Jack Ao
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View article: Why take the eye? A systematic review of corneal retrieval methods and donor consent: implications for the UK
Why take the eye? A systematic review of corneal retrieval methods and donor consent: implications for the UK Open
Aim To evaluate the effect of the corneal retrieval method on three outcome domains: donor consent rate, tissue quality and microbial contamination. Methods A systematic literature review was conducted using the Scopus, PubMed and Web of S…
View article: Cone photoreceptor preservation with laser photobiomodulation in murine and human retinal dystrophy
Cone photoreceptor preservation with laser photobiomodulation in murine and human retinal dystrophy Open
We used a novel slit lamp-delivered photobiomodulation (PBM) retinal laser to preserve cone photoreceptors in an animal model of retinitis pigmentosa (RP) and to improve visual acuity in individuals with advanced RP. RP refers to a genetic…
View article: Cone Rescue with Laser Photobiomodulation in Murine and Human Retinal Dystrophy
Cone Rescue with Laser Photobiomodulation in Murine and Human Retinal Dystrophy Open
Retinitis pigmentosa (RP) encompasses a genetically diverse group of blinding inherited retinal diseases. In most subtypes the gene defect is expressed in the rod photoreceptors, yet in many affected individuals the cone photoreceptors und…
View article: Safety Profile of Slit-Lamp-Delivered Retinal Laser Photobiomodulation
Safety Profile of Slit-Lamp-Delivered Retinal Laser Photobiomodulation Open
This study provides important data necessary for clinical translation of laser-delivered PBM for retinal diseases.
View article: Spatio-temporal characterization of S- and M/L-cone degeneration in the Rd1 mouse model of retinitis pigmentosa
Spatio-temporal characterization of S- and M/L-cone degeneration in the Rd1 mouse model of retinitis pigmentosa Open
Background The Pde6brd1 (Rd1) mouse is widely used as a murine model for human retinitis pigmentosa. Understanding the spatio-temporal patterns of cone degeneration is important for evaluating potential treatments. In the present study we …
View article: Spatio-temporal characterization of S- and M/L-cone degeneration in the Rd1 mouse model of retinitis pigmentosa
Spatio-temporal characterization of S- and M/L-cone degeneration in the Rd1 mouse model of retinitis pigmentosa Open
Background The Pde6brd1 (Rd1) mouse is widely used as a murine model for human retinitis pigmentosa. Understanding the spatio-temporal patterns of cone degeneration is important for evaluating potential treatments. In the present study we …
View article: Spatio-temporal characterization of S- and M/L-cone degeneration in the Rd1 mouse model of retinitis pigmentosa
Spatio-temporal characterization of S- and M/L-cone degeneration in the Rd1 mouse model of retinitis pigmentosa Open
Background The Pde6brd1 (Rd1) mouse is widely used as a murine model for human retinitis pigmentosa. Understanding the spatio-temporal patterns of cone degeneration is important for evaluating potential treatments. In the present study we …
View article: Retinal pigment epithelium in the pathogenesis of age‐related macular degeneration and photobiomodulation as a potential therapy?
Retinal pigment epithelium in the pathogenesis of age‐related macular degeneration and photobiomodulation as a potential therapy? Open
The retinal pigment epithelium (RPE) comprises a monolayer of cells located between the neuroretina and the choriocapillaries. The RPE serves several important functions in the eye: formation of the blood‐retinal barrier, protection of the…
View article: Review of the ophthalmic manifestations of gout and uric acid crystal deposition
Review of the ophthalmic manifestations of gout and uric acid crystal deposition Open
Gout is a clinical disorder that is characterized by the deposition of monosodium urate crystals (MSU) in joints and tendons, usually in the presence of prolonged hyperuricaemia. Following an asymptomatic phase of hyperuricaemia, gout usua…