S. Senkin
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View article: Genome-scale multi-organ analysis of mutagenic effects of ethanol and acetaldehyde in Sprague Dawley rats
Genome-scale multi-organ analysis of mutagenic effects of ethanol and acetaldehyde in Sprague Dawley rats Open
Alcohol consumption is a major cancer risk factor, particularly for head and neck cancers, including the oral cavity. Acetaldehyde, the primary genotoxic metabolite of ethanol, may play key roles in oral carcinogenesis, though the mechanis…
View article: Geographic and age variations in mutational processes in colorectal cancer
Geographic and age variations in mutational processes in colorectal cancer Open
Incidence rates of colorectal cancer vary geographically and have changed over time 1 . Notably, in the past two decades, the incidence of early-onset colorectal cancer, which affects individuals below 50 years of age, has doubled in many …
View article: Geographic and age-related variations in mutational processes in colorectal cancer
Geographic and age-related variations in mutational processes in colorectal cancer Open
Colorectal cancer incidence rates vary geographically and have changed over time. Notably, in the past two decades, the incidence of early-onset colorectal cancer, affecting individuals under the age of 50 years, has doubled in many countr…
View article: Human cancer genomes harbor the mutational signature of tobacco-specific nitrosamines NNN and NNK
Human cancer genomes harbor the mutational signature of tobacco-specific nitrosamines NNN and NNK Open
Tobacco usage is linked to multiple cancer types and accounts for a quarter of all cancer-related deaths. Tobacco smoke contains various carcinogenic compounds, including polycyclic aromatic hydrocarbons (PAH), though the mutagenic potenti…
View article: The Complexity of Tobacco Smoke-Induced Mutagenesis in Head and Neck Cancer
The Complexity of Tobacco Smoke-Induced Mutagenesis in Head and Neck Cancer Open
Tobacco smoke, alone or combined with alcohol, is the predominant cause of head and neck cancer (HNC). Here, we further explore how tobacco exposure contributes to cancer development by mutational signature analysis of 265 whole-genome seq…
View article: WCN24-1870 CHRONIC RENAL LESIONS IN PATIENTS WITH RENAL CELL CARCINOMA ARE ASSOCIATED WITH ARISTOLOCHIC ACID EXPOSURE AND FASTER ACCUMULATION OF DNA DAMAGE
WCN24-1870 CHRONIC RENAL LESIONS IN PATIENTS WITH RENAL CELL CARCINOMA ARE ASSOCIATED WITH ARISTOLOCHIC ACID EXPOSURE AND FASTER ACCUMULATION OF DNA DAMAGE Open
We previously reported the significant presence of moderate and severe chronic renal lesions (CRL) in Romania and Serbia (OR=2.96; p<0.05) by morphological evaluation of 1012 nontumoral (NT) tissues of RCC patients by that a possible link …
View article: Disease aetiology and progression shape the inter-patient multi-omics profile of clear cell renal carcinoma
Disease aetiology and progression shape the inter-patient multi-omics profile of clear cell renal carcinoma Open
Endogenous and exogenous processes are associated with distinctive molecular marks in somatic tissues, including human tumours. Here, we used integrative multi-omics analyses to infer sources of inter-patient somatic variation within clear…
View article: Molecular landscapes of oral cancers of unknown etiology
Molecular landscapes of oral cancers of unknown etiology Open
The incidence of the mobile tongue cancer in young patients has been rising. This oral cancer (OC) type has no identified risk factors (NIRF), no established molecular markers and is not yet recognized as a distinct clinical entity. To und…
View article: Assigning mutational signatures to individual samples and individual somatic mutations with SigProfilerAssignment
Assigning mutational signatures to individual samples and individual somatic mutations with SigProfilerAssignment Open
Motivation Analysis of mutational signatures is a powerful approach for understanding the mutagenic processes that have shaped the evolution of a cancer genome. To evaluate the mutational signatures operative in a cancer genome, one first …
View article: Variability of mutational signatures is a footprint of carcinogens
Variability of mutational signatures is a footprint of carcinogens Open
Understanding the genomic impact of carcinogens is fundamental to cancer biology and prevention. However, recent coordinated efforts to detect such fingerprints have been largely unsuccessful, challenging the paradigm that carcinogens indu…
View article: Assigning mutational signatures to individual samples and individual somatic mutations with SigProfilerAssignment
Assigning mutational signatures to individual samples and individual somatic mutations with SigProfilerAssignment Open
Analysis of mutational signatures is a powerful approach for understanding the mutagenic processes that have shaped the evolution of a cancer genome. Here we present SigProfilerAssignment, a desktop and an online computational framework fo…
View article: Geographic variation of mutagenic exposures in kidney cancer genomes
Geographic variation of mutagenic exposures in kidney cancer genomes Open
International differences in the incidence of many cancer types indicate the existence of carcinogen exposures that have not been identified by conventional epidemiology yet potentially make a substantial contribution to cancer burden 1 . …
View article: Review of: "ASPICov: An automated pipeline for identification of SARS-Cov2 nucleotidic variants"
Review of: "ASPICov: An automated pipeline for identification of SARS-Cov2 nucleotidic variants" Open
The 'ASPICov: An automated pipeline for identification of SARS-Cov2 nucleotidic variants' paper represents a pipeline to detect and identify SARS-Cov2 mutations by analyzing raw reads data.The pipeline is written in Nextflow DSL, making it…
View article: Mutational signatures in esophageal squamous cell carcinoma from eight countries with varying incidence
Mutational signatures in esophageal squamous cell carcinoma from eight countries with varying incidence Open
Esophageal squamous cell carcinoma (ESCC) shows remarkable variation in incidence that is not fully explained by known lifestyle and environmental risk factors. It has been speculated that an unknown exogenous exposure(s) could be responsi…
View article: Mutational signatures in esophageal squamous cell carcinoma from eight countries of varying incidence
Mutational signatures in esophageal squamous cell carcinoma from eight countries of varying incidence Open
Esophageal squamous cell carcinoma (ESCC) shows a remarkable variation in incidence which is not fully explained by known lifestyle and environmental risk factors. It has been speculated that an unknown exogenous exposure(s) could be respo…
View article: MSA: Reproducible mutational signature attribution with confidence based on simulations
MSA: Reproducible mutational signature attribution with confidence based on simulations Open
Background Mutational signatures proved to be a useful tool for identifying patterns of mutations in genomes, often providing valuable insights about mutagenic processes or normal DNA damage. De novo extraction of signatures is commonly pe…
View article: Uncovering novel mutational signatures by<i>de novo</i>extraction with SigProfilerExtractor
Uncovering novel mutational signatures by<i>de novo</i>extraction with SigProfilerExtractor Open
SUMMARY Mutational signature analysis is commonly performed in genomic studies surveying cancer and normal somatic tissues. Here we present SigProfilerExtractor, an automated tool for accurate de novo extraction of mutational signatures fo…
View article: A Complete Readout Chain of the ATLAS Tile Calorimeter for the HL-LHC: from FATALIC Front-End Electronics to Signal Reconstruction
A Complete Readout Chain of the ATLAS Tile Calorimeter for the HL-LHC: from FATALIC Front-End Electronics to Signal Reconstruction Open
The ATLAS Collaboration has started a vast programme of upgrades in the context of high-luminosity LHC (HL-LHC) foreseen in 2024. We present here one of the frontend readout options, an ASIC called FATALIC, proposed for the high-luminosity…