Explanipedia

A comparison of the pharmacological profiles of prasugrel and ticagrelor assessed by platelet aggregation, thrombus formation and haemostasis in rats Open

Atsuhiro Sugidachi, Kinji Ohno, Taketoshi Ogawa, J.A. Jakubowski, Masami Hashimoto , et al. · 2013

Background and Purpose Prasugrel is a third‐generation thienopyridine prodrug and ticagrelor is a non‐competitive P2Y 12 receptor antagonist. In their phase 3 studies, both agents reduced rates of ischemic events relative to treatment with…

Inhibition of coagulation and thrombin-induced platelet activities by a synthetic dodecapeptide modeled on the carboxy-terminus of hirudin Open

J.A. Jakubowski, JM Maraganore · 1990

A synthetic, tyrosine-sulfated, dodecapeptide (BG8865) modeled on residues 53–64 of hirudin was found to elevate the activated partial thromboplastin time (APTT), prothrombin time (PT), and thrombin time (TT) of human plasma in a dose-depe…

Elevated glucose alters eicosanoid release from porcine aortic endothelial cells. Open

Michael L. Brown, J.A. Jakubowski, Lynn L. Leventis, Daniel Deykin · 1988

Cultured porcine aortic endothelial cells were conditioned through two passages to mimic euglycemic and hyperglycemic conditions (5.2 mM, normal glucose; 15.6 mM, elevated glucose). After incubation with 1 microM [14C]arachidonic acid for …

The pathophysiology and clinical relevance of platelet heterogeneity Open

C. Mildred Thompson, J.A. Jakubowski · 1988

Recent studies on platelet heterogeneity support the hypothesis that platelet production is regulated to maintain a constant functional platelet mass. In concept this form of regulation is analogous to the manner by which RBC production is…

The pathophysiology and clinical relevance of platelet heterogeneity Open

Thompson Cb, J.A. Jakubowski · 1988

Recent studies on platelet heterogeneity support the hypothesis that platelet production is regulated to maintain a constant functional platelet mass. In concept this form of regulation is analogous to the manner by which RBC production is…

Effects of insulin and prior exercise on prostaglandin release from perfused rat muscle Evidence that prostaglandins do not mediate changes in glucose uptake Open

António Zorzano, T. W. Balon, J.A. Jakubowski, M. N. Goodman, Daniel Deykin , et al. · 1986

Prostaglandin generation and its inter-relation to the metabolic effects of insulin and prior exercise were examined in perfused muscle of fed rats. During a 60 min perfusion of the rat hindquarter, a substantial release of the prostagland…

Platelet size and age determine platelet function independently Open

Thompson Cb, J.A. Jakubowski, P. Quinn, Daniel Deykin, C. R. Valeri · 1984

This study was undertaken to examine the interaction of platelet size and age in determining in vitro platelet function. Baboon megakaryocytes were labeled in vivo by the injection of 75Se- methionine. Blood was collected when the label wa…

Platelet size and age determine platelet function independently Open

C. Mildred Thompson, J.A. Jakubowski, P. Quinn, D Deykin, C. R. Valeri · 1984

This study was undertaken to examine the interaction of platelet size and age in determining in vitro platelet function. Baboon megakaryocytes were labeled in vivo by the injection of 75Se- methionine. Blood was collected when the label wa…

Effect of membrane cholesterol on phospholipid metabolism in thrombin-stimulated platelets. Enhanced activation of platelet phospholipase(s) for liberation of arachidonic acid. Open

Ruth M. Kramer, J.A. Jakubowski, R. Vaillancourt, Daniel Deykin · 1982

The cholesterol to phospholipid mole ratio (C/PL) of human platelets was increased 1.3-fold or maintained at a normal value by incubating platelets with sonicated dispersions of cholesterol and phosphatidylcholine (PC) (C/PL = 3 or 1, resp…

Production Of Thromboxane B2 By Platelets Is Related To Their Density Open

J.F. Martin, Tanya J. Shaw, J.A. Jakubowski, D. G. Penington, T. John Martin · 1981

Platelets of different densities are probably produced from megakaryocytes of different ploidy. Thromboxane B2 (TxB2) production was studied in density dependent subfractions of the total platelet population. Platelets were isolated by a n…

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