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View article: Theoretical and practical considerations for validating antigen-specific B cell ImmunoSpot assays
Theoretical and practical considerations for validating antigen-specific B cell ImmunoSpot assays Open
Owing to their ability to reliably detect even very rare antigen-specific B cells in cellular isolates such as peripheral blood mononuclear cells (PBMC), and doing so robustly in a high throughput-compatible manner, B cell ELISPOT/FluoroSp…
View article: Theoretical and practical considerations for validating antigen-specific B cell ImmunoSpot assays
Theoretical and practical considerations for validating antigen-specific B cell ImmunoSpot assays Open
Owing to their ability to reliably detect even very rare antigen-specific B cells in cellular isolates such as peripheral blood mononuclear cells (PBMC), and doing so robustly in a high throughput-compatible manner, B cell ELISPOT/FluoroSp…
View article: Four-Color ImmunoSpot® Assays Requiring Only 1–3 mL of Blood Permit Precise Frequency Measurements of Antigen-Specific B Cells-Secreting Immunoglobulins of All Four Classes and Subclasses
Four-Color ImmunoSpot® Assays Requiring Only 1–3 mL of Blood Permit Precise Frequency Measurements of Antigen-Specific B Cells-Secreting Immunoglobulins of All Four Classes and Subclasses Open
The B lymphocyte response can encompass four immunoglobulin (Ig) classes and four IgG subclasses, each contributing fundamentally different effector functions. Production of the appropriate Ig class/subclass is critical for both successful…
View article: Assessing the Affinity Spectrum of the Antigen-Specific B Cell Repertoire via ImmunoSpot®
Assessing the Affinity Spectrum of the Antigen-Specific B Cell Repertoire via ImmunoSpot® Open
The affinity distribution of the antigen-specific memory B cell (B mem ) repertoire in the body is a critical variable that defines an individual’s ability to rapidly generate high-affinity protective antibody specificities. Detailed measu…
View article: Assessing the affinity spectrum of the antigen-specific B cell repertoire via ImmunoSpot®
Assessing the affinity spectrum of the antigen-specific B cell repertoire via ImmunoSpot® Open
The affinity distribution of the antigen-specific memory B cell (B mem ) repertoire in the body is a critical variable that defines an individual’s ability to rapidly generate high affinity protective antibody specificities. Detailed measu…
View article: Assessing the affinity spectrum of the antigen-specific B cell repertoire via ImmunoSpot®
Assessing the affinity spectrum of the antigen-specific B cell repertoire via ImmunoSpot® Open
The affinity distribution of the antigen-specific memory B cell (B mem ) repertoire in the body is a critical variable that defines an individual’s ability to rapidly generate high affinity protective antibody specificities. Detailed measu…