Alvin Lee
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View article: EPCO-16. CHROMATIN REMODELING WITH COMBINED FACT AND BET INHIBITION DISRUPTS ONCOGENIC TRANSCRIPTION IN DIFFUSE MIDLINE GLIOMA
EPCO-16. CHROMATIN REMODELING WITH COMBINED FACT AND BET INHIBITION DISRUPTS ONCOGENIC TRANSCRIPTION IN DIFFUSE MIDLINE GLIOMA Open
Aberrant epigenetic regulation is a hallmark of Diffuse Midline Glioma (DMG), an incurable pediatric brain tumor. The H3K27M driver histone mutation leads to transcriptional dysregulation, indicating that targeting the epigenome and transc…
View article: Aberrant recursive splicing in a human disease locus
Aberrant recursive splicing in a human disease locus Open
Recursive splice sites are rare motifs postulated to facilitate splicing across massive introns and shape isoform diversity, especially for long, brain-expressed genes. The necessity of this unique mechanism remains unsubstantiated, as doe…
View article: A pilot project harnessing surveillance systems to support clinicians providing clinical care for people diagnosed with hepatitis C in Victoria, Australia, September 2021 to 31 March 2022
A pilot project harnessing surveillance systems to support clinicians providing clinical care for people diagnosed with hepatitis C in Victoria, Australia, September 2021 to 31 March 2022 Open
Background Active follow-up of chronic hepatitis C notifications to promote linkage to care is a promising strategy to support elimination. Aim This pilot study in Victoria, Australia, explored if the Department of Health could follow-up o…
View article: DIPG-16. THE BIG AND SMALL OF PROTEIN POST-TRANSLATIONAL MODIFICATIONS: TARGETING SUMOYLATION AND CITRULLINATION IN DIFFUSE MIDLINE GLIOMA
DIPG-16. THE BIG AND SMALL OF PROTEIN POST-TRANSLATIONAL MODIFICATIONS: TARGETING SUMOYLATION AND CITRULLINATION IN DIFFUSE MIDLINE GLIOMA Open
BACKGROUND Protein post-translational modifications (PTMs) alter the properties of protein through proteolytic cleavage, or the addition of modifying groups to one or more amino acids. Histones are major targets of PTMs, including through …
View article: Chromatin remodeling with combined FACT and BET inhibition disrupts oncogenic transcription in Diffuse Midline Glioma
Chromatin remodeling with combined FACT and BET inhibition disrupts oncogenic transcription in Diffuse Midline Glioma Open
Aberrant epigenetic regulation is a hallmark of Diffuse Midline Glioma (DMG), an incurable pediatric brain tumor. The H3K27M driver histone mutation leads to transcriptional dysregulation, indicating that targeting the epigenome and transc…
View article: A Comprehensive Review and Investigation of Business Models
A Comprehensive Review and Investigation of Business Models Open
The formulation and execution of a business model significantly influence the achievement and durability of a company. The business model serves as a strategic framework encompassing components such as value proposition, revenue streams, m…
View article: Impact of SARS-CoV-2 vaccines and recent chemotherapy on COVID-19 morbidity and mortality in patients with soft tissue sarcoma: an analysis from the OnCovid registry
Impact of SARS-CoV-2 vaccines and recent chemotherapy on COVID-19 morbidity and mortality in patients with soft tissue sarcoma: an analysis from the OnCovid registry Open
Background: To date, limited evidence exists on the impact of COVID-19 in patients with soft tissue sarcoma (STS), nor about the impact of SARS-CoV-2 vaccines and recent chemotherapy on COVID-19 morbidity and mortality in this specific pop…
View article: Previous immune checkpoint inhibitor therapy is associated with decreased COVID-19-related hospitalizations and complications in patients with cancer: Results of a propensity-matched analysis of the OnCovid registry
Previous immune checkpoint inhibitor therapy is associated with decreased COVID-19-related hospitalizations and complications in patients with cancer: Results of a propensity-matched analysis of the OnCovid registry Open
In this propensity-score matched analysis, previous ICI therapy did not worsen and potentially improved COVID-19 outcomes in patients with cancer.
View article: Intra‐ and interhost genomic diversity of monkeypox virus
Intra‐ and interhost genomic diversity of monkeypox virus Open
The impact and frequency of infectious disease outbreaks demonstrate the need for timely genomic surveillance to inform public health responses. In the largest known outbreak of mpox, genomic surveillance efforts have primarily focused on …
View article: Barotolerance of Acid-adapted and Cold-adapted Bacterial Isolates of E. coli O157:H7, Salmonella spp., and L. monocytogenes in an Acidic Buffer Model
Barotolerance of Acid-adapted and Cold-adapted Bacterial Isolates of E. coli O157:H7, Salmonella spp., and L. monocytogenes in an Acidic Buffer Model Open
The fruit and vegetable juice industry has shown a growing trend in minimally processed juices. A frequent technology used in the production of functional juices is cold pressure, which refers to the application of high pressure processing…
View article: Supplementary Data from Clinical Portrait of the SARS-CoV-2 Epidemic in European Patients with Cancer
Supplementary Data from Clinical Portrait of the SARS-CoV-2 Epidemic in European Patients with Cancer Open
Supplementary Tables and Figures
View article: Supplementary Data from Clinical Portrait of the SARS-CoV-2 Epidemic in European Patients with Cancer
Supplementary Data from Clinical Portrait of the SARS-CoV-2 Epidemic in European Patients with Cancer Open
Supplementary Tables and Figures
View article: Data from Clinical Portrait of the SARS-CoV-2 Epidemic in European Patients with Cancer
Data from Clinical Portrait of the SARS-CoV-2 Epidemic in European Patients with Cancer Open
The SARS-CoV-2 pandemic significantly affected oncology practice across the globe. There is uncertainty as to the contribution of patients' demographics and oncologic features to severity and mortality from COVID-19 and little guidance as …
View article: Data from Clinical Portrait of the SARS-CoV-2 Epidemic in European Patients with Cancer
Data from Clinical Portrait of the SARS-CoV-2 Epidemic in European Patients with Cancer Open
The SARS-CoV-2 pandemic significantly affected oncology practice across the globe. There is uncertainty as to the contribution of patients' demographics and oncologic features to severity and mortality from COVID-19 and little guidance as …
View article: Supplementary Figure Legends 1-6 from Chromosomal Instability Confers Intrinsic Multidrug Resistance
Supplementary Figure Legends 1-6 from Chromosomal Instability Confers Intrinsic Multidrug Resistance Open
Supplementary Figure Legends 1-6 from Chromosomal Instability Confers Intrinsic Multidrug Resistance
View article: Supplementary Table 2 from Chromosomal Instability Confers Intrinsic Multidrug Resistance
Supplementary Table 2 from Chromosomal Instability Confers Intrinsic Multidrug Resistance Open
Supplementary Table 2 from Chromosomal Instability Confers Intrinsic Multidrug Resistance
View article: Supplementary Figures 4-6 from Chromosomal Instability Confers Intrinsic Multidrug Resistance
Supplementary Figures 4-6 from Chromosomal Instability Confers Intrinsic Multidrug Resistance Open
Supplementary Figures 4-6 from Chromosomal Instability Confers Intrinsic Multidrug Resistance
View article: Supplementary Data Analysis from Chromosomal Instability Confers Intrinsic Multidrug Resistance
Supplementary Data Analysis from Chromosomal Instability Confers Intrinsic Multidrug Resistance Open
Supplementary Data Analysis from Chromosomal Instability Confers Intrinsic Multidrug Resistance
View article: Supplementary Table 2 from Chromosomal Instability Confers Intrinsic Multidrug Resistance
Supplementary Table 2 from Chromosomal Instability Confers Intrinsic Multidrug Resistance Open
Supplementary Table 2 from Chromosomal Instability Confers Intrinsic Multidrug Resistance
View article: Data from Chromosomal Instability Confers Intrinsic Multidrug Resistance
Data from Chromosomal Instability Confers Intrinsic Multidrug Resistance Open
Aneuploidy is associated with poor prognosis in solid tumors. Spontaneous chromosome missegregation events in aneuploid cells promote chromosomal instability (CIN) that may contribute to the acquisition of multidrug resistance in vitro and…
View article: Supplementary Figures 1-3 from Chromosomal Instability Confers Intrinsic Multidrug Resistance
Supplementary Figures 1-3 from Chromosomal Instability Confers Intrinsic Multidrug Resistance Open
Supplementary Figures 1-3 from Chromosomal Instability Confers Intrinsic Multidrug Resistance
View article: Supplementary Figures 1-3 from Chromosomal Instability Confers Intrinsic Multidrug Resistance
Supplementary Figures 1-3 from Chromosomal Instability Confers Intrinsic Multidrug Resistance Open
Supplementary Figures 1-3 from Chromosomal Instability Confers Intrinsic Multidrug Resistance
View article: Supplementary Figure Legends 1-6 from Chromosomal Instability Confers Intrinsic Multidrug Resistance
Supplementary Figure Legends 1-6 from Chromosomal Instability Confers Intrinsic Multidrug Resistance Open
Supplementary Figure Legends 1-6 from Chromosomal Instability Confers Intrinsic Multidrug Resistance
View article: Data from Chromosomal Instability Confers Intrinsic Multidrug Resistance
Data from Chromosomal Instability Confers Intrinsic Multidrug Resistance Open
Aneuploidy is associated with poor prognosis in solid tumors. Spontaneous chromosome missegregation events in aneuploid cells promote chromosomal instability (CIN) that may contribute to the acquisition of multidrug resistance in vitro and…