Jack A. Gilbert
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Eight-year prevalence and incidence of obesity, high blood glucose and high blood pressure in five African-origin populations: data from the Modeling the Epidemiologic Transition Study Open
Introduction Obesity, high blood glucose and high blood pressure are major drivers of global morbidity. Characterising temporal trends in these conditions among people of African origin can direct public health efforts. This longitudinal c…
View article: Principles for Rigorous Design and Application of Synthetic Microbial Communities
Principles for Rigorous Design and Application of Synthetic Microbial Communities Open
Synthetic microbial communities (SynComs) are microbial consortia with defined taxonomic and functional traits, so that the combination elicits a predictable response under defined conditions. SynComs are artificially designed to enable in…
View article: Longitudinal changes in gut microbiota across reproductive states in wild baboons
Longitudinal changes in gut microbiota across reproductive states in wild baboons Open
Background In humans and other mammals, female reproduction is linked to extensive changes in physiology, immunity, hormones, and behavior. These changes likely shape, and may be shaped by, the composition of gut microbial communities. Cha…
View article: Microbes without borders: uniting societies for climate action
Microbes without borders: uniting societies for climate action Open
The climate crisis is one of the greatest challenges of our time, yet the role of microorganisms remains underrecognised in climate science and policy. Microbes are highly sensitive to environmental change and regulate essential biogeochem…
View article: Microbes without borders: uniting societies for climate action
Microbes without borders: uniting societies for climate action Open
The climate crisis is one of the greatest challenges of our time, yet the role of microorganisms remains underrecognized in climate science and policy. Microbes are highly sensitive to environmental change and regulate essential biogeochem…
View article: Precision Prevention, Diagnostics, and Treatment of Obesity: Pipedream or Reality?
Precision Prevention, Diagnostics, and Treatment of Obesity: Pipedream or Reality? Open
Precision medicine approaches have gained attention for their potential to more effectively manage obesity by tailoring diagnosis and treatment strategies to individual characteristics, including genetic background, phenotypes, metabolic p…
View article: Current state of microbiota clinical applications in neonatal and pediatric bacterial infections
Current state of microbiota clinical applications in neonatal and pediatric bacterial infections Open
The microbiota plays a crucial role in pediatric health by shaping immune development and influencing infection susceptibility. In infants and children, an immature microbiota may compromise immune defense, increasing the risk of bacterial…
View article: SynCom‐mediated herbicide degradation activates microbial carbon metabolism in soils
SynCom‐mediated herbicide degradation activates microbial carbon metabolism in soils Open
Extensive herbicide residues in the black soil of northeastern China are considered a significant agricultural pollution threat, yet effective bioremediation of this complex and persistent mixture remains a challenge. We identified 16 bact…
The microbiota vault initiative: safeguarding Earth’s microbial heritage for future generations Open
Microbial ecosystems are fundamental to planetary and human health, yet human activities are accelerating their loss. Disruptions to microbial communities undermine environmental stability, biodiversity, and health. Urgent action is requir…
View article: Aspartate Is A Determinant of TNF‐α Biogenesis in Sub‐Saharan Africa: Insight Into the Pathogenesis of Noncommunicable Diseases
Aspartate Is A Determinant of TNF‐α Biogenesis in Sub‐Saharan Africa: Insight Into the Pathogenesis of Noncommunicable Diseases Open
Urbanization in sub‐Saharan Africa is characterized by a shift toward a proinflammatory state and rising rates of noncommunicable diseases. The biological mechanism(s) linking changes in environmental factors to health and disease are inco…
View article: Genomic description of <i>Microbacterium mcarthurae</i> sp. nov., a bacterium collected from the International Space Station that exhibits unique antimicrobial-resistant and virulent phenotype
Genomic description of <i>Microbacterium mcarthurae</i> sp. nov., a bacterium collected from the International Space Station that exhibits unique antimicrobial-resistant and virulent phenotype Open
A novel bacterial strain, designated as 1F8SW-P5 T , was isolated from the wall of the crew quarters on the International Space Station. Cells were Gram-staining-positive, strictly aerobic, non-spore-forming, chemoheterotrophic, and mesoph…
Oncogene SETDB1’s Dual Role in Endometrial Cancer: Driving Tumor Progression and Immune Escape Open
Oncogene SETDB1, an H3K9 methyltransferase, drives tumorigenesis in various cancers. Using endometrial cancer (EC) as a model, we discovered SETDB1’s dual mechanisms in driving EC tumorigenesis and mediating immune evasion. SETDB1 knockout…
View article: Toxic metals impact gut microbiota and metabolic risk in five African-origin populations
Toxic metals impact gut microbiota and metabolic risk in five African-origin populations Open
Underlying mechanisms by which exposures to toxic metals/metalloids impact obesity and type 2 diabetes (T2DM) risk remain largely unknown. Gut microbiota have been strongly associated with cardiometabolic risk. To assess relationships betw…
Examining the potential prebiotic effect of almonds Open
Almonds, a nutrient-dense food rich in dietary fiber, polyphenols, and unsaturated fatty acids, exhibit significant potential as a functional food with prebiotic effects. Prebiotics selectively stimulate the growth and activity of benefici…
View article: Social and environmental predictors of gut microbiome age in wild baboons
Social and environmental predictors of gut microbiome age in wild baboons Open
Mammalian gut microbiomes are highly dynamic communities that shape and are shaped by host aging, including age-related changes to host immunity, metabolism, and behavior. As such, gut microbial composition may provide valuable information…
View article: Utility of a quantitative approach to microbial dysbiosis using machine learning in an African American cohort with self-reported hair loss
Utility of a quantitative approach to microbial dysbiosis using machine learning in an African American cohort with self-reported hair loss Open
Microbial dysbiosis has been identified as a therapeutic target for several dermatologic conditions. However, the concept of dysbiosis is poorly defined, limiting reproducibility. We developed a reproducible metric for dysbiosis that can b…
View article: Social and environmental predictors of gut microbiome age in wild baboons
Social and environmental predictors of gut microbiome age in wild baboons Open
Mammalian gut microbiomes are highly dynamic communities that shape and are shaped by host aging, including age-related changes to host immunity, metabolism, and behavior. As such, gut microbial composition may provide valuable information…
Effects of temperature and nutrient load on the interaction of Vibrio parahaemolyticus and plastic pollution in the marine environment Open
Plastic pollution in the marine environment harbors a diverse community of microorganisms called the plastisphere. The plastisphere has been found to contain potential pathogenic species of concern to both marine organisms and human health…