J. Villandre
YOU?
Author Swipe
View article: NSP7 Molecular Degrader Attenuates Coronaviral Infection Through the β‐TrCP1/FBXO5 Axis
NSP7 Molecular Degrader Attenuates Coronaviral Infection Through the β‐TrCP1/FBXO5 Axis Open
NSP7 (Non‐Structural Protein 7) of SARS‐CoV‐2 is a crucial component for viral replication and transcription. In this study, it is revealed that the host E3 ubiquitin ligase FBXO5 suppresses viral replication by mediating NSP7 lysine‐48‐li…
View article: The paradox of the safer cigarette: understanding the pulmonary effects of electronic cigarettes
The paradox of the safer cigarette: understanding the pulmonary effects of electronic cigarettes Open
Electronic cigarette (e-cigarette) use continues to rise globally. E-cigarettes have been presented as safer alternatives to combustion cigarettes that can mitigate the harm associated with tobacco products; however, the degree to which e-…
View article: Fibronectin-EDA accumulates via reduced ubiquitination downstream of Toll-like receptor 9 activation in SSc-ILD fibroblasts
Fibronectin-EDA accumulates via reduced ubiquitination downstream of Toll-like receptor 9 activation in SSc-ILD fibroblasts Open
Accumulation of excessive extracellular matrix (ECM) components from lung fibroblasts is a feature of systemic sclerosis-associated interstitial lung disease (SSc-ILD), and there is increasing evidence that innate immune signaling pathways…
View article: A Repurposed Drug Screen for Compounds Regulating Aquaporin 5 Stability in Lung Epithelial Cells
A Repurposed Drug Screen for Compounds Regulating Aquaporin 5 Stability in Lung Epithelial Cells Open
Aquaporin 5 (AQP5) is expressed in several cell types in the lung and regulates water transport, which contributes to barrier function during injury and the composition of glandular secretions. Reduced AQP5 expression is associated with ba…
View article: Plasma 1,3-β-d-glucan levels predict adverse clinical outcomes in critical illness
Plasma 1,3-β-d-glucan levels predict adverse clinical outcomes in critical illness Open
BACKGROUNDThe fungal cell wall constituent 1,3-β-d-glucan (BDG) is a pathogen-associated molecular pattern that can stimulate innate immunity. We hypothesized that BDG from colonizing fungi in critically ill patients may translocate into t…
View article: Aberrant Toll-Like Receptor 9 Expression and Signaling Increases Fibronectin Secretion in Scleroderma Lung Fibroblasts
Aberrant Toll-Like Receptor 9 Expression and Signaling Increases Fibronectin Secretion in Scleroderma Lung Fibroblasts Open
View article: Study of Immunoglobulin Bound Oral Microbiota in People Living with HIV
Study of Immunoglobulin Bound Oral Microbiota in People Living with HIV Open
View article: Toll-like Receptor 8 Stability Is Regulated by Ring Finger 216 in Response to Circulating MicroRNAs
Toll-like Receptor 8 Stability Is Regulated by Ring Finger 216 in Response to Circulating MicroRNAs Open
TLR8 (Toll-like receptor 8) is an intracellular pattern recognition receptor that senses RNA in endosomes to initiate innate immune signaling through NF-κB, and mechanisms regulating TLR8 protein abundance are not completely understood. Pr…