Jack Cotter
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Examining the effect of L-theanine on sleep: a systematic review of dietary supplementation trials Open
Objective: Sleep problems are a common complaint among adults worldwide, however, the use of prescription and over-the-counter products may not always be an appropriate or desirable solution. L-theanine is a naturally occurring, non-protei…
Generating normative data from web-based administration of the Cambridge Neuropsychological Test Automated Battery using a Bayesian framework Open
Introduction Normative cognitive data can distinguish impairment from healthy cognitive function and pathological decline from normal ageing. Traditional methods for deriving normative data typically require extremely large samples of heal…
An exploratory, randomised, crossover study to investigate the effect of nicotine on cognitive function in healthy adult smokers who use an electronic cigarette after a period of smoking abstinence Open
Background As well as being associated with serious negative health outcomes, smoking has been reported to have an array of physiological and psychological effects, including effects on mood and cognitive function. Post-cessation, loss of …
Generating normative data from web-based administration of the Cambridge Neuropsychological Test Automated Battery (CANTAB) using a Bayesian framework (Preprint) Open
BACKGROUND Normative cognitive data can distinguish impairment from healthy cognitive function and pathological decline from normal ageing. Traditional methods for deriving normative data typically require extremely large samples of health…
Feed your microbiome and improve sleep, stress resilience, and cognition Open
The brain and gut are connected both physically and biochemically. The gut-brain axis includes the central nervous system, neuroendocrine and neuroimmune systems, the enteric nervous system and vagus nerve, and the gut microbiome. It can i…
The efficacy and safety of nutrient supplements in the treatment of mental disorders: a meta‐review of meta‐analyses of randomized controlled trials Open
The role of nutrition in mental health is becoming increasingly acknowledged. Along with dietary intake, nutrition can also be obtained from “nutrient supplements”, such as polyunsaturated fatty acids (PUFAs), vitamins, minerals, antioxida…
The Use of Cognitive Screening in Pharmacotherapy Trials for Cognitive Impairment Associated With Schizophrenia Open
There are currently no regulatory approved pharmacological treatments for cognitive impairment associated with schizophrenia (CIAS). One possibility is that trial methodology itself is hindering their development. Emerging evidence suggest…
What Is the Role of Dietary Inflammation in Severe Mental Illness? A Review of Observational and Experimental Findings Open
Severe mental illnesses (SMI), including major depressive disorder, bipolar disorder, and schizophrenia, are associated with increased inflammation. Given diet's role in modulating inflammatory processes, excessive calorie-dense, nutrient-…
32.3 A POST-HOC ANALYSIS EXPLORING PARTICIPANT-LEVEL TRAJECTORIES OF COGNITIVE PERFORMANCE AMONG PATIENTS WITH SCHIZOPHRENIA IN A MULTI-NATIONAL PHASE II TRIAL Open
It remains unclear whether the lack of clinical trial success and drug approval for cognitive impairment associated with schizophrenia (CIAS) is due to compounds being ineffective, or whether trial methodology itself has been a limiting fa…
32.1 PHARMACOTHERAPY TRIALS FOR CIAS: A BRIEF HISTORY AND CONSIDERATIONS FOR THE FUTURE Open
Cognitive impairment is common in people with schizophrenia and is among the strongest predictors of functional decline in this patient group. Despite considerable efforts, there are however no pharmacological treatments for cognitive impa…
Using Affective Cognition to Enhance Precision Psychiatry Open
OPINION article Front. Psychiatry, 29 June 2018Sec. Mood Disorders Volume 9 - 2018 | https://doi.org/10.3389/fpsyt.2018.00288
Investigating Domain-Specific Cognitive Impairment Among Patients With Multiple Sclerosis Using Touchscreen Cognitive Testing in Routine Clinical Care Open
Cognitive dysfunction is present in up to 70% of patients with multiple sclerosis (MS) and has been reported at all stages and in all subtypes of the disease. These deficits have been reported across a variety of cognitive domains, but are…
T79. AFFECTIVE FACE PROCESSING IN SCHIZOPHRENIA: DISORDER-SPECIFIC OR TRANSDIAGNOSTIC DEFICIT? Open
Social cognitive dysfunction is common in patients with schizophrenia and is associated with marked and persistent functional disability. Facial emotion recognition is a core aspect of social cognition and has been consistently demonstrate…
S74. EXPLORING PARTICIPANT-LEVEL TRAJECTORIES OF COGNITIVE PERFORMANCE AMONG PATIENTS WITH SCHIZOPHRENIA IN A MULTI-NATIONAL TRIAL Open
It remains unclear whether the lack of clinical trial success and drug approval for cognitive impairment associated with schizophrenia (CIAS) is due to compounds being ineffective, or whether trial methodology itself has been a limiting fa…
Exploring functional impairment in young people at ultra‐high risk for psychosis: A qualitative study Open
Aim Many young people at ultra‐high risk (UHR) of developing psychosis exhibit marked and persistent impairments in social and occupational functioning. We aimed to explore UHR patients' subjective experiences of these difficulties and the…
Social cognitive dysfunction as a clinical marker: A systematic review of meta-analyses across 30 clinical conditions Open
Social cognition includes a range of cognitive processes that help individuals to understand how others think and feel. There is emerging evidence that social cognitive deficits may represent a transdiagnostic issue, potentially serving as…
Exploring the impact of adverse childhood experiences on symptomatic and functional outcomes in adulthood: advances, limitations and considerations Open
Exposure to traumatic experiences in childhood is a risk (and potentially causal) factor for the development of a range of adverse physical and mental health conditions. In addition to the onset of clinical disorders, there is emerging evi…
The pro‐cognitive mechanisms of physical exercise in people with schizophrenia Open
Schizophrenia is associated with pervasive cognitive deficits which are unresponsive to antipsychotic medications. Physical exercise has been shown to improve cognitive functioning in people with schizophrenia, although the mechanisms for …
View article: Cannabis use and symptom severity in individuals at ultra high risk for psychosis: a meta‐analysis
Cannabis use and symptom severity in individuals at ultra high risk for psychosis: a meta‐analysis Open
Objective We aimed to assess whether individuals at ultra high risk ( UHR ) for psychosis have higher rates of cannabis use and cannabis use disorders ( CUD s) than non‐ UHR individuals and determine whether UHR cannabis users have more se…
Social cognition in multiple sclerosis Open
Social cognitive deficits are an overlooked but potentially important aspect of cognitive impairment in MS with potential prognostic significance for social functioning and quality of life. Further research is required to clarify the longi…
Long‐term maintenance and effects of exercise in early psychosis Open
Aim The aims of this study were to examine if people with first‐episode psychosis ( FEP ) are able to continue adhering to exercise after a supervised intervention and to explore if the benefits of exercise can be sustained. Methods Twenty…
Adulthood revictimization: looking beyond childhood trauma Open
Childhood trauma is a risk factor for a range of psychiatric disorders and other adverse outcomes including impaired social functioning, poor physical health, selfinjurious behaviour and addiction (1).This has important clinical implicatio…
Cardiometabolic risk factors in young people at ultra-high risk for psychosis: A systematic review and meta-analysis Open
UHR samples display cardiometabolic risk factors which are largely modifiable. The UHR phase is an important opportunity for early intervention services to improve physical health.