Chao Sun
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View article: Combined effects of residual cholesterol inflammatory index and triglyceride-glucose-BMI on risk of cardio-cerebrovascular disease: A cohort study
Combined effects of residual cholesterol inflammatory index and triglyceride-glucose-BMI on risk of cardio-cerebrovascular disease: A cohort study Open
This study aimed to analyze the impact of the residual cholesterol inflammatory index (RCII) and the triglyceride–glucose–body mass index (TyG-BMI) on the risk of cardio-cerebrovascular disease (CCVD). Data were obtained from the China Hea…
View article: Recent advances in the biosynthetic mechanisms, regulation, and detoxification strategies of deoxynivalenol in Fusarium graminearum
Recent advances in the biosynthetic mechanisms, regulation, and detoxification strategies of deoxynivalenol in Fusarium graminearum Open
Fusarium graminearum, the major causal agent of Fusarium head blight (FHB), produces the trichothecene mycotoxin deoxynivalenol (DON), which threatens food and feed safety worldwide. This review synthesizes recent advances in DON biosynthe…
View article: Skeletal muscle abnormalities negatively linked to sleep disturbances in patients with liver cirrhosis: a cross-sectional study
Skeletal muscle abnormalities negatively linked to sleep disturbances in patients with liver cirrhosis: a cross-sectional study Open
Skeletal muscle abnormalities are an independent risk factor for sleep disturbances in cirrhotic patients, highlighting the need for targeted interventions to mitigate muscle abnormalities and potentially enhance sleep quality in this vuln…
View article: Effect of acute kidney injury care bundles on patient prognosis: a systematic review and meta-analysis
Effect of acute kidney injury care bundles on patient prognosis: a systematic review and meta-analysis Open
Not applicable.
View article: Protocol for renal artery embolization via caudal artery in rats
Protocol for renal artery embolization via caudal artery in rats Open
Transvascular embolic materials are vital for acute hemorrhages and tumors, but newly developed materials require preclinical validation. Here, we present a protocol for renal artery embolization through the caudal artery of rats. We descr…
View article: Joint effects of prognostic nutritional index and skeletal muscle index on prognosis of decompensated cirrhosis: a retrospective cohort study
Joint effects of prognostic nutritional index and skeletal muscle index on prognosis of decompensated cirrhosis: a retrospective cohort study Open
Background: Liver cirrhosis, characterized by chronic inflammation, is frequently complicated by malnutrition. Nutritional indices, such as the prognostic nutritional index (PNI) and the skeletal muscle index (SMI), calculated as the muscl…
View article: Exploring the impact of diet, sleep, and metabolomic pathways on Glaucoma subtypes: insights from Mendelian randomization and cross-sectional analyses
Exploring the impact of diet, sleep, and metabolomic pathways on Glaucoma subtypes: insights from Mendelian randomization and cross-sectional analyses Open
Our findings highlight the role of balanced diets and optimized sleep patterns in glaucoma prevention and management. This study provides evidence for targeted lifestyle interventions focusing on metabolic and inflammatory pathways to miti…
View article: Research trends and hotspots of adult Alagille syndrome: a bibliometric analysis
Research trends and hotspots of adult Alagille syndrome: a bibliometric analysis Open
Introduction Alagille syndrome (ALGS) is a complex and rare autosomal dominant disorder that affects multiple systemic organs, including the liver, heart, kidneys, blood vessels, and eyes. However, as a rare disease, adult ALGS is still un…
View article: Smoking-related bladder cancer burden from 1990 to 2021: An age-period-cohort analysis of the global burden of disease study
Smoking-related bladder cancer burden from 1990 to 2021: An age-period-cohort analysis of the global burden of disease study Open
The burden of smoking-related bladder cancer is higher in males, middle-aged and elderly individuals, and medium to high SDI countries. Targeted prevention and health policies are crucial to reducing the disease's impact on populations and…
View article: Alcoholic cirrhosis-associated immune dysfunction: What does it imply for us?
Alcoholic cirrhosis-associated immune dysfunction: What does it imply for us? Open
Alcoholic cirrhosis is a leading cause of chronic advanced liver disease. With the gradual eradication of viral hepatitis and the rising levels of alcohol consumption, the incidence of alcoholic cirrhosis is expected to increase steadily. …
View article: The interplay between trace element zinc and chronic liver diseases: Still water run deep
The interplay between trace element zinc and chronic liver diseases: Still water run deep Open
Zinc is an indispensable trace element that plays a position in regulating human metabolism, immune function, and cell signaling. Zinc homeostasis is indispensible for multiple pathophysiological processes, such as apoptosis, antioxidation…
View article: The Prognostic Significance of Handgrip Strength in Cirrhosis: Simplicity Is the Ultimate Sophistication
The Prognostic Significance of Handgrip Strength in Cirrhosis: Simplicity Is the Ultimate Sophistication Open
Cirrhosis serves as the final stage of various chronic liver damage, accounting for around one million deaths annually in the world. Given the clinical significance and the imperative to relieve this social as well as healthcare burden in …
View article: Association between TyG-BMI and BPH in a national prospective cohort study
Association between TyG-BMI and BPH in a national prospective cohort study Open
This study aims to explore the relationship between the Triglyceride Glucose Body Mass Index (TyG-BMI) and the risk of developing benign prostatic hyperplasia (BPH). Utilizing data from the China Health and Retirement Longitudinal Study (C…
View article: Improved Discrimination and Predictive Ability of Novel Prognostic Scores for Long-term Mortality in Hospitalized Patients with Cirrhosis
Improved Discrimination and Predictive Ability of Novel Prognostic Scores for Long-term Mortality in Hospitalized Patients with Cirrhosis Open
MELD 3.0 is superior to other MELD-based scores for long-term prognostication in hospitalized patients with cirrhosis, while GEMA-Na demonstrated even better accuracy and performance.
View article: Mixture of Experts Framework Based on Soft Actor-Critic Algorithm for Highway Decision-Making of Connected and Automated Vehicles
Mixture of Experts Framework Based on Soft Actor-Critic Algorithm for Highway Decision-Making of Connected and Automated Vehicles Open
Decision-making of connected and automated vehicles (CAV) includes a sequence of driving maneuvers that improve safety and efficiency, characterized by complex scenarios, strong uncertainty, and high real-time requirements. Deep reinforcem…
View article: Development and external validation of Global Leadership Initiative on Malnutrition-dictated nomograms predicting long-term mortality in hospitalized patients with cirrhosis
Development and external validation of Global Leadership Initiative on Malnutrition-dictated nomograms predicting long-term mortality in hospitalized patients with cirrhosis Open
Objectives Global Leadership Initiative on Malnutrition (GLIM) criteria have gradually accounted for the mainstay evaluating nutritional status. We sought to establish GLIM-dictated nomograms with other prognostic factors influencing long-…
View article: The Development and Appraisal of MELD 3.0 in Liver Diseases: Good Things Never Come Easy
The Development and Appraisal of MELD 3.0 in Liver Diseases: Good Things Never Come Easy Open
Since its proposal, the Model for End-Stage Liver Disease (MELD) score has been employed to predict short-term mortality among patients with chronic liver disease and those awaiting liver transplantation, serving as the primary criterion f…
View article: An Expanded Substrate Spectrum of Sulfide:Quinone Oxidoreductase Found in Pollutant Degrading Bacteria
An Expanded Substrate Spectrum of Sulfide:Quinone Oxidoreductase Found in Pollutant Degrading Bacteria Open
Sulfide:Quinone Oxidoreductase (Sqr) Catalyzes The Initial Procedure On Sulfide Transformation, Alongside Sulfide (H 2 S, S 2− ) Oxidization Coupled With Coenzyme Q (CoQ) Reducing And Reactive Sulfur Species (RSS) Production. Here, We Asse…
View article: Development and validation of an explainable machine learning model for predicting multidimensional frailty in hospitalized patients with cirrhosis
Development and validation of an explainable machine learning model for predicting multidimensional frailty in hospitalized patients with cirrhosis Open
We sought to develop and validate a machine learning (ML) model for predicting multidimensional frailty based on clinical and laboratory data. Moreover, an explainable ML model utilizing SHapley Additive exPlanations (SHAP) was constructed…
View article: Linear relation association between TyG-BMI and BPH: a national prospective cohort study
Linear relation association between TyG-BMI and BPH: a national prospective cohort study Open
Objective This study aims to explore the relationship between the Triglyceride Glucose Body Mass Index (TyG-BMI) and the risk of developing benign prostatic hyperplasia (BPH). Methods Utilizing data from the China Health and Retirement Lon…