Jack Rychik
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View article: Clinical Characteristics Associated With Variability in Biopsy Grade Severity of Liver Fibrosis in Fontan Circulation
Clinical Characteristics Associated With Variability in Biopsy Grade Severity of Liver Fibrosis in Fontan Circulation Open
Liver fibrosis in FC progresses with duration of exposure, independent of venous pressure, suggesting ongoing fibrogenesis even at acceptable hemodynamics. Younger age at FO is associated with greater fibrosis severity and may represent a …
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View article: Promoting emotional & behavioral health for pediatric patients with Fontan circulation: integrating psychology into a dedicated multidisciplinary clinic
Promoting emotional & behavioral health for pediatric patients with Fontan circulation: integrating psychology into a dedicated multidisciplinary clinic Open
Introduction Individuals with single ventricle congenital heart disease and Fontan circulation are at high risk for mental health problems. There is a lack of information about potential care models to address these common challenges. This…
View article: Selective Fetoscopic Laser Photocoagulation of Placental Anastomoses Leads to Early Reduction of Cardiovascular Burden in the Twin‐Twin Transfusion Syndrome
Selective Fetoscopic Laser Photocoagulation of Placental Anastomoses Leads to Early Reduction of Cardiovascular Burden in the Twin‐Twin Transfusion Syndrome Open
Objective Cardiovascular disturbances are common in twin‐twin transfusion syndrome (TTTS). However, the rate of improvement in cardiovascular burden in response to selective fetoscopic laser photocoagulation (SFLP) is not well known. Metho…
View article: Experimental Impact of Increasing Circuit Resistance in the Artificial Womb
Experimental Impact of Increasing Circuit Resistance in the Artificial Womb Open
Objective To determine the impact of controlled incremental changes in circuit blood flow resistance to the oxygenator on hemodynamics in the fetal lamb supported by the EXTrauterine Environment for Neonatal Development (EXTEND) system. Me…
View article: Alterations in Liver Perfusion in Adults With Fontan Circulation as Assessed by Dual Cholate Clearance
Alterations in Liver Perfusion in Adults With Fontan Circulation as Assessed by Dual Cholate Clearance Open
Background Fontan circulation (FC) in complex congenital heart disease is characterized by altered hemodynamics and associated with Fontan‐associated liver disease. Patients with FC may exhibit abnormalities in cholate clearance due to abn…
View article: Comprehensive Multiomic Analysis Reveals Metabolic Reprogramming Underlying Human Fontan‐Associated Liver Disease
Comprehensive Multiomic Analysis Reveals Metabolic Reprogramming Underlying Human Fontan‐Associated Liver Disease Open
Background The Fontan operation is the current standard of care for single‐ventricle congenital heart disease. Almost all patients with Fontan operation develop liver fibrosis at a young age, known as Fontan‐associated liver disease (FALD)…
View article: Placental Microvascular Architecture Imaging in Normal and Congenital Heart Disease Pregnancies
Placental Microvascular Architecture Imaging in Normal and Congenital Heart Disease Pregnancies Open
Objectives To evaluate the placental vascular architecture using MV Flow™ imaging for analyzing vascular distribution per region of biological tissue in isolated congenital heart diseases (CHD), CHD associated with extracardiac malformatio…
View article: Transitioning from the safety of the womb to the outside world for neonates with life-threatening cardiovascular conditions: The IMmediate Postpartum Access to Cardiac Therapy (IMPACT) Procedure
Transitioning from the safety of the womb to the outside world for neonates with life-threatening cardiovascular conditions: The IMmediate Postpartum Access to Cardiac Therapy (IMPACT) Procedure Open
The IMmediate Postpartum Access to Cardiac Therapy (IMPACT) procedure is a multidisciplinary, collaborative, highly coordinated clinical service in which a planned delivery and intensive neonatal care are offered for conditions where there…
View article: Associations Between Exercise Capacity and Psychological Functioning in Children and Adolescents with Fontan Circulation
Associations Between Exercise Capacity and Psychological Functioning in Children and Adolescents with Fontan Circulation Open
Individuals with Fontan circulation (FC) often have diminished exercise capacity and are at risk for psychological problems. The current study examines associations between exercise capacity and psychological functioning in children and ad…
View article: Noninvasive Optical Monitoring of Cerebral Hemodynamics Immediately after Birth in Neonates with Congenital Heart Disease
Noninvasive Optical Monitoring of Cerebral Hemodynamics Immediately after Birth in Neonates with Congenital Heart Disease Open
Objective Critical congenital heart disease (CHD) is associated with neuropsychiatric impairment that may stem from altered cerebral hemodynamics. While cerebral hemodynamics are shown to differ in neonates with CHD, the effect of CHD on c…
View article: Hey, look over here! Perspectives on the role of monitoring during fetal surgery
Hey, look over here! Perspectives on the role of monitoring during fetal surgery Open
Linked article: This Editorial comments on the article by Backley et al. Click here to view the article.
View article: Is there an increased risk of genetic abnormalities in fetuses with congenital heart disease in the setting of growth restriction?
Is there an increased risk of genetic abnormalities in fetuses with congenital heart disease in the setting of growth restriction? Open
Objective To determine if the presence of fetal growth restriction (FGR) is associated with an increased risk of genetic abnormalities in the setting of congenital heart disease (CHD). Methods This was a retrospective cohort study involvin…
View article: Progesterone for Neurodevelopment in Fetuses With Congenital Heart Defects
Progesterone for Neurodevelopment in Fetuses With Congenital Heart Defects Open
Importance Neurodevelopmental outcomes for children with congenital heart defects (CHD) have improved minimally over the past 20 years. Objectives To assess the feasibility and tolerability of maternal progesterone therapy as well as the m…
View article: Single-cell multiomics guided mechanistic understanding of Fontan-associated liver disease
Single-cell multiomics guided mechanistic understanding of Fontan-associated liver disease Open
The Fontan operation is the current standard of care for single-ventricle congenital heart disease. Individuals with a Fontan circulation (FC) exhibit central venous hypertension and face life-threatening complications of hepatic fibrosis,…
View article: Role of maternal hyperoxygenation in predicting need for postnatal balloon atrial septostomy in fetal d‐transposition of the great arteries
Role of maternal hyperoxygenation in predicting need for postnatal balloon atrial septostomy in fetal d‐transposition of the great arteries Open
Objective Predicting whether postnatal balloon atrial septostomy (BAS) will be necessary for fetuses with dextro‐transposition of the great arteries (d‐TGA) remains challenging. We sought to determine whether fetal echocardiographic measur…
View article: Associations Between Exercise Capacity and Psychological Functioning in Children and Adolescents with Fontan Circulation
Associations Between Exercise Capacity and Psychological Functioning in Children and Adolescents with Fontan Circulation Open
Background Pediatric patients with Fontan circulation (FC) often have diminished exercise capacity. They are also at risk for psychological problems, including anxiety, depression, and inattention. The current study examines associations b…
View article: ISUOG Practice Guidelines (updated): fetal cardiac screening
ISUOG Practice Guidelines (updated): fetal cardiac screening Open
These guidelines may have been translated, from the originals published by ISUOG, by recognized experts in the field and have been independently verified by reviewers with a relevant first language. Although all reasonable endeavors have b…
View article: Prenatal cardiac findings and 22q11.2 deletion syndrome: Fetal detection and evaluation
Prenatal cardiac findings and 22q11.2 deletion syndrome: Fetal detection and evaluation Open
Clinical features of 22q11.2 microdeletion syndrome (22q11.2DS) are highly variable between affected individuals and frequently include a subset of conotruncal and aortic arch anomalies. Many are diagnosed with 22q11.2DS when they present …
View article: Enlarged cavum septum pellucidum and small thymus as markers for 22q11.2 deletion syndrome
Enlarged cavum septum pellucidum and small thymus as markers for 22q11.2 deletion syndrome Open
Background Enlarged cavum septum pellucidum (CSP) and hypoplastic thymus are proposed extra‐cardiac fetal markers for 22q11.2 deletion syndrome. We sought to determine if they were part of the fetal phenotype of our cohort of fetuses with …