Jaaved Mohammed
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View article: The craniofacial shape of modern humans embodies genomic signatures of evolution, diversity, and clinical conditions
The craniofacial shape of modern humans embodies genomic signatures of evolution, diversity, and clinical conditions Open
Human craniofacial morphology is a hallmark of our species’ diversity and evolutionary history, shaped by adaptation, introgression, and global dispersal. Cranial globularization and chin emergence are well-documented morphological transfo…
View article: The rapidly evolving X-linked MIR-506 family fine-tunes spermatogenesis to enhance sperm competition
The rapidly evolving X-linked MIR-506 family fine-tunes spermatogenesis to enhance sperm competition Open
Despite rapid evolution across eutherian mammals, the X-linked MIR-506 family miRNAs are located in a region flanked by two highly conserved protein-coding genes ( SLITRK2 and FMR1 ) on the X chromosome. Intriguingly, these miRNAs are pred…
View article: The Rapidly Evolving X-linked miR-506 Family Finetunes Spermatogenesis to Enhance Sperm Competition
The Rapidly Evolving X-linked miR-506 Family Finetunes Spermatogenesis to Enhance Sperm Competition Open
Despite rapid evolution across eutherian mammals, the X-linked miR-506 family miRNAs are located in a region flanked by two highly conserved protein-coding genes (Slitrk2 and Fmr1) on the X chromosome. Intriguingly, these miRNAs are predom…
View article: Author Response: The Rapidly Evolving X-linked miR-506 Family Finetunes Spermatogenesis to Enhance Sperm Competition
Author Response: The Rapidly Evolving X-linked miR-506 Family Finetunes Spermatogenesis to Enhance Sperm Competition Open
Despite rapid evolution across eutherian mammals, the X-linked miR-506 family miRNAs are located in a region flanked by two highly conserved protein-coding genes (Slitrk2 and Fmr1) on the X chromosome. Intriguingly, these miRNAs are predom…
View article: A common cis-regulatory variant impacts normal-range and disease-associated human facial shape through regulation of PKDCC during chondrogenesis
A common cis-regulatory variant impacts normal-range and disease-associated human facial shape through regulation of PKDCC during chondrogenesis Open
Genome-wide association studies (GWAS) identified thousands of genetic variants linked to phenotypic traits and disease risk. However, mechanistic understanding of how GWAS variants influence complex morphological traits and can, in certai…
View article: The rapidly evolving X-linked MIR-506 family fine-tunes spermatogenesis to enhance sperm competition
The rapidly evolving X-linked MIR-506 family fine-tunes spermatogenesis to enhance sperm competition Open
Despite rapid evolution across eutherian mammals, the X-linked MIR-506 family miRNAs are located in a region flanked by two highly conserved protein-coding genes ( SLITRK2 and FMR1 ) on the X chromosome. Intriguingly, these miRNAs are pred…
View article: The Rapidly Evolving X-linked miR-506 Family Finetunes Spermatogenesis to Enhance Sperm Competition
The Rapidly Evolving X-linked miR-506 Family Finetunes Spermatogenesis to Enhance Sperm Competition Open
Despite rapid evolution across eutherian mammals, the X-linked miR-506 family miRNAs are located in a region flanked by two highly conserved protein-coding genes (Slitrk2 and Fmr1) on the X chromosome. Intriguingly, these miRNAs are predom…
View article: A genome-wide genetic screen uncovers determinants of human pigmentation
A genome-wide genetic screen uncovers determinants of human pigmentation Open
Skin color, one of the most diverse human traits, is determined by the quantity, type, and distribution of melanin. In this study, we leveraged the light-scattering properties of melanin to conduct a genome-wide screen for regulators of me…
View article: The Rapidly Evolving X-linked <i>miR-506</i> Family Finetunes Spermatogenesis to Enhance Sperm Competition
The Rapidly Evolving X-linked <i>miR-506</i> Family Finetunes Spermatogenesis to Enhance Sperm Competition Open
Despite rapid evolution across eutherian mammals, the X-linked miR-506 family miRNAs are located in a region flanked by two highly conserved protein-coding genes ( Slitrk2 and Fmr1 ) on the X chromosome. Intriguingly, these miRNAs are pred…
View article: A common <i>cis</i> -regulatory variant impacts normal-range and disease-associated human facial shape through regulation of <i>PKDCC</i> during chondrogenesis
A common <i>cis</i> -regulatory variant impacts normal-range and disease-associated human facial shape through regulation of <i>PKDCC</i> during chondrogenesis Open
Genome-wide association studies (GWAS) identified thousands of genetic variants linked to phenotypic traits and disease risk. However, mechanistic understanding of how GWAS variants influence complex morphological traits and can, in certai…
View article: Making the Human Face: Elucidating the Role of Enhancers in Hominid Craniofacial Evolution
Making the Human Face: Elucidating the Role of Enhancers in Hominid Craniofacial Evolution Open
There is increasing evidence that morphological differences among individuals of the same species and between species are driven by changes in gene expression mediated by non‐coding mutations that are enriched at enhancer elements. The ide…
View article: A genome-wide genetic screen uncovers novel determinants of human pigmentation
A genome-wide genetic screen uncovers novel determinants of human pigmentation Open
The skin color is one of the most diverse human traits and is determined by the quantity, type and distribution of melanin. Here, we leverage light scattering properties of melanin to conduct a genome-wide CRISPR-Cas9 screen for novel regu…
View article: Genome scans of facial features in East Africans and cross-population comparisons reveal novel associations
Genome scans of facial features in East Africans and cross-population comparisons reveal novel associations Open
Facial morphology is highly variable, both within and among human populations, and a sizable portion of this variation is attributable to genetics. Previous genome scans have revealed more than 100 genetic loci associated with different as…
View article: FaceBase 3: analytical tools and FAIR resources for craniofacial and dental research
FaceBase 3: analytical tools and FAIR resources for craniofacial and dental research Open
The FaceBase Consortium was established by the National Institute of Dental and Craniofacial Research in 2009 as a ‘big data’ resource for the craniofacial research community. Over the past decade, researchers have deposited hundreds of an…
View article: Insights into the genetic architecture of the human face
Insights into the genetic architecture of the human face Open
The human face is complex and multipartite, and characterization of its genetic architecture remains intriguingly challenging. Applying GWAS to multivariate shape phenotypes, we identified 203 genomic regions associated with normal-range f…
View article: Erratum: Deep experimental profiling of microRNA diversity, deployment, and evolution across the <i>Drosophila</i> genus
Erratum: Deep experimental profiling of microRNA diversity, deployment, and evolution across the <i>Drosophila</i> genus Open
In the above-mentioned article, one of the coauthor names was misspelled and has now been corrected online as Md Mosharrof Hossain Mondal.
View article: Deep experimental profiling of microRNA diversity, deployment, and evolution across the <i>Drosophila</i> genus
Deep experimental profiling of microRNA diversity, deployment, and evolution across the <i>Drosophila</i> genus Open
To assess miRNA evolution across the Drosophila genus, we analyzed several billion small RNA reads across 12 fruit fly species. These data permit comprehensive curation of species- and clade-specific variation in miRNA identity, abundance,…
View article: New genes often acquire male-specific functions but rarely become essential in <i>Drosophila</i>
New genes often acquire male-specific functions but rarely become essential in <i>Drosophila</i> Open
Relatively little is known about the in vivo functions of newly emerging genes, especially in metazoans. Although prior RNAi studies reported prevalent lethality among young gene knockdowns, our phylogenomic analyses reveal that young Dros…
View article: Deep experimental profiling of microRNA diversity, deployment, and evolution across the<i>Drosophila</i>genus
Deep experimental profiling of microRNA diversity, deployment, and evolution across the<i>Drosophila</i>genus Open
Comparative genomic analyses of microRNAs (miRNAs) have yielded myriad insights into their biogenesis and regulatory activity. While miRNAs have been deeply annotated in a small cohort of model organisms, evolutionary assessments of miRNA …
View article: Evolution Of Micrornas In Drosophila
Evolution Of Micrornas In Drosophila Open
The molecular evolutionary signatures of miRNAs inform our understanding of their emergence, biogenesis, and function. In this work, we use methods and principles from comparative and population genomics, molecular biology, and genetics to…