Jörg Timm
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View article: Expression of CD38 on resting peripheral iNKT cells defines an immature subpopulation with distinct functionality in humans
Expression of CD38 on resting peripheral iNKT cells defines an immature subpopulation with distinct functionality in humans Open
Human invariant natural killer T cells (iNKT) play an important role in an orchestrated immune response; however, the heterogeneity of iNKT subsets is not yet fully understood. Here, we uncovered CD38 as a marker of iNKT differentiation, d…
View article: HIV-1 virologic failure in the RESINA cohort: lessons from two decades of real-world data
HIV-1 virologic failure in the RESINA cohort: lessons from two decades of real-world data Open
Purpose To quantify virologic failure (VF), identify predictors, characterize resistance patterns at failure, and evaluate time to resuppression in the RESINA cohort. Methods ART-naïve adults initiating ART in 2001–2024 were followed. VF w…
View article: Chronic Hepatitis B Virus Infection Acquired Under Cytostatic Treatment in Childhood — Clinical, Virological and Immunological Long‐Term Follow‐Up
Chronic Hepatitis B Virus Infection Acquired Under Cytostatic Treatment in Childhood — Clinical, Virological and Immunological Long‐Term Follow‐Up Open
Oncology patients receiving cytostatic therapy used to be at high risk of HBV infection when HBV screening measures were less reliable. Infections acquired under these conditions often persist, like those acquired perinatally or during ear…
View article: Whole-genome nanopore sequencing and automatic downstream analysis of respiratory syncytial virus using RSVTyper
Whole-genome nanopore sequencing and automatic downstream analysis of respiratory syncytial virus using RSVTyper Open
Respiratory syncytial virus (RSV) is a globally circulating virus, causing severe respiratory infections in infants and the elderly. Two RSV vaccines were recently approved, and passive immunization is now recommended in several countries …
View article: Whole-Genome Sequencing of Hepatitis B Virus Genotypes E and A in Zambia Reveals Limited Viral Diversity in HIV Coinfection
Whole-Genome Sequencing of Hepatitis B Virus Genotypes E and A in Zambia Reveals Limited Viral Diversity in HIV Coinfection Open
Background The molecular characteristics of hepatitis B virus (HBV) in Africa, including the impact of HIV coinfection, are poorly understood. Methods We performed whole-genome sequencing (WGS) on biospecimens collected before antiviral th…
View article: A healthcare-associated outbreak of hepatitis C virus infections attributable to tampering injectable anaesthetic opioids, South Germany, 2017–2018
A healthcare-associated outbreak of hepatitis C virus infections attributable to tampering injectable anaesthetic opioids, South Germany, 2017–2018 Open
Introduction In October 2018, an outbreak of hepatitis C virus (HCV) in southern Germany was communicated to the Robert Koch Institute (RKI). Healthcare-associated transmission during invasive procedures involving a specific anaesthetist a…
View article: Prevalence of Resistance‐Associated Mutations in RSV F Protein Against Monoclonal Antibodies Prior to Widespread Implementation: Findings From a Prospective German Pediatric Cohort
Prevalence of Resistance‐Associated Mutations in RSV F Protein Against Monoclonal Antibodies Prior to Widespread Implementation: Findings From a Prospective German Pediatric Cohort Open
Background The emergence of resistance‐associated substitutions in RSV against novel monoclonal antibodies is a concern given widespread prophylactic use. Aim To assess the prevalence of resistance‐associated substitutions in the RSV F pro…
View article: Genomics-enhanced contact tracing enabled the characterization of SARS-CoV-2 transmission chains and their associated infection contexts in the general population during community transmission
Genomics-enhanced contact tracing enabled the characterization of SARS-CoV-2 transmission chains and their associated infection contexts in the general population during community transmission Open
Understanding how pathogens spread in human populations is key to effective infection prevention, but for most pathogens in community transmission, population transmission chains and their associated infection contexts remain elusive. From…
View article: Highly replicating hepatitis C virus variants emerge in immunosuppressed patients causing severe disease
Highly replicating hepatitis C virus variants emerge in immunosuppressed patients causing severe disease Open
Hepatitis C virus (HCV) exists as a heterogenous quasispecies, but the phenotypic consequences of viral variability are widely unexplored. Here we identified a replication enhancing domain (ReED) in nonstructural protein 5A conferring high…
View article: Comparison of immune responses to SARS-CoV-2 spike following Omicron infection or Omicron BA.4/5 vaccination in kidney transplant recipients
Comparison of immune responses to SARS-CoV-2 spike following Omicron infection or Omicron BA.4/5 vaccination in kidney transplant recipients Open
Background The emergence of novel SARS-CoV-2 variants challenges immunity, particularly among immunocompromised kidney transplant recipients (KTRs). To address this, vaccines have been adjusted to circulating variants. Despite intensive va…
View article: Progress and challenges in the elimination of hepatitis C among people who inject drugs in Germany: results of a pilot study for a national monitoring system, 10 years after the first data collection
Progress and challenges in the elimination of hepatitis C among people who inject drugs in Germany: results of a pilot study for a national monitoring system, 10 years after the first data collection Open
Background People who inject drugs (PWID) are at high risk of blood-borne infections, and injection drug use contributes significantly to hepatitis C virus (HCV) transmission. The WHO has therefore set targets of reducing HCV incidence and…
View article: HBV shows different levels of adaptation to HLA class I-associated selection pressure correlating with markers of replication
HBV shows different levels of adaptation to HLA class I-associated selection pressure correlating with markers of replication Open
The immune response mediated by CD8 T cells plays a critical role in controlling HBV infection and shows promise for therapeutic strategies aimed at achieving a functional cure. This study demonstrates that mutational escape within CD8 T-c…
View article: Trajectories and predictive significance of inflammatory parameters for clinical outcome in COVID–19 patients treated with tocilizumab
Trajectories and predictive significance of inflammatory parameters for clinical outcome in COVID–19 patients treated with tocilizumab Open
Purpose The IL-6 receptor inhibitor tocilizumab reduces mortality and morbidity in severe cases of COVID-19 through its effects on hyperinflammation and was approved as adjuvant therapy. Since tocilizumab changes the levels of inflammatory…
View article: Knowledge of, and attitude towards, the treatment of hepatitis C in people who inject drugs
Knowledge of, and attitude towards, the treatment of hepatitis C in people who inject drugs Open
Background Direct acting antivirals (DAAs) as a curative treatment of hepatitis C have been available for several years and have replaced interferon-containing therapies. However, treatment rates of people who inject drugs (PWID) are decli…
View article: Trajectories and predictive significance of inflammatory parameters for clinical outcome in COVID-19 patients treated with tocilizumab
Trajectories and predictive significance of inflammatory parameters for clinical outcome in COVID-19 patients treated with tocilizumab Open
Purpose: The IL-6 receptor inhibitor tocilizumab reduces mortality and morbidity in severe cases of COVID-19 through its effects on hyperinflammation and was approved as adjuvant therapy. Since tocilizumab changes the levels of inflammator…
View article: Real-world performance of the NeuMoDx™ HCV Quant Test for quantification of hepatitis C virus (HCV)-RNA
Real-world performance of the NeuMoDx™ HCV Quant Test for quantification of hepatitis C virus (HCV)-RNA Open
Quantification of hepatitis C virus (HCV)-RNA in serum or plasma samples is an essential parameter in HCV diagnostics. Here, the NeuMoDx™Molecular System (Qiagen) was tested for the most common HCV genotypes and compared to the cobas c6800…
View article: Characterization of CD34+ Cells from Patients with Acute Myeloid Leukemia (AML) and Myelodysplastic Syndromes (MDS) Using a t-Distributed Stochastic Neighbor Embedding (t-SNE) Protocol
Characterization of CD34+ Cells from Patients with Acute Myeloid Leukemia (AML) and Myelodysplastic Syndromes (MDS) Using a t-Distributed Stochastic Neighbor Embedding (t-SNE) Protocol Open
Using multi-color flow cytometry analysis, we studied the immunophenotypical differences between leukemic cells from patients with AML/MDS and hematopoietic stem and progenitor cells (HSPCs) from patients in complete remission (CR) followi…
View article: Characterization of CD34+ Cells from Patients with Acute Myeloid Leukemia (AML) and Myelodysplastic Syndromes (MDS) Using a t-distributed Stochastic Neighbor Embedding (T-SNE) Protocol
Characterization of CD34+ Cells from Patients with Acute Myeloid Leukemia (AML) and Myelodysplastic Syndromes (MDS) Using a t-distributed Stochastic Neighbor Embedding (T-SNE) Protocol Open
Using multi-color flow cytometry analysis, we studied the immunophenotypical differences between leukemic blasts/LSCs from patients with AML/MDS and hematopoietic stem and progenitor cells (HSPCs) from patients in complete remission (CR) f…
View article: Infectious Complications in Patients with Myelodysplastic Syndromes: A Report from the Düsseldorf MDS Registry
Infectious Complications in Patients with Myelodysplastic Syndromes: A Report from the Düsseldorf MDS Registry Open
Despite notable advancements in infection prevention and treatment, individuals with hematologic malignancies still face the persistent threat of frequent and life-threatening complications. Those undergoing chemotherapy or other disease-m…
View article: Dynamics of Virological and Clinical Response Parameters of Bulevirtide Treatment for Hepatitis D: Real-World Data
Dynamics of Virological and Clinical Response Parameters of Bulevirtide Treatment for Hepatitis D: Real-World Data Open
Bulevirtide is a safe treatment option for HDV, leading to a fast hepatological response. Of note, decrease in transaminases precedes virological response. Patients with high viral load and ALT levels respond slower, but nonresponders (as …
View article: Eligibility and efficacy of a <scp>CPC‐</scp> and <scp>CHX</scp>‐based antiviral mouthwash for the elimination of <scp>SARS‐CoV</scp>‐2 from the saliva: A randomized, double‐blind, controlled clinical trial
Eligibility and efficacy of a <span>CPC‐</span> and <span>CHX</span>‐based antiviral mouthwash for the elimination of <span>SARS‐CoV</span>‐2 from the saliva: A randomized, double‐blind, controlled clinical trial Open
Aim This study aimed at investigating the efficacy of a 0.05% cetylpyridinium chloride–0.05% chlorhexidine (CPC–CHX) mouthwash in reducing viral load in the saliva as compared with sterile water. Materials and Methods Forty SARS‐CoV‐2 posi…
View article: Stability and Inactivation of Monkeypox Virus on Inanimate Surfaces
Stability and Inactivation of Monkeypox Virus on Inanimate Surfaces Open
The spread of nonzoonotic monkeypox virus (MPXV) infections necessitates the reevaluation of hygiene measures. To date, only limited data are available on MPXV surface stability. Here, we evaluate the stability of infectious MPXV on stainl…
View article: Sequence diversity of hepatitis D virus in Mongolia
Sequence diversity of hepatitis D virus in Mongolia Open
Introduction The Hepatitis Delta Virus (HDV) is a defective, single-stranded RNA virusoid encoding for a single protein, the Hepatitis Delta Antigen (HDAg), which requires the hepatitis B virus (HBV) envelope protein (HBsAg) for its transm…