Jack Bevers
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View article: Combined antagonism of Oncostatin M (OSM) and Interleukin 6 (IL-6) provides both anti-fibrotic and anti-inflammatory benefit in pulmonary fibrosis
Combined antagonism of Oncostatin M (OSM) and Interleukin 6 (IL-6) provides both anti-fibrotic and anti-inflammatory benefit in pulmonary fibrosis Open
Interstitial lung diseases (ILDs), including idiopathic pulmonary fibrosis (IPF) and systemic sclerosis-associated ILD (SSc-ILD), are irreversible fibrosing diseases with a mean survival time of less than 5 years for IPF. Poorly understood…
View article: Property Enhancer – a data efficient multi-objective approach for functional antibody optimization
Property Enhancer – a data efficient multi-objective approach for functional antibody optimization Open
In-silico antibody lead optimization remains challenging due to scarce high-quality data, costly experimental validation, and the need to jointly optimize multiple developability properties. Discovery workflows often rely on high-throughpu…
View article: Lab-in-the-loop therapeutic antibody design with deep learning
Lab-in-the-loop therapeutic antibody design with deep learning Open
Therapeutic antibody design is a complex multi-property optimization problem with substantial promise for improvement with the application of machine-learning methods. Towards realizing that promise, we introduce “Lab-in-the-loop,” a new a…
View article: AviTrap: A novel solution to achieve complete biotinylation
AviTrap: A novel solution to achieve complete biotinylation Open
Site specific biotinylation of AviTagged recombinant proteins using BirA enzyme is a widely used protein labeling technology. However, due to the incomplete biotinylation reactions and the lack of a purification method specific for the bio…
View article: An agonistic anti-signal regulatory protein α antibody for chronic inflammatory diseases
An agonistic anti-signal regulatory protein α antibody for chronic inflammatory diseases Open
Signal regulatory protein (SIRPα) is an immune inhibitory receptor expressed by myeloid cells to inhibit immune cell phagocytosis, migration, and activation. Despite the progress of SIRPα and CD47 antagonist antibodies to promote anti-canc…
View article: Antibody homotypic interactions are encoded by germline light chain complementarity determining region 2
Antibody homotypic interactions are encoded by germline light chain complementarity determining region 2 Open
Significance Weak transient interactions are fundamental to immune responses, enabling avidity-driven triggers for pathogen neutralization and cellular regulation. In contrast to obligate binding interactions that can be directly investiga…
View article: MICA immune complex formed with alpha 3 domain-specific antibody activates human NK cells in a Fc-dependent manner
MICA immune complex formed with alpha 3 domain-specific antibody activates human NK cells in a Fc-dependent manner Open
Our results demonstrate that an α3 domain-specific MICA antibody can circumvent sMICA-mediated suppression of NK cell cytolytic activity. Moreover, our data suggest that MICA immune complexes formed with α3-specific antibodies can activate…
View article: Massive antibody discovery used to probe structure–function relationships of the essential outer membrane protein LptD
Massive antibody discovery used to probe structure–function relationships of the essential outer membrane protein LptD Open
Outer membrane proteins (OMPs) in Gram-negative bacteria dictate permeability of metabolites, antibiotics, and toxins. Elucidating the structure-function relationships governing OMPs within native membrane environments remains challenging.…
View article: Author response: Massive antibody discovery used to probe structure–function relationships of the essential outer membrane protein LptD
Author response: Massive antibody discovery used to probe structure–function relationships of the essential outer membrane protein LptD Open
Article Figures and data Abstract eLife digest Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Outer membrane proteins (OMPs…
View article: High-resolution glycosylation site-engineering method identifies MICA epitope critical for shedding inhibition activity of anti-MICA antibodies.
High-resolution glycosylation site-engineering method identifies MICA epitope critical for shedding inhibition activity of anti-MICA antibodies. Open
As an immune evasion strategy, MICA and MICB, the major histocompatibility complex class I homologs, are proteolytically cleaved from the surface of cancer cells leading to impairment of CD8 + T cell- and natural killer cell-mediated immun…
View article: High-resolution glycosylation site-engineering method identifies MICA epitope critical for shedding inhibition activity of anti-MICA antibodies
High-resolution glycosylation site-engineering method identifies MICA epitope critical for shedding inhibition activity of anti-MICA antibodies Open
As an immune evasion strategy, MICA and MICB, the major histocompatibility complex class I homologs, are proteolytically cleaved from the surface of cancer cells leading to impairment of CD8 + T cell- and natural killer cell-mediated immun…