Jacek Fijuth
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View article: Real-world survival and prognostic factors in WHO 2021 classified gliomas treated with chemo-radiotherapy
Real-world survival and prognostic factors in WHO 2021 classified gliomas treated with chemo-radiotherapy Open
The 2021 WHO glioma classification integrates molecular profiling, but outcome data for these patients are limited. We retrospectively analyzed 179 patients (median age 53) with WHO 2021-classified gliomas (grade 2: n = 45, grade 3: n = 51…
View article: EP12.04 REAL-WORLD SURVIVAL OUTCOMES AFTER (CHEMO)RADIOTHERAPY FOR WHO 2021-CLASSIFIED GLIOMAS: A MULTICENTER ANALYSIS OF CLINICAL, TREATMENT-RELATED, DOSIMETRIC, AND HEMATOLOGIC PROGNOSTIC FACTORS
EP12.04 REAL-WORLD SURVIVAL OUTCOMES AFTER (CHEMO)RADIOTHERAPY FOR WHO 2021-CLASSIFIED GLIOMAS: A MULTICENTER ANALYSIS OF CLINICAL, TREATMENT-RELATED, DOSIMETRIC, AND HEMATOLOGIC PROGNOSTIC FACTORS Open
BACKGROUND The 2021 WHO classification of gliomas introduced molecular profiling into the diagnostic criteria, reshaping prognosis and therapeutic strategies. However, most existing outcomes data are based on previous classifications, crea…
View article: CARBOMETASPINE: protocol for a multicenter, prospective, randomized controlled trial of carbonfiber spinal fixation in metastatic disease
CARBOMETASPINE: protocol for a multicenter, prospective, randomized controlled trial of carbonfiber spinal fixation in metastatic disease Open
Background Spinal metastases frequently cause neurological compromise and mechanical instability. Titanium fixation limits postoperative imaging and hinders stereotactic body radiotherapy (SBRT) planning because of artefacts. Methods CARBO…
View article: Cemiplimab in monotherapy and in combination with chemotherapy for patients with non-small cell lung cancer according to an actual drug program for the treatment of lung cancer and pleural mesothelioma
Cemiplimab in monotherapy and in combination with chemotherapy for patients with non-small cell lung cancer according to an actual drug program for the treatment of lung cancer and pleural mesothelioma Open
View article: Real-World Survival Outcomes After (Chemo)radiotherapy for WHO 2021-Classified Gliomas: A Multicenter Analysis of Clinical, Treatment-Related, Dosimetric, and Hematologic Prognostic Factors
Real-World Survival Outcomes After (Chemo)radiotherapy for WHO 2021-Classified Gliomas: A Multicenter Analysis of Clinical, Treatment-Related, Dosimetric, and Hematologic Prognostic Factors Open
The 2021 WHO glioma classification integrates molecular profiling, but outcome data for these patients are limited. We retrospectively analyzed 179 patients (median age 53) with WHO 2021-classified gliomas (grade 2: n = 45, grade 3: n = 51…
View article: Comprehensive cohort study: computer tomography-guided high-dose rate brachytherapy as metastasis-directed therapy for liver metastases from colorectal cancer in repeat oligoprogression
Comprehensive cohort study: computer tomography-guided high-dose rate brachytherapy as metastasis-directed therapy for liver metastases from colorectal cancer in repeat oligoprogression Open
View article: Recommendations of the Expert Panel and the Polish Lung Cancer Study Group on the use of chemotherapy in combination with osimertinib for treatment of non-small cell lung cancer patients with pathogenic variants of the EGFR gene
Recommendations of the Expert Panel and the Polish Lung Cancer Study Group on the use of chemotherapy in combination with osimertinib for treatment of non-small cell lung cancer patients with pathogenic variants of the EGFR gene Open
View article: Hippocampal protection during preventive cranial irradiation and neurocognitive functions in patients with small cell lung cancer
Hippocampal protection during preventive cranial irradiation and neurocognitive functions in patients with small cell lung cancer Open
Following PCI, SCLC patients experience significant cognitive decline, even when the radiation dose in the hippocampal area is reduced. This trend continues for at least 3 months following the PCI. In hippocampal-protected patients signifi…
View article: miR-200 family as new potential prognostic factor of overall survival of patients with WHO G2 and WHO G3 brain gliomas
miR-200 family as new potential prognostic factor of overall survival of patients with WHO G2 and WHO G3 brain gliomas Open
Purpose Gliomas are the predominant cause of cancer-related deaths among the young population. Even after incorporation of IDH1/2 mutations and 1p19q codeletion there are doubts regarding adjuvant treatment in WHO G2/G3 gliomas. miRNA mole…
View article: Half body irradiation (HBI) for bone metastases in the modern radiotherapy technique era – A systematic review
Half body irradiation (HBI) for bone metastases in the modern radiotherapy technique era – A systematic review Open
View article: Early lymphocyte levels and low doses radiation exposure of lung predict lymphopenia in radiotherapy for lung cancer
Early lymphocyte levels and low doses radiation exposure of lung predict lymphopenia in radiotherapy for lung cancer Open
Introduction Radiation induced lymphopenia (RIL) deteriorate survival and diminishes the benefit of immune checkpoint inhibitors in combined treatment of lung cancer. Given the inconsistent data across various studies on the predictors of …
View article: Predicting of overall survival in non-small cell lung cancer patients receiving concurrent radiochemotherapy and adjuvant durvalumab – a Polish real-world single-center experience
Predicting of overall survival in non-small cell lung cancer patients receiving concurrent radiochemotherapy and adjuvant durvalumab – a Polish real-world single-center experience Open
Introduction.Adjuvant durvalumab has become a standard treatment protocol for patients with locally advanced non-small cell lung cancer (LA-NSCLC). However, there is still limited knowledge about prognostic factors in a real-world setting …
View article: High <i>FLT3</i> expression increases immune‐cell infiltration in the tumor microenvironment and correlates with prolonged disease‐free survival in patients with non‐small cell lung cancer
High <i>FLT3</i> expression increases immune‐cell infiltration in the tumor microenvironment and correlates with prolonged disease‐free survival in patients with non‐small cell lung cancer Open
Most of the currently used cancer immunotherapies inhibit the programmed cell death protein 1 (PD1)–programmed cell death 1 ligand 1 (PDL1) axis of T‐cells. However, dendritic cells (DCs) controlled by natural killer (NK) cells via the FMS…
View article: Carbon fiber transpedicular screws in the treatment of spinal metastatic disease and stereotactic radiotherapy - the prospective, randomized trial protocol
Carbon fiber transpedicular screws in the treatment of spinal metastatic disease and stereotactic radiotherapy - the prospective, randomized trial protocol Open
View article: Algorithms of follow-up in patients with head and neck cancer in relation to primary location and advancement. Consensus of Polish ENT Society Board and Head Neck Experts
Algorithms of follow-up in patients with head and neck cancer in relation to primary location and advancement. Consensus of Polish ENT Society Board and Head Neck Experts Open
Summary The algorithm of follow-up in patients with head and neck cancer (HNC) has been prepared by a board of Polish Head Neck and Oncology Experts. The aim of this research is to focus on the specificity of HNC monitoring, to review the …
View article: Extreme acute radiation‐induced toxicity in a patient with polymorphous low‐grade adenocarcinoma of the nasopharynx and rare variants in <scp>DNA</scp> repair genes
Extreme acute radiation‐induced toxicity in a patient with polymorphous low‐grade adenocarcinoma of the nasopharynx and rare variants in <span>DNA</span> repair genes Open
Background Polymorphous low‐grade adenocarcinoma (PLGA) is an extremely rare finding in the nasopharynx. There are no guidelines for the treatment of PLGA in this localization. Radiotherapy may be administered to treat this malignancy; how…
View article: The effect of hippocampal sparing during prophylactic cranial irradiation on the preservation of neurocognitive functions in patients with small cell lung cancer: a preliminary study
The effect of hippocampal sparing during prophylactic cranial irradiation on the preservation of neurocognitive functions in patients with small cell lung cancer: a preliminary study Open
Summary: Prophylactic cerebral irradiation (PCI) is the standard of care for patients with limited small cell lung cancer (SCLC). Cerebral irradiation is associated with deterioration of patients' quality of life in terms of cognitive func…
View article: Predicting neutropenia dynamics after radiation therapy in multiple myeloma patients receiving first-line bortezomib-based chemotherapy – a pilot study
Predicting neutropenia dynamics after radiation therapy in multiple myeloma patients receiving first-line bortezomib-based chemotherapy – a pilot study Open
INTRODUCTION: Radiation therapy (RT) is a useful modality for achieving local control and symptom relief in patients with multiple myeloma (MM), but its use can result in adverse effects such as neutropenia, which may be aggravated by prio…
View article: The role of PET/CT with fluorine-18-deoxyglucose in the detection of relapsed serous ovarian cancer in patients with normal serum CA125 levels
The role of PET/CT with fluorine-18-deoxyglucose in the detection of relapsed serous ovarian cancer in patients with normal serum CA125 levels Open
In patients with a diagnosis of complete remission after treatment for serous ovarian cancer, even a multifocal recurrence may occur during follow up despite normal serum CA125 levels. Our results showed a usefulness of the PET/CT in detec…
View article: Potential Prognostic Value of GATA4 Depends on the p53 Expression in Primary Glioblastoma Patients
Potential Prognostic Value of GATA4 Depends on the p53 Expression in Primary Glioblastoma Patients Open
Background: Primary glioblastoma is characterized by an extremely poor prognosis. The promoter methylation of GATA4 leads to the loss of its expression in many cancer types. The formation of high-grade astrocytomas can be promoted by the c…
View article: Radiation-induced circulating microRNAs linked to echocardiography parameters after radiotherapy
Radiation-induced circulating microRNAs linked to echocardiography parameters after radiotherapy Open
Introduction Patients treated with radiotherapy to the chest region are at risk of cardiac sequelae, however, identification of those with greatest risk of complications remains difficult. Here, we sought to determine whether short-term ch…
View article: The value of [18F]FDG PET/CT examination in the detection and differentiation of recurrent ovarian cancer
The value of [18F]FDG PET/CT examination in the detection and differentiation of recurrent ovarian cancer Open
A high frequency of recurrent ovarian cancer detected in the [18F]FDG PET/CT examinations due to increased Ca 125 concentration in patients without clinical symptoms and without changes in other imaging tests confirmed the usefulness of [1…
View article: Prospective analysis of the impact of adjuvant treatment with external beam radiation therapy and vaginal brachytherapy on health-related quality of life in patients with early-stage endometrioid endometrial carcinoma
Prospective analysis of the impact of adjuvant treatment with external beam radiation therapy and vaginal brachytherapy on health-related quality of life in patients with early-stage endometrioid endometrial carcinoma Open
Adjuvant radiotherapy in patients with early-stage endometrioid endometrial cancer after hysterectomy is associated with worse quality of life, especially due to the toxicity of the treatment in relation to the gastrointestinal tract and u…
View article: QUAD SHOT – an effective hypofractionated palliative radiotherapy in patients with non-melanoma skin cancer. A single-institution experience
QUAD SHOT – an effective hypofractionated palliative radiotherapy in patients with non-melanoma skin cancer. A single-institution experience Open
QUAD SHOT schedule with VMAT RT may be an effective palliative treatment method with a good response rate, which positively affects patients' quality of life in locally advanced non-melanoma skin cancer patients disqualified from surgery.
View article: Retrospective analysis of the effectiveness of volumetric modulated arc therapy half‑body irradiation in palliation of pain in patients with multiple bone metastases
Retrospective analysis of the effectiveness of volumetric modulated arc therapy half‑body irradiation in palliation of pain in patients with multiple bone metastases Open
Bone metastases are the most common cause of cancer-related pain. It has been reported that radiotherapy is efficient in the palliation of pain caused by bone metastases. Half-body irradiation (HBI) is a method of palliative treatment in p…
View article: The Kinetics of FMS-Related Tyrosine Kinase 3 Ligand (Flt-3L) during Chemoradiotherapy Suggests a Potential Gain from the Earlier Initiation of Immunotherapy
The Kinetics of FMS-Related Tyrosine Kinase 3 Ligand (Flt-3L) during Chemoradiotherapy Suggests a Potential Gain from the Earlier Initiation of Immunotherapy Open
The optimal sequence of chemoradiotherapy with immunotherapy is still not established. The patient’s immune status may play a role in determining this order. We aim to determine the kinetics of a multi-potential haemopoietic factor FMS-rel…
View article: Prediction of Radiation-Induced Hypothyroidism Using Radiomic Data Analysis Does Not Show Superiority over Standard Normal Tissue Complication Models
Prediction of Radiation-Induced Hypothyroidism Using Radiomic Data Analysis Does Not Show Superiority over Standard Normal Tissue Complication Models Open
State-of-art normal tissue complication probability (NTCP) models do not take into account more complex individual anatomical variations, which can be objectively quantitated and compared in radiomic analysis. The goal of this project was …
View article: Assessment of cervical vascularization density in patients with locally advanced squamous cell cervical carcinoma evaluated in colour Doppler and power Doppler functions
Assessment of cervical vascularization density in patients with locally advanced squamous cell cervical carcinoma evaluated in colour Doppler and power Doppler functions Open
Purpose The aim of the prospective study was to assess changes during treatment and prognostic significance of cervical vascularization density in patients with cervical squamous cell carcinoma (SCC) staged II B and III B and to find relat…
View article: Prediction of radiation-induced hypothyroidism using radiomic data analysis does not show superiority over standard normal tissue complication models
Prediction of radiation-induced hypothyroidism using radiomic data analysis does not show superiority over standard normal tissue complication models Open
State-of-art normal tissue complication probability (NTCP) models do not take into account more complex individual anatomical variations, which can be objectively quantitated and compared in radiomic analysis. The goal of this project was …
View article: Cardiovascular Safety of Degarelix Versus Leuprolide in Patients With Prostate Cancer: The Primary Results of the PRONOUNCE Randomized Trial
Cardiovascular Safety of Degarelix Versus Leuprolide in Patients With Prostate Cancer: The Primary Results of the PRONOUNCE Randomized Trial Open
Background: The relative cardiovascular safety of gonadotropin-releasing hormone (GnRH) antagonists compared with GnRH agonists in men with prostate cancer and known atherosclerotic cardiovascular disease remains controversial. Methods: In…