Jack Dorman
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View article: Constraint in West Nile virus envelope protein across mosquito, human, and avian host cell environments
Constraint in West Nile virus envelope protein across mosquito, human, and avian host cell environments Open
Arthropod-borne viruses are a major cause of global viral infections, displaying evolutionary dynamics that differ significantly from vertebrate-specific pathogens. To investigate evolutionary constraints across host environments, we condu…
View article: National genomic profiling of Plasmodium falciparum antimalarial resistance in Zambian children participating in the 2018 Malaria Indicator Survey
National genomic profiling of Plasmodium falciparum antimalarial resistance in Zambian children participating in the 2018 Malaria Indicator Survey Open
The emergence of antimalarial drug resistance is a major threat to malaria control and elimination. Using whole genome sequencing of 282 P. falciparum samples collected during the 2018 Zambia National Malaria Indicator Survey, we determine…
View article: National genomic profiling of<i>Plasmodium falciparum</i>antimalarial resistance in Zambian children participating in the 2018 Malaria Indicator Survey
National genomic profiling of<i>Plasmodium falciparum</i>antimalarial resistance in Zambian children participating in the 2018 Malaria Indicator Survey Open
The emergence of antimalarial drug resistance is a major threat to malaria control and elimination. Using whole genome sequencing of 282 P. falciparum samples collected during the 2018 Zambia National Malaria Indicator Survey, we determine…
View article: A metagenomic analysis of the phase 2 Anopheles gambiae 1000 genomes dataset reveals a wide diversity of cobionts associated with field collected mosquitoes
A metagenomic analysis of the phase 2 Anopheles gambiae 1000 genomes dataset reveals a wide diversity of cobionts associated with field collected mosquitoes Open
The Anopheles gambiae 1000 Genomes (Ag1000G) Consortium previously utilized deep sequencing methods to catalogue genetic diversity across African An. gambiae populations. We analyzed the complete datasets of 1142 individually sequenced mos…
View article: Genomics reveals heterogeneous<i>Plasmodium falciparum</i>transmission and population differentiation in Zambia and bordering countries
Genomics reveals heterogeneous<i>Plasmodium falciparum</i>transmission and population differentiation in Zambia and bordering countries Open
Genomic surveillance plays a critical role in monitoring malaria transmission and understanding how the parasite adapts in response to interventions. We conducted genomic surveillance of malaria by sequencing 241 Plasmodium falciparum geno…
View article: A metagenomic analysis of the phase 2 Anopheles gambiae 1000 genomes dataset reveals a wide diversity of cobionts associated with field collected mosquitoes
A metagenomic analysis of the phase 2 Anopheles gambiae 1000 genomes dataset reveals a wide diversity of cobionts associated with field collected mosquitoes Open
The Anopheles gambiae 1000 Genomes (Ag1000G) Consortium utilized deep sequencing methods to catalogue genetic diversity across African Anopheles gambiae populations. We analyzed the complete datasets of 1,142 individually sequenced mosquit…
View article: Genomic Surveillance of SARS-CoV-2 in a University Community: Insights Into Tracking Variants, Transmission, and Spread of Gamma (P.1) Variant
Genomic Surveillance of SARS-CoV-2 in a University Community: Insights Into Tracking Variants, Transmission, and Spread of Gamma (P.1) Variant Open
Background Using a combination of data from routine surveillance, genomic sequencing, and phylogeographic analysis, we tracked the spread and introduction events of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants focu…
View article: Genomic surveillance of SARS-CoV-2 in a university community: insights into tracking variants, transmission, and spread of Gamma (P.1) variant
Genomic surveillance of SARS-CoV-2 in a university community: insights into tracking variants, transmission, and spread of Gamma (P.1) variant Open
Using a combination of data from routine surveillance, genomic sequencing, and phylogeographic analysis we tracked the spread and introduction events of SARS-CoV-2 variants focusing on a large university community. Here, we sequenced and a…
View article: SARS-CoV-2 Breakthrough Infections in Fully Vaccinated Individuals
SARS-CoV-2 Breakthrough Infections in Fully Vaccinated Individuals Open
Importance While COVID-19 vaccines are highly effective against disease, breakthrough infections may occur in the context of rising variants of concern. Objective We paired random and passive surveillance nucleic acid testing with analysis…
View article: Optimized HT gDNA extraction from Dried Blood Spot using QIAcube HT for Malaria Genomic Epidemiology Studies v1
Optimized HT gDNA extraction from Dried Blood Spot using QIAcube HT for Malaria Genomic Epidemiology Studies v1 Open
Genomic DNA (gDNA) extracts from human dried blood spots (DBS) are commonly used for infectious diseases surveillance, genomic epidemiology studies of targeted pathogens, and Biobanking. In particular, DBS samples are routinely collected d…
View article: High-Throughput gDNA Extraction of Mosquito Tissues using QIAcube HT v1
High-Throughput gDNA Extraction of Mosquito Tissues using QIAcube HT v1 Open
Genomic DNA (gDNA) is crucial to the study of many important aspects of vector-parasite interactions of vector-borne diseases. Many studies operate at the population level of those diseases and as such, it is of immense value to have a hig…