mesenchymal transition and mesenchymal-epithelial transition inspired new research paradigms in biomedicine Open
Epithelial-mesenchymal transition (EMT) and its reverse mechanism, mesenchymal-epithelial transition (MET), are evolutionarily conserved mechanisms initially identified in studies of early metazoan development. EMT may even have been estab…
View article: SHP2 inhibitors maintain TGFβ signalling through SMURF2 inhibition
SHP2 inhibitors maintain TGFβ signalling through SMURF2 inhibition Open
Despite the promising antitumor activity of SHP2 inhibitors in RAS-dependent tumours, overall responses have been limited by their narrow therapeutic window. Like with all MAPK pathway inhibitors, this is likely the result of compensatory …
View article: TGF-β, EMT, and resistance to anti-cancer treatment
TGF-β, EMT, and resistance to anti-cancer treatment Open
Transforming growth factor-β (TGF-β) signaling regulates cell-specific programs involved in embryonic development, wound-healing, and immune homeostasis. Yet, during tumor progression, these TGF-β-mediated programs are altered, leading to …
View article: 331 Functional enhancement of T cells by the co-expression of IL-7 and dominant-negative TGFβRII
331 Functional enhancement of T cells by the co-expression of IL-7 and dominant-negative TGFβRII Open
Background The effect of transforming growth factor β (TGF-β) is cell type- and context-dependent. In the tumor microenvironment, TGF-β restricts T cells' expansion, survival, and antitumor efficacy.1 2 Blocking of the TGF-β signaling enha…
View article: Intrinsic cancer cell phosphoinositide 3‐kinase δ regulates fibrosis and vascular development in cholangiocarcinoma
Intrinsic cancer cell phosphoinositide 3‐kinase δ regulates fibrosis and vascular development in cholangiocarcinoma Open
Background & Aims The class I‐ phosphatidylinositol‐3 kinases (PI3Ks) signalling is dysregulated in almost all human cancers whereas the isoform‐specific roles remain poorly investigated. We reported that the isoform δ (PI3Kδ) regulated ep…
View article: T lymphocytes expressing the switchable chimeric Fc receptor CD64 exhibit augmented persistence and antitumor activity
T lymphocytes expressing the switchable chimeric Fc receptor CD64 exhibit augmented persistence and antitumor activity Open
Chimeric antigen receptor (CAR) T cell therapy lacks persistent efficacy with "on-target, off-tumor" toxicities for treating solid tumors. Thus, an antibody-guided switchable CAR vector, the chimeric Fc receptor CD64 (CFR64), composed of a…
View article: Circulating Tumour Cells Predict Recurrences and Survival in Head and Neck Squamous Cell Carcinoma Patients
Circulating Tumour Cells Predict Recurrences and Survival in Head and Neck Squamous Cell Carcinoma Patients Open
Background Patients with head and neck squamous cell carcinoma (HNSCC) are at high risk of developing locoregional recurrence and secondary cancers. Early prediction is crucial for improving outcomes. This study evaluates the prognostic an…
View article: Supplementary Data from The m<sup>6</sup>A Reader YTHDF2 Promotes Bladder Cancer Progression by Suppressing RIG-I–Mediated Immune Response
Supplementary Data from The m<sup>6</sup>A Reader YTHDF2 Promotes Bladder Cancer Progression by Suppressing RIG-I–Mediated Immune Response Open
Supplementary Data clean version
View article: Supplementary Data from The m<sup>6</sup>A Reader YTHDF2 Promotes Bladder Cancer Progression by Suppressing RIG-I–Mediated Immune Response
Supplementary Data from The m<sup>6</sup>A Reader YTHDF2 Promotes Bladder Cancer Progression by Suppressing RIG-I–Mediated Immune Response Open
Supplementary table ST3