Jack Barrett
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View article: Insulin-Mediated Growth in Aortic Smooth Muscle and the Vascular Renin-Angiotensin System
Insulin-Mediated Growth in Aortic Smooth Muscle and the Vascular Renin-Angiotensin System Open
—Insulin has been shown to directly affect blood vessel tone and to promote vascular hypertrophy, but the mechanism of these actions remains uncertain. Because angiotensin I (Ang I)–converting enzyme inhibitors have been shown to improve i…
View article: Nuclear angiotensin receptors induce transcription of renin and angiotensinogen mRNA.
Nuclear angiotensin receptors induce transcription of renin and angiotensinogen mRNA. Open
The observation that nuclei from hepatic tissue exhibit specific angiotensin II (Ang II) binding led us to explore whether Ang II modulates mRNA in general, mRNA specific for renin system components, or both. Nuclei from hepatic tissue exh…
View article: Production of angiotensinogen and renin-like activity by rabbit proximal tubular cells in culture
Production of angiotensinogen and renin-like activity by rabbit proximal tubular cells in culture Open
View article: In vivo and in vitro alterations of active and inactive plasma renins in the rat.
In vivo and in vitro alterations of active and inactive plasma renins in the rat. Open
The levels of active, inactive, and total renin (trypsin treatment) were measured in rat plasma before and after in vivo stimulation or suppression of active plasma renin. Stimulation of active renin was accompanied by either an increase (…
View article: Coupling of β-Adrenoreceptors in Rat Uterine Smooth Muscle
Coupling of β-Adrenoreceptors in Rat Uterine Smooth Muscle Open
The role of myometrial β-adrenoreceptors (characterized by specific binding of (-)-[3H]-dihydroalprenolol) in the control of uterine relaxation and cAMP production was investigated by determining the concentrations of isoproterenol which p…
View article: Activation of Rat Plasma Renin*
Activation of Rat Plasma Renin* Open
Three distinct molecular weight species of active renin, with apparent molecular weights of more than 150,000, 65,000, and 43,000 are present in the plasma of conscious rats. After acute in vivo renin stimulation (ether anesthesia and hemo…
View article: Studies on angiotensinogen of plasma and cerebrospinal fluid in normal and hypertensive human subjects.
Studies on angiotensinogen of plasma and cerebrospinal fluid in normal and hypertensive human subjects. Open
The presence of a renin-angiotensin system in the central nervous system (CNS) has been demonstrated by several investigators, but little is known regarding the origin of its components. In this study we have compared the immunological and…
View article: Angiotensin II, plasma renin and sodium depletion as determinants of blood pressure response to saralasin in essential hypertension.
Angiotensin II, plasma renin and sodium depletion as determinants of blood pressure response to saralasin in essential hypertension. Open
To evaluate the role of the renin-angiotensin system and sodium depletion in the hypotensive response to 1-sarcosine-8-alanine-angiotensin II (saralasin), 15 male patients with essential hypertension were studied on a diet containing 120 m…
View article: Studies on renin activation in normal human plasma.
Studies on renin activation in normal human plasma. Open
The phenomenon of plasma renin activattion by acid dialysis and preincubation with trypsin was studied in normal human plasma. Activation of plasma renin by exposure to pH 3.3 was shown to require at least one dialysis step and could be in…
View article: Multiple forms of human plasma renin substrate.
Multiple forms of human plasma renin substrate. Open
The objective of this investigation was to determine whether heterogeneity of plasma renin substrate could be observed in states of steroid excess and various forms of hypertensive disease. In states of stimulated renin substrate productio…
View article: "Big big renin*. Enzymatic and partial physical characterization of a new high molecular weight renin from normal human kidney.
"Big big renin*. Enzymatic and partial physical characterization of a new high molecular weight renin from normal human kidney. Open
View article: Development of Tachyphylaxis to Aspartyl <sup>1</sup> and Not to Asparginyl <sup>1</sup> Angiotensin II in the Rat
Development of Tachyphylaxis to Aspartyl <sup>1</sup> and Not to Asparginyl <sup>1</sup> Angiotensin II in the Rat Open
Pressor responses to single increasing doses (0.001 to 10 µg) and constant infusions (0.01 to 5 mg/kg per hr) of synthetic aspartyl 1 angiotensin II (Asp 1 ) and asparginyl 1 angiotensin II (Aspg 1 , Hypertensin, CIBA) were measured in nor…