Jack Adderley
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View article: A timeline of reckoning: Tracking the historical rise of antimicrobial resistance across HIV, TB, and malaria
A timeline of reckoning: Tracking the historical rise of antimicrobial resistance across HIV, TB, and malaria Open
Antimicrobial resistance is one of the major health challenges of this century. Here, we provide an in-depth perspective on the evolution of antimicrobial resistance in three globally relevant infectious diseases, HIV, tuberculosis (TB), a…
View article: A Plasmodium falciparum MORC protein complex modulates epigenetic control of gene expression through interaction with heterochromatin
A Plasmodium falciparum MORC protein complex modulates epigenetic control of gene expression through interaction with heterochromatin Open
Dynamic control of gene expression is critical for blood stage development of malaria parasites. Here, we used multi-omic analyses to investigate transcriptional regulation by the chromatin-associated microrchidia protein, MORC, during ase…
View article: Reviewer #1 (Public Review): A Plasmodium falciparum MORC protein complex modulates epigenetic control of gene expression through interaction with heterochromatin
Reviewer #1 (Public Review): A Plasmodium falciparum MORC protein complex modulates epigenetic control of gene expression through interaction with heterochromatin Open
Dynamic control of gene expression is critical for blood stage development of malaria parasites. Here, we used multi-omic analyses to investigate transcriptional regulation by the chromatin-associated microrchidia protein, MORC, during ase…
View article: A Plasmodium falciparum MORC protein complex modulates epigenetic control of gene expression through interaction with heterochromatin
A Plasmodium falciparum MORC protein complex modulates epigenetic control of gene expression through interaction with heterochromatin Open
Dynamic control of gene expression is critical for blood stage development of malaria parasites. Here, we used multi-omic analyses to investigate transcriptional regulation by the chromatin-associated microrchidia protein, MORC, during ase…
View article: Plasmodium falciparum MORC protein modulates gene expression through interaction with heterochromatin
Plasmodium falciparum MORC protein modulates gene expression through interaction with heterochromatin Open
Dynamic control of gene expression is critical for blood stage development of malaria parasites. Here, we used multi-omic analyses to investigate transcriptional regulation by the chromatin-associated microrchidia protein, MORC, during ase…
View article: Reviewer #2 (Public Review): Plasmodium falciparum MORC protein modulates gene expression through interaction with heterochromatin
Reviewer #2 (Public Review): Plasmodium falciparum MORC protein modulates gene expression through interaction with heterochromatin Open
Dynamic control of gene expression is critical for blood stage development of malaria parasites. Here, we used multi-omic analyses to investigate transcriptional regulation by the chromatin-associated microrchidia protein, MORC, during ase…
View article: A Plasmodium falciparum MORC protein complex modulates epigenetic control of gene expression through interaction with heterochromatin
A Plasmodium falciparum MORC protein complex modulates epigenetic control of gene expression through interaction with heterochromatin Open
Dynamic control of gene expression is critical for blood stage development of malaria parasites. Here, we used multi-omic analyses to investigate transcriptional regulation by the chromatin-associated microrchidia protein, MORC, during ase…
View article: Reviewer #1 (Public Review): Plasmodium falciparum MORC protein modulates gene expression through interaction with heterochromatin
Reviewer #1 (Public Review): Plasmodium falciparum MORC protein modulates gene expression through interaction with heterochromatin Open
Dynamic control of gene expression is critical for blood stage development of malaria parasites. Here, we used multi-omic analyses to investigate transcriptional regulation by the chromatin-associated microrchidia protein, MORC, during ase…
View article: Mammalian cells internalize bacteriophages and use them as a resource to enhance cellular growth and survival
Mammalian cells internalize bacteriophages and use them as a resource to enhance cellular growth and survival Open
There is a growing appreciation that the direct interaction between bacteriophages and the mammalian host can facilitate diverse and unexplored symbioses. Yet the impact these bacteriophages may have on mammalian cellular and immunological…
View article: A <i>Plasmodium falciparum</i> MORC protein complex modulates epigenetic control of gene expression through interaction with heterochromatin
A <i>Plasmodium falciparum</i> MORC protein complex modulates epigenetic control of gene expression through interaction with heterochromatin Open
Dynamic control of gene expression is critical for blood stage development of malaria parasites. Here, we used multi-omic analyses to investigate transcriptional regulation by the chromatin-associated microrchidia protein, MORC, during ase…
View article: Mammalian cells internalize bacteriophages and utilize them as a food source to enhance cellular growth and survival
Mammalian cells internalize bacteriophages and utilize them as a food source to enhance cellular growth and survival Open
There is a growing appreciation that the direct interaction between bacteriophages and the mammalian host can facilitate diverse and unexplored symbioses. Yet the impact these bacteriophages may have on mammalian cellular and immunological…
View article: Parasite and host kinases as targets for antimalarials
Parasite and host kinases as targets for antimalarials Open
We propose priority research areas, including (i) diversification of Plasmodium kinase targets (at present most efforts focus on a very small number of targets); (ii) polypharmacology as an avenue to limit resistance (kinase inhibitors are…
View article: Repurposing of a human antibody-based microarray to explore conserved components of the signalome of the parasitic nematode Haemonchus contortus
Repurposing of a human antibody-based microarray to explore conserved components of the signalome of the parasitic nematode Haemonchus contortus Open
Background Gaining insight into molecular signalling pathways of socioeconomically important parasitic nematodes has implications for understanding their molecular biology and for developing novel anthelmintic interventions. Methods Here, …
View article: Comparative analysis of the kinomes of Plasmodium falciparum, Plasmodium vivax and their host Homo sapiens
Comparative analysis of the kinomes of Plasmodium falciparum, Plasmodium vivax and their host Homo sapiens Open
Background Novel antimalarials should be effective across all species of malaria parasites that infect humans, especially the two species that bear the most impact, Plasmodium falciparum and Plasmodium vivax . Protein kinases encoded by pa…
View article: Additional file 1 of Comparative analysis of the kinomes of Plasmodium falciparum, Plasmodium vivax and their host Homo sapiens
Additional file 1 of Comparative analysis of the kinomes of Plasmodium falciparum, Plasmodium vivax and their host Homo sapiens Open
Additional file 1: Supplementary data 1. HMM of the protein kinase family/group assignment for each of the typical protein kinases investigated here. The protein kinase family/group HMM profiles were acquired from the Kinomer database [29]…
View article: Additional file 5 of Repurposing of a human antibody-based microarray to explore conserved components of the signalome of the parasitic nematode Haemonchus contortus
Additional file 5 of Repurposing of a human antibody-based microarray to explore conserved components of the signalome of the parasitic nematode Haemonchus contortus Open
Additional file 5: Table S4. Chemicals in KinaseSARfari database associated with the detected Haemonchus contortus proteins in the present study
View article: Additional file 3 of Comparative analysis of the kinomes of Plasmodium falciparum, Plasmodium vivax and their host Homo sapiens
Additional file 3 of Comparative analysis of the kinomes of Plasmodium falciparum, Plasmodium vivax and their host Homo sapiens Open
Additional file 3: Supplementary data 3. Alignment of the protein kinase domains of diverse subset of NEKs across 11 different species. This alignment was used to generate a HMM profile for this family used in this study.
View article: Additional file 2 of Repurposing of a human antibody-based microarray to explore conserved components of the signalome of the parasitic nematode Haemonchus contortus
Additional file 2 of Repurposing of a human antibody-based microarray to explore conserved components of the signalome of the parasitic nematode Haemonchus contortus Open
Additional file 2: Table S2. Complete list of signals recorded as being higher in the larval stage (L3) of Haemonchus contortus than in the adult stage—in the Kinexus antibody microarray experiment.
View article: Additional file 1 of Repurposing of a human antibody-based microarray to explore conserved components of the signalome of the parasitic nematode Haemonchus contortus
Additional file 1 of Repurposing of a human antibody-based microarray to explore conserved components of the signalome of the parasitic nematode Haemonchus contortus Open
Additional file 1: Table S1. Complete list of signals recorded as being higher in the adult stage of Haemonchus contortus than in the larval stage (L3)—in the Kinexus antibody microarray experiment.
View article: Additional file 4 of Comparative analysis of the kinomes of Plasmodium falciparum, Plasmodium vivax and their host Homo sapiens
Additional file 4 of Comparative analysis of the kinomes of Plasmodium falciparum, Plasmodium vivax and their host Homo sapiens Open
Additional file 4: Supplementary data 4. Complete Multiple sequence alignment for the typical protein kinases of Homo sapiens, Plasmodium falciparum and Plasmodium vivax. Each sequence is aligned into the 17 highly conserved regions of the…
View article: Additional file 4 of Repurposing of a human antibody-based microarray to explore conserved components of the signalome of the parasitic nematode Haemonchus contortus
Additional file 4 of Repurposing of a human antibody-based microarray to explore conserved components of the signalome of the parasitic nematode Haemonchus contortus Open
Additional file 4: Table S3. Chemicals in the DrugBank database associated with the detected Haemonchus contortus proteins in the present study
View article: Additional file 2 of Comparative analysis of the kinomes of Plasmodium falciparum, Plasmodium vivax and their host Homo sapiens
Additional file 2 of Comparative analysis of the kinomes of Plasmodium falciparum, Plasmodium vivax and their host Homo sapiens Open
Additional file 2: Supplementary data 2. Full table of protein kinase homology comparison between the Plasmodium species of this study and Homo sapiens, using the RAxML bootstrapping support values.
View article: Comparative Analysis of The Kinomes of Plasmodium Falciparum, Plasmodium Vivax And Their Host Homo Sapiens
Comparative Analysis of The Kinomes of Plasmodium Falciparum, Plasmodium Vivax And Their Host Homo Sapiens Open
Background: Novel antimalarials should be effective across all species of malaria parasites that infect humans, especially the two species that bear the most impact, Plasmodium falciparum and Plasmodium vivax . Protein kinases encoded by p…
View article: Host-directed therapy, an untapped opportunity for antimalarial intervention
Host-directed therapy, an untapped opportunity for antimalarial intervention Open
Host-directed therapy (HDT) is gaining traction as a strategy to combat infectious diseases caused by viruses and intracellular bacteria, but its implementation in the context of parasitic diseases has received less attention. Here, we pro…
View article: MAPPINGS v1.0, a tool for network analysis of large phospho-signalling datasets: application to host erythrocyte response to Plasmodium infection
MAPPINGS v1.0, a tool for network analysis of large phospho-signalling datasets: application to host erythrocyte response to Plasmodium infection Open
Phosphorylation-based signalling implicates a complex and intertwined series of pathways and is critical to all domains of life. The interconnectivity between pathways results in the emergence of complex networks whose elucidation present …
View article: Network analysis of large phospho-signalling datasets: application to Plasmodium-erythrocyte interactions
Network analysis of large phospho-signalling datasets: application to Plasmodium-erythrocyte interactions Open
Phosphorylation based signalling is a complicated and intertwined series of pathways critical to all domains of life. This interconnectivity, though essential to life, makes understanding and decoding the interactions difficult. Large data…