Jack Moore
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View article: The ER thioredoxin-related transmembrane protein TMX2 controls redox-mediated tethering of ER-mitochondria contacts
The ER thioredoxin-related transmembrane protein TMX2 controls redox-mediated tethering of ER-mitochondria contacts Open
Thioredoxin-related transmembrane proteins (TMXs) of the endoplasmic reticulum (ER) determine not only redox conditions within the ER lumen but also the formation and function of ER-mitochondria membrane contact sites (ERMCS). The presence…
View article: The ER Thioredoxin-Related Transmembrane Protein TMX2 Controls Redox-Mediated Tethering of ER-Mitochondria Contacts (ERMCS)
The ER Thioredoxin-Related Transmembrane Protein TMX2 Controls Redox-Mediated Tethering of ER-Mitochondria Contacts (ERMCS) Open
Summary Thioredoxin-related transmembrane proteins (TMX) of the endoplasmic reticulum (ER) have emerged as key regulators of ER membrane properties. Within the ER lumen, TMX proteins and other ER redox enzymes determine oxidative condition…
View article: Cost-effective selective deuteration of aromatic amino acid residues produces long-lived solution 1H NMR magnetization in proteins
Cost-effective selective deuteration of aromatic amino acid residues produces long-lived solution 1H NMR magnetization in proteins Open
Solution NMR studies of large proteins are hampered by rapid signal decay due to short-range dipolar 1H-1H and 1H-13C interactions. These are attenuated by rapid rotation in methyl groups and by deuteration (2H), so selective 1H,13C-isotop…
View article: The endoplasmic reticulum kinase PERK interacts with the oxidoreductase ERO1 to metabolically adapt mitochondria
The endoplasmic reticulum kinase PERK interacts with the oxidoreductase ERO1 to metabolically adapt mitochondria Open
Endoplasmic reticulum (ER) homeostasis requires molecular regulators that tailor mitochondrial bioenergetics to the needs of protein folding. For instance, calnexin maintains mitochondria metabolism and mitochondria-ER contacts (MERCs) thr…
View article: Assessment of Clinical and Biochemical Factors at Initiation of Dialysis for Acute Kidney Injury (AKI) in the ICU on In-Hospital Mortality
Assessment of Clinical and Biochemical Factors at Initiation of Dialysis for Acute Kidney Injury (AKI) in the ICU on In-Hospital Mortality Open
Rationale: Current research on renal replacement therapy (RRT) focuses on analyzing survival outcomes by arbitrarily defining timing as "early" or "late" whereas the impact of co-existing factors such as clinical comorbidities, dialysis in…
View article: Kidney retransplantation after anti–programmed cell death-1 (PD-1)–related allograft rejection
Kidney retransplantation after anti–programmed cell death-1 (PD-1)–related allograft rejection Open
In this report, we describe the first kidney retransplantation performed after anti-programmed cell death-1 (PD-1)-related allograft rejection. In 2014, we administered pembrolizumab (anti-PD-1) for ~9 months to a 57-year-old kidney transp…
View article: Transplant nephrectomy with peritoneal window: Georgetown University experience
Transplant nephrectomy with peritoneal window: Georgetown University experience Open
Transplant nephrectomy with peritoneal window is a technique with better results compared to the literature. An opening between the transplant cavity and the peritoneum allows for passive drainage of fluid and minimizes the risk of hematom…
View article: Identification and Characterization of Novel Receptor-Interacting Serine/Threonine‐Protein Kinase 2 Inhibitors Using Structural Similarity Analysis
Identification and Characterization of Novel Receptor-Interacting Serine/Threonine‐Protein Kinase 2 Inhibitors Using Structural Similarity Analysis Open
Receptor-interacting protein kinase 2 (RIP2 or RICK, herein referred to as RIPK2) is linked to the pathogen pathway that activates nuclear factor κ-light-chain-enhancer of activated B cells (NFκB) and autophagic activation. Using molecular…
View article: The sole LSm complex in <i>Cyanidioschyzon merolae</i> associates with pre-mRNA splicing and mRNA degradation factors
The sole LSm complex in <i>Cyanidioschyzon merolae</i> associates with pre-mRNA splicing and mRNA degradation factors Open
Proteins of the Sm and Sm-like (LSm) families, referred to collectively as (L)Sm proteins, are found in all three domains of life and are known to promote a variety of RNA processes such as base-pair formation, unwinding, RNA degradation, …
View article: Tumor Regression and Allograft Rejection after Administration of Anti–PD-1
Tumor Regression and Allograft Rejection after Administration of Anti–PD-1 Open
Cancers, especially skin cancers, may develop in patients undergoing solid-organ transplantation who receive long-term immunosuppression. The use of anti–PD-1 in one such patient produced an antitumor response but led to rejection of the t…