Jack Dodson
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Effects of polygenic liability for autism on neonatal thalamocortical connectivity and behavioral outcomes across sex Open
Functional brain networks are altered in Autism Spectrum Disorder (ASD), with differences in thalamocortical connectivity detectable as early as infancy. ASD shows distinct sex differences, not only in diagnostic rates, but also in brain a…
Effects of periodic bottlenecks on the dynamics of adaptive evolution in microbial populations Open
Population bottlenecks can impact the rate of adaptation in evolving populations. On the one hand, each bottleneck reduces the genetic variation that fuels adaptation. On the other hand, each founder that survives a bottleneck can undergo …
Splicing-specific transcriptome-wide association uncovers genetic mechanisms for schizophrenia Open
Recent studies have highlighted the essential role of RNA splicing, a key mechanism of alternative RNA processing, in establishing connections between genetic variations and disease. Genetic loci influencing RNA splicing variations show co…
View article: Generalized parton distributions from lattice QCD with asymmetric momentum transfer: Axial-vector case
Generalized parton distributions from lattice QCD with asymmetric momentum transfer: Axial-vector case Open
Recently, we made significant advancements in improving the computational efficiency of lattice QCD calculations for generalized parton distributions (GPDs). This progress was achieved by adopting calculations of matrix elements in asymmet…
View article: Generalized Parton Distributions from Lattice QCD with Asymmetric Momentum Transfer: Axial-vector case
Generalized Parton Distributions from Lattice QCD with Asymmetric Momentum Transfer: Axial-vector case Open
Recently, we made significant advancements in improving the computational efficiency of lattice QCD calculations for Generalized Parton Distributions (GPDs). This progress was achieved by adopting calculations of matrix elements in asymmet…
View article: Chiral-even axial twist-3 GPDs of the proton from lattice QCD
Chiral-even axial twist-3 GPDs of the proton from lattice QCD Open
This work presents the first lattice-QCD calculation of the twist-3 axialquark generalized parton distributions (GPDs) for the proton using the large-momentum effective theory approach. We calculate matrix elements with momentum-boosted pr…
The glutathione import system satisfies the Staphylococcus aureus nutrient sulfur requirement and promotes interspecies competition Open
Sulfur is an indispensable element for bacterial proliferation. Prior studies demonstrated that the human pathogen Staphylococcus aureus utilizes glutathione (GSH) as a source of nutrient sulfur; however, mechanisms of GSH acquisition are …
View article: Chiral-even axial twist-3 GPDs of the proton from lattice QCD
Chiral-even axial twist-3 GPDs of the proton from lattice QCD Open
This work presents the first lattice-QCD calculation of the twist-3 axial quark GPDs for the proton using the large-momentum effective theory approach. We calculate matrix elements with momentum-boosted proton states and a non-local axial …
View article: Generalized Parton Distributions from Lattice QCD
Generalized Parton Distributions from Lattice QCD Open
In recent years, there has been a breakthrough in lattice calculations of $x$-dependent partonic distributions. This encompasses also distributions describing the 3D structure of the nucleon, such as generalized parton distributions (GPDs)…
View article: Supplementary Figures and Tables from Single-Cell Analysis in Lung Adenocarcinoma Implicates RNA Editing in Cancer Innate Immunity and Patient Prognosis
Supplementary Figures and Tables from Single-Cell Analysis in Lung Adenocarcinoma Implicates RNA Editing in Cancer Innate Immunity and Patient Prognosis Open
Supplementary Figures S1-11 and Tables S1-2 are included in this file
View article: Supplementary Figures and Tables from Single-Cell Analysis in Lung Adenocarcinoma Implicates RNA Editing in Cancer Innate Immunity and Patient Prognosis
Supplementary Figures and Tables from Single-Cell Analysis in Lung Adenocarcinoma Implicates RNA Editing in Cancer Innate Immunity and Patient Prognosis Open
Supplementary Figures S1-11 and Tables S1-2 are included in this file
View article: Data from Single-Cell Analysis in Lung Adenocarcinoma Implicates RNA Editing in Cancer Innate Immunity and Patient Prognosis
Data from Single-Cell Analysis in Lung Adenocarcinoma Implicates RNA Editing in Cancer Innate Immunity and Patient Prognosis Open
RNA editing modifies single nucleotides of RNAs, regulating primary protein structure and protein abundance. In recent years, the diversity of proteins and complexity of gene regulation associated with RNA editing dysregulation has been in…
View article: Data from Single-Cell Analysis in Lung Adenocarcinoma Implicates RNA Editing in Cancer Innate Immunity and Patient Prognosis
Data from Single-Cell Analysis in Lung Adenocarcinoma Implicates RNA Editing in Cancer Innate Immunity and Patient Prognosis Open
RNA editing modifies single nucleotides of RNAs, regulating primary protein structure and protein abundance. In recent years, the diversity of proteins and complexity of gene regulation associated with RNA editing dysregulation has been in…
GPDs in asymmetric frames Open
It is often taken for granted that Generalized Parton Distributions (GPDs) are defined in the "symmetric" frame, where the transferred momentum is symmetrically distributed between the incoming/outgoing hadrons. However, such frames pose c…
GPDs in asymmetric frames Open
It is often taken for granted that Generalized Parton Distributions (GPDs) are defined in the "symmetric" frame, where the transferred momentum is symmetrically distributed between the incoming/outgoing hadrons. However, such frames pose c…
Accessing proton GPDs in asymmetric frames: Numerical implementation Open
In this work, we present a numerical investigation of a novel Lorentz-covariant parametrization to extract $x$-dependent GPDs using off-forward matrix elements of momentum-boosted hadrons coupled to non-local operators. The novelty of the …
Accessing proton GPDs in asymmetric frames: Numerical implementation Open
In this work, we present a numerical investigation of a novel Lorentz-covariant parametrization to extract $x$-dependent GPDs using off-forward matrix elements of momentum-boosted hadrons coupled to non-local operators. The novelty of the …
View article: Single-Cell Analysis in Lung Adenocarcinoma Implicates RNA Editing in Cancer Innate Immunity and Patient Prognosis
Single-Cell Analysis in Lung Adenocarcinoma Implicates RNA Editing in Cancer Innate Immunity and Patient Prognosis Open
RNA editing modifies single nucleotides of RNAs, regulating primary protein structure and protein abundance. In recent years, the diversity of proteins and complexity of gene regulation associated with RNA editing dysregulation has been in…
Targeting Krebs-cycle-deficient renal cell carcinoma with Poly ADP-ribose polymerase inhibitors and low-dose alkylating chemotherapy Open
Loss-of-function mutations in genes encoding the Krebs cycle enzymes Fumarate Hydratase (FH) and Succinate Dehydrogenase (SDH) induce accumulation of fumarate and succinate, respectively and predispose patients to hereditary cancer syndrom…
Generalized Parton Distributions from Lattice QCD with Asymmetric Momentum Transfer: Unpolarized Quarks Open
Traditionally, lattice QCD computations of generalized parton distributions (GPDs) have been carried out in a symmetric frame, where the transferred momentum is symmetrically distributed between the incoming and outgoing hadrons. However, …
Benchmarking of a Bayesian single cell RNAseq differential gene expression test for dose–response study designs Open
The application of single-cell RNA sequencing (scRNAseq) for the evaluation of chemicals, drugs, and food contaminants presents the opportunity to consider cellular heterogeneity in pharmacological and toxicological responses. Current diff…
Effects of periodic bottlenecks on the dynamics of adaptive evolution in microbial populations Open
Population bottlenecks are common in nature, and they can impact the rate of adaptation in evolving populations. On the one hand, each bottleneck reduces the genetic variation that fuels adaptation. On the other hand, each founder that sur…
First Lattice QCD Study of Proton Twist-3 GPDs Open
We present first results on selected twist-3 quark GPDs using the quasi-distribution method. This approach relates lattice QCD data and light-cone distribution functions using Large Momentum Effective Theory (LaMET). We calculate quark-ant…
The glutathione import system satisfies the <i>Staphylococcus aureus</i> nutrient sulfur requirement and promotes interspecies competition Open
Sulfur is an indispensable element for proliferation of bacterial pathogens. Prior studies indicated that the human pathogen, Staphylococcus aureus utilizes glutathione (GSH) as a source of nutrient sulfur; however, mechanisms of GSH acqui…
Benchmarking of a Bayesian single cell RNAseq differential gene expression test for dose-response study designs Open
The application of single-cell RNA sequencing (scRNAseq) for the evaluation of chemicals, drugs, and food contaminants presents the opportunity to consider cellular heterogeneity in pharmacological and toxicological responses. Current diff…
The Staphylococcus aureus Cystine Transporters TcyABC and TcyP Facilitate Nutrient Sulfur Acquisition during Infection Open
Staphylococcus aureus is a significant human pathogen due to its capacity to cause a multitude of diseases. As such, S. aureus efficiently pillages vital nutrients from the host; however, the molecular mechanisms that support sulfur acquis…