József Tı́már
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View article: Distant metastases of melanoma exhibit varying extent of intrapatient proteogenomic heterogeneity
Distant metastases of melanoma exhibit varying extent of intrapatient proteogenomic heterogeneity Open
Background Metastatic melanoma is a highly aggressive disease with poor survival rates despite recent therapeutic advancements with immunotherapy. The proteomic landscape of advanced melanoma remains poorly understood, especially regarding…
View article: Differential PCNA Expression Between Neoplastic and Adjacent Mucosa as a Prognostic Marker in Colorectal Adenoma-Carcinoma Progression
Differential PCNA Expression Between Neoplastic and Adjacent Mucosa as a Prognostic Marker in Colorectal Adenoma-Carcinoma Progression Open
PCNA-ED is strongly associated with malignant transformation, recurrence, and adverse prognosis in colorectal neoplasms. Its measurement may offer valuable prognostic insight and inform postoperative management strategies.
View article: Mitochondrial proteome landscape unveils key insights into melanoma severity and treatment strategies
Mitochondrial proteome landscape unveils key insights into melanoma severity and treatment strategies Open
Background Melanoma, the deadliest form of skin cancer, exhibits resistance to conventional therapies, particularly in advanced and metastatic stages. Mitochondrial pathways, including oxidative phosphorylation and mitochondrial translatio…
View article: Melanoma Proteomics Unveiled: Harmonizing Diverse Data Sets for Biomarker Discovery and Clinical Insights via MEL-PLOT
Melanoma Proteomics Unveiled: Harmonizing Diverse Data Sets for Biomarker Discovery and Clinical Insights via MEL-PLOT Open
Using several melanoma proteomics data sets we created a single analysis platform that enables the discovery, knowledge build, and validation of diagnostic, predictive, and prognostic biomarkers at the protein level. Quantitative mass-spec…
View article: Clinical Applications of the Molecular Landscape of Melanoma: Integration of Research into Diagnostic and Therapeutic Strategies
Clinical Applications of the Molecular Landscape of Melanoma: Integration of Research into Diagnostic and Therapeutic Strategies Open
The molecular landscape of cutaneous melanoma is complex and heterogeneous, and a deeper understanding of the genesis and progression of the tumor driven by genetic alterations is essential for the development of effective diagnostic and t…
View article: Neoadjuvant leukocyte interleukin injection immunotherapy improves overall survival in low-risk locally advanced head and neck squamous cell carcinoma –the IT-MATTERS study
Neoadjuvant leukocyte interleukin injection immunotherapy improves overall survival in low-risk locally advanced head and neck squamous cell carcinoma –the IT-MATTERS study Open
The randomized controlled pivotal phase 3 study evaluated efficacy and safety of neoadjuvant complex biologic, Leukocyte Interleukin Injection (LI), administered for 3 consecutive weeks pre-surgery, in treatment naïve resectable locally ad…
View article: Combination of farnesyl-transferase inhibition with KRAS G12D targeting breaks down therapeutic resistance in pancreatic cancer
Combination of farnesyl-transferase inhibition with KRAS G12D targeting breaks down therapeutic resistance in pancreatic cancer Open
Pancreatic adenocarcinoma is one of the deadliest forms of cancer with no effective therapeutic options. A KRAS mutation can be found in up to 90% of all pancreatic tumors, making it a promising therapeutic target. The introduction of new …
View article: Microsatellite instability and mismatch repair protein deficiency: equal predictive markers?
Microsatellite instability and mismatch repair protein deficiency: equal predictive markers? Open
Current clinical guidelines recommend mismatch repair (MMR) protein immunohistochemistry (IHC) or molecular microsatellite instability (MSI) tests as predictive markers of immunotherapies. Most of the pathological guidelines consider MMR p…
View article: Gluing GAP to RAS Mutants: A New Approach to an Old Problem in Cancer Drug Development
Gluing GAP to RAS Mutants: A New Approach to an Old Problem in Cancer Drug Development Open
Mutated genes may lead to cancer development in numerous tissues. While more than 600 cancer-causing genes are known today, some of the most widespread mutations are connected to the RAS gene; RAS mutations are found in approximately 25% o…
View article: Editorial: Pathology and Oncology Research: addressing publication ethics issues
Editorial: Pathology and Oncology Research: addressing publication ethics issues Open
EDITORIAL Pathol. Oncol. Res., 14 February 2024 https://doi.org/10.3389/pore.2024.1611691
View article: Comparison of standard mismatch repair deficiency and microsatellite instability tests in a large cancer series
Comparison of standard mismatch repair deficiency and microsatellite instability tests in a large cancer series Open
Background The tumor-agnostic indication of immune checkpoint inhibitors to treat cancers with mismatch repair deficiency (dMMR)/microsatellite instability (MSI) increased the demand for such tests beyond Lynch syndrome. International guid…
View article: KRASG12C mutant lung adenocarcinoma: unique biology, novel therapies and new challenges
KRASG12C mutant lung adenocarcinoma: unique biology, novel therapies and new challenges Open
KRAS mutant lung cancer is the most prevalent molecular subclass of adenocarcinoma (LUAD), which is a heterogenous group depending on the mutation-type which affects not only the function of the oncogene but affects the biological behavior…
View article: Gluing GAP to RAS Mutants: A New Approach to an Old Problem in Cancer Drug Development
Gluing GAP to RAS Mutants: A New Approach to an Old Problem in Cancer Drug Development Open
Mutated genes may lead to cancer development in numerous tissues. While more than 600 cancer-causing genes are known today, some of the most widespread mutations are connected to the RAS gene: RAS mutations are found in approximately 25% o…
View article: The Driverless Triple-Wild-Type (BRAF, RAS, KIT) Cutaneous Melanoma: Whole Genome Sequencing Discoveries
The Driverless Triple-Wild-Type (BRAF, RAS, KIT) Cutaneous Melanoma: Whole Genome Sequencing Discoveries Open
The genetic makeup of the triple-wild-type melanoma (BRAF, NRAS and NF1) has been known for some time, but those studies grouped together rare histopathological versions with common ones, as well as mucosal and even uveal ones. Here we use…
View article: Metastatic Progression of Human Melanoma
Metastatic Progression of Human Melanoma Open
This Topical Collection, comprising 13 papers (10 original articles and 3 reviews), addresses various aspects of the field of melanoma progression: genomic and proteomic approaches, experimental studies, the questions of sentinel lymph nod…
View article: Newly identified form of phenotypic plasticity of cancer: immunogenic mimicry
Newly identified form of phenotypic plasticity of cancer: immunogenic mimicry Open
Cancer plasticity is now a recognized new hallmark of cancer which is due to disturbances of cell differentiation programs. It is manifested not only in various forms like the best-known epithelial-mesenchymal transition (EMT) but also in …
View article: Clinical sequencing identifies potential actionable alterations in a high rate of urachal and primary bladder adenocarcinomas
Clinical sequencing identifies potential actionable alterations in a high rate of urachal and primary bladder adenocarcinomas Open
Objective Administration of targeted therapies provides a promising treatment strategy for urachal adenocarcinoma (UrC) or primary bladder adenocarcinoma (PBAC); however, the selection of appropriate drugs remains difficult. Here, we aimed…
View article: Proteogenomic Characterization Reveals Therapeutic Opportunities Related to Mitochondrial Function in Melanoma
Proteogenomic Characterization Reveals Therapeutic Opportunities Related to Mitochondrial Function in Melanoma Open
Summary The dynamics of more than 1900 mitochondrial proteins was explored through quantitative proteomics in 151 melanoma-related tissue samples of both surgical and autopsy origin. Dysregulation of mitochondrial pathways in primary tumor…
View article: On-Target Side Effects of Targeted Therapeutics of Cancer
On-Target Side Effects of Targeted Therapeutics of Cancer Open
The concept of precision medicine is based on the identification of hallmarks of cancer to exploit them as drug targets. The basic idea was that in this way the therapeutic modalities will be more effective and the side effects will be les…
View article: Clinical sequencing identifies potential actionable alterations in a high rate of urachal and primary bladder adenocarcinomas
Clinical sequencing identifies potential actionable alterations in a high rate of urachal and primary bladder adenocarcinomas Open
Administration of targeted therapies provides a promising treatment strategy for rare cancers such as urachal adenocarcinoma (UrC) or primary bladder adenocarcinoma (PBAC), however, the selection of appropriate drugs remains difficult. The…
View article: Molecular Pathology of Skin Melanoma: Epidemiology, Differential Diagnostics, Prognosis and Therapy Prediction
Molecular Pathology of Skin Melanoma: Epidemiology, Differential Diagnostics, Prognosis and Therapy Prediction Open
Similar to other malignancies, TCGA network efforts identified the detailed genomic picture of skin melanoma, laying down the basis of molecular classification. On the other hand, genome-wide association studies discovered the genetic back…
View article: Identification of a Tumor Cell Associated Type I IFN Resistance Gene Expression Signature of Human Melanoma, the Components of Which Have a Predictive Potential for Immunotherapy
Identification of a Tumor Cell Associated Type I IFN Resistance Gene Expression Signature of Human Melanoma, the Components of Which Have a Predictive Potential for Immunotherapy Open
We developed a human melanoma model using the HT168-M1 cell line to induce IFN-α2 resistance in vitro (HT168-M1res), which was proven to be maintained in vivo in SCID mice. Comparing the mRNA profile of in vitro cultured HT168-M1res cells …
View article: Organ Specific Copy Number Variations in Visceral Metastases of Human Melanoma
Organ Specific Copy Number Variations in Visceral Metastases of Human Melanoma Open
Malignant melanoma is one of the most aggressive skin cancers with high potential of visceral dissemination. Since the information about melanoma genomics is mainly based on primary tumors and lymphatic or skin metastases, an autopsy-based…
View article: The human melanoma proteome atlas—Defining the molecular pathology
The human melanoma proteome atlas—Defining the molecular pathology Open
The MM500 study is an initiative to map the protein levels in malignant melanoma tumor samples, focused on in‐depth histopathology coupled to proteome characterization. The protein levels and localization were determined for a broad spectr…
View article: The Human Melanoma Proteome Atlas—Complementing the melanoma transcriptome
The Human Melanoma Proteome Atlas—Complementing the melanoma transcriptome Open
The MM500 meta‐study aims to establish a knowledge basis of the tumor proteome to serve as a complement to genome and transcriptome studies. Somatic mutations and their effect on the transcriptome have been extensively characterized in mel…
View article: A subset of lung cancer cases shows robust signs of homologous recombination deficiency associated genomic mutational signatures
A subset of lung cancer cases shows robust signs of homologous recombination deficiency associated genomic mutational signatures Open
PARP inhibitors are approved for the treatment of solid tumor types that frequently harbor alterations in the key homologous recombination (HR) genes, BRCA1/2 . Other tumor types, such as lung cancer, may also be HR deficient, but the freq…
View article: Hypoxia Signaling in Cancer: From Basics to Clinical Practice
Hypoxia Signaling in Cancer: From Basics to Clinical Practice Open
Cancer hypoxia, recognized as one of the most important hallmarks of cancer, affects gene expression, metabolism and ultimately tumor biology-related processes. Major causes of cancer hypoxia are deficient or inappropriate vascularization …
View article: Proteogenomics Reveals how Metastatic Melanoma Modulates the Immune System to Allow Immune Evasion
Proteogenomics Reveals how Metastatic Melanoma Modulates the Immune System to Allow Immune Evasion Open
Summary Malignant melanoma (MM) develops from the melanocytes and in its advanced stage is the most aggressive type of skin cancer. Here we report a comprehensive analysis on a prospective cohort study, including non-tumor, primary and met…