J. C. Ng
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View article: Supplementation of trehalulose in stingless bee honey improved glucose tolerance and insulin sensitivity in Type 2 Diabetic-induced rats <i>In Vivo</i>
Supplementation of trehalulose in stingless bee honey improved glucose tolerance and insulin sensitivity in Type 2 Diabetic-induced rats <i>In Vivo</i> Open
Hyperglycemia is defined as excessive blood glucose levels and often leads to a diagnosis of type 2 diabetes. Trehalulose, a rare disaccharide with a low glycemic index, was recently discovered to be a unique major bioactive component in s…
View article: Extracellular vesicles as delivery vehicles and therapeutic agents for glioblastoma treatment: A systematic review of in vitro and in vivo preclinical studies
Extracellular vesicles as delivery vehicles and therapeutic agents for glioblastoma treatment: A systematic review of in vitro and in vivo preclinical studies Open
Current treatments for glioblastoma face challenges such as the blood-brain barrier and lack of targeted therapy, compounded by the aggressive nature, high invasiveness, and heterogeneity of the disease. Exosomes, a subtype of extracellula…
View article: Therapeutic Drug Monitoring: Comparison of Direct Proportion Approach Versus Conventional Method for Dose Adjustment of Carbamazepine
Therapeutic Drug Monitoring: Comparison of Direct Proportion Approach Versus Conventional Method for Dose Adjustment of Carbamazepine Open
Introduction: Therapeutic Drug Monitoring (TDM) is useful and significant for drugs with a narrow therapeutic index. One of the common drugs requiring TDM is carbamazepine. Conventional pharmacokinetic approach in drug dosage adjustment pr…
View article: Urinary arsenic speciation in a Brazilian population serving as a baseline for future environmental biomonitoring studies
Urinary arsenic speciation in a Brazilian population serving as a baseline for future environmental biomonitoring studies Open
Minas Gerais (MG) is a mineral-rich State in Brazil hosting mining activities since the late 17th century, when large gold deposits were discovered. Arsenic contamination is often associated with precious and base-metal extraction. It is s…
View article: Arsenic speciation in dust dispersion from mining to Mount Isa city
Arsenic speciation in dust dispersion from mining to Mount Isa city Open
The study has sought to understand why higher % bioaccessibilities (BAc's) were observed for the risk assessment of As exposure to the population of Mount Isa for surface tailings and city fallout dust. The current study examined the speci…
View article: Uncovering the impact of mega-scale shipbreaking yards on soil and crop quality in Bangladesh: A spatiotemporal dynamics and associated health risks of metal/loid contamination
Uncovering the impact of mega-scale shipbreaking yards on soil and crop quality in Bangladesh: A spatiotemporal dynamics and associated health risks of metal/loid contamination Open
The uncontrolled release of harmful metal/loids from mega-scale shipbreaking activities in Bangladesh is a significant concern. This study investigated the impact of shipbreaking activities on soil and crop quality and human health in rela…
View article: Relationships between growth indicators, liver and kidney function markers, and blood concentrations of essential and potentially toxic elements in environmentally exposed young children
Relationships between growth indicators, liver and kidney function markers, and blood concentrations of essential and potentially toxic elements in environmentally exposed young children Open
Environmental exposure to multiple metals and metalloids is widespread, leading to a global concern relating to the adverse health effects of mixed-metals exposure, especially in young children living around industrial areas. This study ai…
View article: Speciated and Total Urinary Arsenic Levels in Belo Horizonte, the Largest Brazilian City within the Mineral-Rich Region “Iron Quadrangle”
Speciated and Total Urinary Arsenic Levels in Belo Horizonte, the Largest Brazilian City within the Mineral-Rich Region “Iron Quadrangle” Open
The “Quadrilátero Ferrífero” (Iron Quadrangle) is a mineral-rich province in Brazil, where arsenic anomalies are associated with gold mining and tailings dam failures. Urine samples were randomly collected from residents of Belo Horizonte …
View article: Human Exposure Assessment of Mixed Metal/Loids at and Near Mega-Scale Open Beaching Shipwrecking Activities in Bangladesh
Human Exposure Assessment of Mixed Metal/Loids at and Near Mega-Scale Open Beaching Shipwrecking Activities in Bangladesh Open
Pollution from shipwrecking is growing into a major occupational and environmental health concern worldwide, especially in the lower-middle-income countries where workers and residents may be exposed to potentially high levels of dispersed…
View article: Effect of basal metabolic rate on cancer: a Mendelian randomization study
Effect of basal metabolic rate on cancer: a Mendelian randomization study Open
Supplementary tables
View article: Investigating the Use of Layered Double Hydroxide Nanoparticles as Carriers of Metal Oxides for Theranostics of ROS-Related Diseases
Investigating the Use of Layered Double Hydroxide Nanoparticles as Carriers of Metal Oxides for Theranostics of ROS-Related Diseases Open
Overproduction of reactive oxygen species (ROS) is commonly known as a key factor in the progression of many chronic inflammation diseases such as atherosclerosis and rheumatoid arthritis. In this study, a metal oxide nanodot-coated layere…
View article: Health risk assessment of arsenic dispersion from mining in Mount Isa
Health risk assessment of arsenic dispersion from mining in Mount Isa Open
The study identified that arsenic (As) exposure to the population of Mount Isa is of limited significance but surface tailings and fall out (city) may be higher risk because their % bioaccessibilities are higher than those of other sources…
View article: Interaction of polyaromatic hydrocarbons and metals on bioaccessibility and toxicity of arsenic
Interaction of polyaromatic hydrocarbons and metals on bioaccessibility and toxicity of arsenic Open
We investigated the interaction effects of cadmium, lead and four PAHs on the toxicity of arsenic and each other. A simulated in vitro human digestive system and human liver cell-based assays were employed to determine their respective bio…
View article: Validation and bioinformatics analysis of differentially expressed circRNAs involved in developing male Xenopus laevis chronically exposed to atrazine
Validation and bioinformatics analysis of differentially expressed circRNAs involved in developing male Xenopus laevis chronically exposed to atrazine Open
The data presented here are related to the research article titled "Identification of circular RNAs and their alterations involved in developing male Xenopus laevis chronically exposed to atrazine" (Sai et al., 2018) [1]. Circular RNAs (ci…
View article: Addressing Food Insecurity in Papua New Guinea Through Food Safety and Sago Cropping
Addressing Food Insecurity in Papua New Guinea Through Food Safety and Sago Cropping Open
Papua New Guinea (PNG) is known to have a large resource base of sago with over 1 million ha, as well as a high number of germplasm types of the Metroxylon species. The country’s food security status is very low and is primarily dependent …
View article: Erratum: Addressing Food Insecurity in Papua New Guinea Through Food Safety and Sago Cropping
Erratum: Addressing Food Insecurity in Papua New Guinea Through Food Safety and Sago Cropping Open
Papua New Guinea (PNG) is known to have a large resource base of sago with over 1 million ha, as well as a high number of germplasm types of the Metroxylon species. The country’s food security status is very low and is primarily dependent …
View article: X-ray absorption spectroscopy for lead speciation of dispersed mine waste
X-ray absorption spectroscopy for lead speciation of dispersed mine waste Open
The Lead Pathway Air Study (2007Study ( -2012) ) was a large study [1] on the human exposure to lead undertaken at Mount Isa, Queensland, Australia.Mount Isa Mines is located west of the city and has mined and processed lead-zinc and coppe…
View article: Inhibition of gap junction intercellular communication is involved in silica nanoparticles-induced H9c2 cardiomyocytes apoptosis via the mitochondrial pathway
Inhibition of gap junction intercellular communication is involved in silica nanoparticles-induced H9c2 cardiomyocytes apoptosis via the mitochondrial pathway Open
Gap junction intercellular communication (GJIC) between cardiomyocytes is essential for synchronous heart contraction and relies on connexin-containing channels. Connexin 43 (Cx43) is a major component involved in GJIC in heart tissue, and…
View article: The binary, ternary and quaternary mixture toxicity of benzo[a]pyrene, arsenic, cadmium and lead in HepG2 cells
The binary, ternary and quaternary mixture toxicity of benzo[a]pyrene, arsenic, cadmium and lead in HepG2 cells Open
The toxicity of multi-component mixtures of B[a]P and heavy metal/loid(s) was determined in HepG2 cells. Concentration dependent synergism, additivity or antagonism was predicted by the combination-index isobologram method.
View article: Effects of multi-component mixtures of polyaromatic hydrocarbons and heavy metal/loid(s) on Nrf2-antioxidant response element (ARE) pathway in ARE reporter-HepG2 cells
Effects of multi-component mixtures of polyaromatic hydrocarbons and heavy metal/loid(s) on Nrf2-antioxidant response element (ARE) pathway in ARE reporter-HepG2 cells Open
The effect of mixtures of PAHs and heavy metal/loid(s) on the Nrf2 antioxidant pathway in HepG2-ARE cells was determined as an indicator of the oxidative stress response.
View article: The Role of Epigenetic Changes in Benzene- Induced Acute Myeloid Leukaemia
The Role of Epigenetic Changes in Benzene- Induced Acute Myeloid Leukaemia Open
Acute myeloid leukaemia (AML) is a malignant cancer in blood and bone marrow with overall survival rate about 25% in adult. The main pathological changes of AML involve the dysfunctions of hematopoietic stem and progenitor cells including …
View article: A review of non-exhaustive chemical and bioavailability methods for the assessment of polycyclic aromatic hydrocarbons in soil
A review of non-exhaustive chemical and bioavailability methods for the assessment of polycyclic aromatic hydrocarbons in soil Open
Current environmental regulations relating to risk assessment for contaminated sites are often set assuming that the contaminant is 100% bioavailable. It is therefore not surprising that remediation of contaminated sites is very expensive …