Jack C. Yu
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View article: Rethinking Alzheimer's: Harnessing Cannabidiol to Modulate IDO and cGAS Pathways for Neuroinflammation Control
Rethinking Alzheimer's: Harnessing Cannabidiol to Modulate IDO and cGAS Pathways for Neuroinflammation Control Open
Alzheimer's disease (AD) has traditionally been associated with amyloid-β plaques, but growing evidence underscores the role of neuroinflammation in disease progression. The autoinflammatory hypothesis of AD suggests chronic immune dysfunc…
View article: Protective Role of CBD Against Nicotine Pouch–Induced Seizure Aggravation and Alterations in Brain Glymphatic Biomarkers
Protective Role of CBD Against Nicotine Pouch–Induced Seizure Aggravation and Alterations in Brain Glymphatic Biomarkers Open
Nicotine pouches are increasingly popular as a smokeless alternative to tobacco, yet their long-term neurological effects remain poorly understood. In this preclinical study, we investigated the time-dependent impact of oral nicotine pouch…
View article: Rethinking Alzheimer’s: Harnessing Cannabidiol to Modulate IDO and cGAS Pathways for Neuroinflammation Control
Rethinking Alzheimer’s: Harnessing Cannabidiol to Modulate IDO and cGAS Pathways for Neuroinflammation Control Open
Alzheimer’s disease has traditionally been associated with amyloid-β plaques, but growing evidence underscores the role of neuroinflammation in disease progression. The autoimmune hypothesis of Alzheimer’s disease suggests chronic inflamma…
View article: Optimization of seizure prevention by cannabidiol (CBD)
Optimization of seizure prevention by cannabidiol (CBD) Open
Objective Cannabidiol (CBD) is one of the most prominent non-psychotropic cannabinoids with known therapeutic potentials. Based on its anti-seizure efficacy, the first cannabis derived pharmaceutical grade CBD-based medication was approved…
View article: Fixing the Perspective: A Critical Examination of Zero-1-to-3
Fixing the Perspective: A Critical Examination of Zero-1-to-3 Open
Novel view synthesis is a fundamental challenge in image-to-3D generation, requiring the generation of target view images from a set of conditioning images and their relative poses. While recent approaches like Zero-1-to-3 have demonstrate…
View article: Suppression of SIGMAR1 hinders oral cancer cell growth via modulation of mitochondrial Ca2+ dynamics
Suppression of SIGMAR1 hinders oral cancer cell growth via modulation of mitochondrial Ca2+ dynamics Open
Oral cancer is the most common malignancy of the oral cavity and facial region, affecting the mucosal and epithelial surfaces in the mouth and lips. Unfortunately, OC is often associated with a high mortality rate and limited treatment opt…
View article: Boosting Acetylcholine Signaling by Cannabidiol in a Murine Model of Alzheimer’s Disease
Boosting Acetylcholine Signaling by Cannabidiol in a Murine Model of Alzheimer’s Disease Open
Alzheimer’s disease (AD) is a challenging medical issue that requires efficacious treatment options to improve long-term quality of life. Cannabidiol (CBD) is a cannabis-derived phytocannabinoid with potential health benefits, including re…
View article: Optimization of Seizure Prevention by Cannabidiol (CBD)
Optimization of Seizure Prevention by Cannabidiol (CBD) Open
Objective Cannabidiol (CBD) is one of the most prominent non-psychotropic cannabinoids with known therapeutic potentials. Based on its anti-seizure efficacy, the first cannabis derived, pharmaceutical grade CBD-based medication was approve…
View article: Cutaneous Wound Healing and the Effects of Cannabidiol
Cutaneous Wound Healing and the Effects of Cannabidiol Open
Cutaneous wounds, both acute and chronic, begin with loss of the integrity, and thus barrier function, of the skin. Surgery and trauma produce acute wounds. There are 22 million surgical procedures per year in the United States alone, base…
View article: The synergy between cannabidiol and probiotics curtails the glycemic indicators, enhances insulin production, and alleviates the symptoms of type 2 diabetes
The synergy between cannabidiol and probiotics curtails the glycemic indicators, enhances insulin production, and alleviates the symptoms of type 2 diabetes Open
Diabetes continues to challenge healthcare system as one of the most growing epidemics with staggering economic burden. It is estimated that 783 million by 2045 will live with diabetes worldwide, 90% of those cases are type 2 diabetes (T2D…
View article: Supplementary Figure 2 from Subtypes of Breast Cancer Show Preferential Site of Relapse
Supplementary Figure 2 from Subtypes of Breast Cancer Show Preferential Site of Relapse Open
Supplementary Figure 2 from Subtypes of Breast Cancer Show Preferential Site of Relapse
View article: Supplementary Information from Gene Expression Signatures for Predicting Prognosis of Squamous Cell and Adenocarcinomas of the Lung
Supplementary Information from Gene Expression Signatures for Predicting Prognosis of Squamous Cell and Adenocarcinomas of the Lung Open
Information, Tables 1-5, Figures 1-5
View article: Supplementary Figure 3 from Subtypes of Breast Cancer Show Preferential Site of Relapse
Supplementary Figure 3 from Subtypes of Breast Cancer Show Preferential Site of Relapse Open
Supplementary Figure 3 from Subtypes of Breast Cancer Show Preferential Site of Relapse
View article: Supplementary Figure 3 from Subtypes of Breast Cancer Show Preferential Site of Relapse
Supplementary Figure 3 from Subtypes of Breast Cancer Show Preferential Site of Relapse Open
Supplementary Figure 3 from Subtypes of Breast Cancer Show Preferential Site of Relapse
View article: Supplementary Figure 2 from Subtypes of Breast Cancer Show Preferential Site of Relapse
Supplementary Figure 2 from Subtypes of Breast Cancer Show Preferential Site of Relapse Open
Supplementary Figure 2 from Subtypes of Breast Cancer Show Preferential Site of Relapse
View article: Supplementary Figure 1 from Subtypes of Breast Cancer Show Preferential Site of Relapse
Supplementary Figure 1 from Subtypes of Breast Cancer Show Preferential Site of Relapse Open
Supplementary Figure 1 from Subtypes of Breast Cancer Show Preferential Site of Relapse
View article: Data from Gene Expression Signatures for Predicting Prognosis of Squamous Cell and Adenocarcinomas of the Lung
Data from Gene Expression Signatures for Predicting Prognosis of Squamous Cell and Adenocarcinomas of the Lung Open
Non–small-cell lung cancers (NSCLC) compose 80% of all lung carcinomas with squamous cell carcinomas (SCC) and adenocarcinoma representing the majority of these tumors. Although patients with early-stage NSCLC typically have a better outco…
View article: Data from Subtypes of Breast Cancer Show Preferential Site of Relapse
Data from Subtypes of Breast Cancer Show Preferential Site of Relapse Open
We explored whether the five previously reported molecular subtypes in breast cancer show a preference for organ-specific relapse and searched for molecular pathways involved. The “intrinsic” gene list describing the subtypes was used to c…
View article: Supplementary Information from Gene Expression Signatures for Predicting Prognosis of Squamous Cell and Adenocarcinomas of the Lung
Supplementary Information from Gene Expression Signatures for Predicting Prognosis of Squamous Cell and Adenocarcinomas of the Lung Open
Information, Tables 1-5, Figures 1-5
View article: Data from Subtypes of Breast Cancer Show Preferential Site of Relapse
Data from Subtypes of Breast Cancer Show Preferential Site of Relapse Open
We explored whether the five previously reported molecular subtypes in breast cancer show a preference for organ-specific relapse and searched for molecular pathways involved. The “intrinsic” gene list describing the subtypes was used to c…
View article: Data from Gene Expression Signatures for Predicting Prognosis of Squamous Cell and Adenocarcinomas of the Lung
Data from Gene Expression Signatures for Predicting Prognosis of Squamous Cell and Adenocarcinomas of the Lung Open
Non–small-cell lung cancers (NSCLC) compose 80% of all lung carcinomas with squamous cell carcinomas (SCC) and adenocarcinoma representing the majority of these tumors. Although patients with early-stage NSCLC typically have a better outco…
View article: Supplementary Figure 1 from Subtypes of Breast Cancer Show Preferential Site of Relapse
Supplementary Figure 1 from Subtypes of Breast Cancer Show Preferential Site of Relapse Open
Supplementary Figure 1 from Subtypes of Breast Cancer Show Preferential Site of Relapse
View article: Principles of care for patients with craniofacial ballistic injuries
Principles of care for patients with craniofacial ballistic injuries Open
The mortality rate from firearm injuries in the United States has decreased from 30.3 per 100,000 people in 1990 to 20.6 in 2010, likely because of improvement in treatments. However, the incidence of gunshot wounds continues to increase, …
View article: Sexual Dimorphism in the Polarization of Cardiac ILCs through Elabela
Sexual Dimorphism in the Polarization of Cardiac ILCs through Elabela Open
Elabela is a component of the apelinergic system and may exert a cardioprotective role by regulating the innate immune responses. Innate lymphoid cells (ILCs) have a significant role in initiating and progressing immune-inflammatory respon…
View article: Inhalant Cannabidiol Inhibits Glioblastoma Progression Through Regulation of Tumor Microenvironment
Inhalant Cannabidiol Inhibits Glioblastoma Progression Through Regulation of Tumor Microenvironment Open
Introduction: Glioblastoma (GBM) is the most common invasive brain tumor composed of diverse cell types with poor prognosis. The highly complex tumor microenvironment (TME) and its interaction with tumor cells play important roles in the d…
View article: A potential role for cannabichromene in modulating TRP channels during acute respiratory distress syndrome
A potential role for cannabichromene in modulating TRP channels during acute respiratory distress syndrome Open
Background Acute respiratory distress syndrome (ARDS) is a life-threatening clinical syndrome whose potential to become one of the most grievous challenges of the healthcare system evidenced by the COVID-19 pandemic. Considering the lack o…
View article: High Levels of Interferon-Alpha Expressing Macrophages in Human Breast Milk During SARS-CoV-2 Infection: A Case Report
High Levels of Interferon-Alpha Expressing Macrophages in Human Breast Milk During SARS-CoV-2 Infection: A Case Report Open
Introduction: In addition to hand washing and wearing masks, social distancing and reducing exposure time to Case Description: With Institutional Review Board (IRB) approval, we obtained expressed breast milk samples from a lactating mothe…