Jack Munns
YOU?
Author Swipe
View article: Development of compounds for targeted degradation of mammalian cryptochrome proteins.
Development of compounds for targeted degradation of mammalian cryptochrome proteins. Open
The mammalian cryptochrome proteins (CRY1 and CRY2) are transcriptional repressors most notable for their role in circadian transcriptional feedback. Not all circadian rhythms depend on CRY proteins, however, and the CRY proteins are promi…
View article: Chronic CRYPTOCHROME deficiency enhances cell-intrinsic antiviral defences
Chronic CRYPTOCHROME deficiency enhances cell-intrinsic antiviral defences Open
The within-host environment changes over circadian time and influences the replication and severity of viruses. Genetic knockout of the circadian transcription factors CRYPTOCHROME 1 and CRYPTOCHROME 2 ( CRY1 −/− / CRY2 −/− ; CKO) leads to…
View article: The rhythmic transcriptional landscape in<i>Caenorhabditis elegans</i>: daily, circadian and novel 16-hour cycling gene expression revealed by RNA-sequencing
The rhythmic transcriptional landscape in<i>Caenorhabditis elegans</i>: daily, circadian and novel 16-hour cycling gene expression revealed by RNA-sequencing Open
The nematode Caenorhabditis elegans is an unconventional model in chronobiology, reported to exhibit physiological and behavioural circadian rhythms while lacking a defined transcriptional oscillator. The extent and importance of circadian…
View article: Circadian regulation of macromolecular complex turnover and proteome renewal
Circadian regulation of macromolecular complex turnover and proteome renewal Open
Although costly to maintain, protein homeostasis is indispensable for normal cellular function and long-term health. In mammalian cells and tissues, daily variation in global protein synthesis has been observed, but its utility and consequ…
View article: Multiple Pathways of LRRK2-G2019S/Rab10 Interaction in Dopaminergic Neurons
Multiple Pathways of LRRK2-G2019S/Rab10 Interaction in Dopaminergic Neurons Open
Background: Inherited mutations in the LRRK2 protein are common causes of Parkinson’s disease, but the mechanisms by which increased kinase activity of mutant LRRK2 leads to pathological events remain to be determined. In vitro assays (het…
View article: Selective human tau protein expression in different clock circuits of the<i>Drosophila</i>brain disrupts different aspects of sleep and circadian rhythms
Selective human tau protein expression in different clock circuits of the<i>Drosophila</i>brain disrupts different aspects of sleep and circadian rhythms Open
Circadian behavioural deficits, such as increased daytime naps and reduced night-time sleep, are common in Alzheimer’s disease and other tauopathies. But it has remained unclear whether these circadian abnormalities arise from tau patholog…
View article: Multiple pathways of LRRK2-G2019S / Rab10 interaction in dopaminergic neurons
Multiple pathways of LRRK2-G2019S / Rab10 interaction in dopaminergic neurons Open
Background Inherited mutations in the LRRK2 protein are the most common known cause of Parkinson’s, but the mechanisms by which increased kinase activity of mutant LRRK2 leads to pathological events remain to be determined. In vitro assays…
View article: Wavelet spectral testing: Application to nonstationary circadian rhythms
Wavelet spectral testing: Application to nonstationary circadian rhythms Open
Rhythmic data are ubiquitous in the life sciences. Biologists need reliable statistical tests to identify whether a particular experimental treatment has caused a significant change in a rhythmic signal. When these signals display nonstati…
View article: Neurodegeneration caused by LRRK2-G2019S requires Rab10 in select dopaminergic neurons
Neurodegeneration caused by LRRK2-G2019S requires Rab10 in select dopaminergic neurons Open
Inherited mutations in the LRRK2 protein are the commonest known cause of Parkinson’s, but the molecular link from increased kinase activity to pathological neurodegeneration remains to be determined. In vitro (biochemical and cell culture…