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View article: The Plasmodium CSP repeats have elastic properties with a critical role in sporozoite motility
The Plasmodium CSP repeats have elastic properties with a critical role in sporozoite motility Open
The Plasmodium circumsporozoite protein (CSP) is the major surface protein of the sporozoite, the infective stage of the malaria parasite. The central repeat region of CSP is the primary immunological target of the sporozoite stage, yet li…
View article: Single molecule studies of the native hair cell mechanosensory transduction complex
Single molecule studies of the native hair cell mechanosensory transduction complex Open
Hearing and balance rely on the conversion of a mechanical stimulus into an electrical signal, a process known as mechanosensory transduction (MT). In vertebrates, this process is accomplished by an MT complex that is located in hair cells…
View article: DNA Damage-Induced, S-Phase Specific Phosphorylation of Orc6 is Critical for the Maintenance of Genome Stability
DNA Damage-Induced, S-Phase Specific Phosphorylation of Orc6 is Critical for the Maintenance of Genome Stability Open
The smallest subunit of the human Origin Recognition Complex, hOrc6, is required for DNA replication progression and plays an important role in mismatch repair (MMR) during S-phase. However, the molecular details of how hOrc6 regulates DNA…
View article: Enhanced mTORC1 signaling and Protein Synthesis in Parkinson’s Disease Pathogenesis Disease Pathogenesis
Enhanced mTORC1 signaling and Protein Synthesis in Parkinson’s Disease Pathogenesis Disease Pathogenesis Open
Pathologic α-syn destabilizes the TSC 1 and 2 complex leading to mTORC1 activation, enhanced protein translation and neurodegeneration in PD. Abstract: Pathological α-synuclein (α-syn) plays an important role in the pathogenesis of α-synuc…
View article: Reliability and accuracy of single-molecule FRET studies for characterization of structural dynamics and distances in proteins
Reliability and accuracy of single-molecule FRET studies for characterization of structural dynamics and distances in proteins Open
Single-molecule FRET (smFRET) has become an established tool to study biomolecular structure and dynamics in vitro and in live cells. We performed a worldwide blind study involving 19 labs to assess the uncertainty of FRET experiments for …
View article: Orc6 is a component of the replication fork and enables efficient mismatch repair
Orc6 is a component of the replication fork and enables efficient mismatch repair Open
Significance Origin recognition complex (ORC) is required for the initiation of DNA replication. Unlike other ORC components, the role of human Orc6 in replication remains to be resolved. We identified an unexpected role for hOrc6, which i…
View article: The repeat region of the circumsporozoite protein is an elastic linear spring with a functional role in <i>Plasmodium</i> sporozoite motility
The repeat region of the circumsporozoite protein is an elastic linear spring with a functional role in <i>Plasmodium</i> sporozoite motility Open
The circumsporozoite protein (CSP) forms a dense coat on the surface of the sporozoite, the infective stage of the malaria parasite. The central repeat region of CSP is a critical component of the only licensed malaria vaccine yet little i…
View article: Orc6 at replication fork enables efficient mismatch repair
Orc6 at replication fork enables efficient mismatch repair Open
In eukaryotes, the Origin Recognition Complex (ORC) is required for the initiation of DNA replication. The smallest subunit of ORC, Orc6, is essential for pre-replication complex (pre-RC) assembly and cell viability in yeast and for cytoki…
View article: Controlling the macroscopic electrical properties of reduced graphene oxide by nanoscale writing of electronic channels
Controlling the macroscopic electrical properties of reduced graphene oxide by nanoscale writing of electronic channels Open
The allure of all-carbon electronics stems from the spread of its physical properties across all its allotropes. The scheme also harbours unique challenges, such as tunability of band gap, variability of doping and defect control. Here, we…
View article: Increasing kinase domain proximity promotes MST2 autophosphorylation during Hippo signaling
Increasing kinase domain proximity promotes MST2 autophosphorylation during Hippo signaling Open
The Hippo pathway plays an important role in developmental biology, mediating organ size by controlling cell proliferation through the activity of a core kinase cassette. Multiple upstream events activate the pathway, but how each controls…
View article: ORCA/LRWD1 Regulates Homologous Recombination at ALT-Telomeres by Modulating Heterochromatin Organization
ORCA/LRWD1 Regulates Homologous Recombination at ALT-Telomeres by Modulating Heterochromatin Organization Open
Telomeres are maintained by telomerase or in a subset of cancer cells by a homologous recombination (HR)-based mechanism, Alternative Lengthening of Telomeres (ALT). The mechanisms regulating telomere-homeostasis in ALT cells remain unclea…
View article: Streamlining effects of extra telomeric repeat on telomeric DNA folding revealed by fluorescence-force spectroscopy
Streamlining effects of extra telomeric repeat on telomeric DNA folding revealed by fluorescence-force spectroscopy Open
A human telomere ends in a single-stranded 3′ tail, composed of repeats of T2AG3. G-quadruplexes (GQs) formed from four consecutive repeats have been shown to possess high-structural and mechanical diversity. In principle, a GQ can form fr…
View article: Streamlining effects of extra telomeric repeat on telomere folding revealed by fluorescence-force spectroscopy
Streamlining effects of extra telomeric repeat on telomere folding revealed by fluorescence-force spectroscopy Open
Tandem repeats of guanine rich sequences are ubiquitous in the eukaryotic genome. For example, in the human cells, telomeres at the chromosomal ends comprise of kilobases repeats of T 2 AG 3 . Four such repeats can form G-quadruplexes (GQs…
View article: Nanomechanics and co-transcriptional folding of Spinach and Mango
Nanomechanics and co-transcriptional folding of Spinach and Mango Open
Recent advances in fluorogen-binding RNA aptamers known as “light-up” aptamers provide an avenue for protein-free detection of RNA in cells. Crystallographic studies have revealed a G-Quadruplex (GQ) structure at the core of light-up aptam…
View article: Extreme mechanical diversity of human telomeric DNA revealed by fluorescence-force spectroscopy
Extreme mechanical diversity of human telomeric DNA revealed by fluorescence-force spectroscopy Open
Significance G-quadruplex (GQ)–forming G4 DNA, made of four repeats of guanines, is implicated in many important processes. Telomeric GQs are being studied extensively as anticancer drug targets. Because many nucleic acid-processing enzyme…
View article: Functional instability allows access to DNA in longer transcription Activator-Like effector (TALE) arrays
Functional instability allows access to DNA in longer transcription Activator-Like effector (TALE) arrays Open
Transcription activator-like effectors (TALEs) bind DNA through an array of tandem 34-residue repeats. How TALE repeat domains wrap around DNA, often extending more than 1.5 helical turns, without using external energy is not well understo…
View article: Author response: Functional instability allows access to DNA in longer transcription Activator-Like effector (TALE) arrays
Author response: Functional instability allows access to DNA in longer transcription Activator-Like effector (TALE) arrays Open
Article Figures and data Abstract eLife digest Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Transcription activator-like …
View article: Kaposi's Sarcoma-Associated Herpesvirus Viral Interferon Regulatory Factor 4 (vIRF4) Perturbs the G <sub>1</sub> -S Cell Cycle Progression via Deregulation of the <i>cyclin D1</i> Gene
Kaposi's Sarcoma-Associated Herpesvirus Viral Interferon Regulatory Factor 4 (vIRF4) Perturbs the G <sub>1</sub> -S Cell Cycle Progression via Deregulation of the <i>cyclin D1</i> Gene Open
Kaposi's sarcoma-associated herpesvirus (KSHV) infection modulates the host cell cycle to create an environment optimal for its viral-DNA replication during the lytic life cycle. We report here that KSHV vIRF4 targets the β-catenin/CBP cof…