Jack S. Hardwick
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View article: SCoTCH-seq reveals that 5-hydroxymethylcytosine encodes regulatory information across DNA strands
SCoTCH-seq reveals that 5-hydroxymethylcytosine encodes regulatory information across DNA strands Open
In mammalian genomes, cytosine modifications form a layer of regulatory information alongside the genetic code. Decoding this information is crucial to our understanding of biology and disease. Established sequencing methods cannot simulta…
View article: CCDC 2105684: Experimental Crystal Structure Determination
CCDC 2105684: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2105685: Experimental Crystal Structure Determination
CCDC 2105685: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Oligonucleotide analogues with locked-amide linkages have therapeutic potential
Oligonucleotide analogues with locked-amide linkages have therapeutic potential Open
Oligonucleotides that target mRNA have great promise as therapeutic agents for life-threatening conditions but suffer from poor bioavailability, hence high cost. As currently untreatable diseases come within the reach of oligonucleotide th…
View article: 2′-Alkynyl spin-labelling is a minimally perturbing tool for DNA structural analysis
2′-Alkynyl spin-labelling is a minimally perturbing tool for DNA structural analysis Open
The determination of distances between specific points in nucleic acids is essential to understanding their behaviour at the molecular level. The ability to measure distances of 2–10 nm is particularly important: deformations arising from …
View article: Simulating hydrates in shallow marine sediments
Simulating hydrates in shallow marine sediments Open
With global energy needs growing alongside a drive to reduce carbon emissions, there is a demand for cleaner, alternative energy. Methane hydrates are one such resource that is being investigated with the goal of future potential exploitat…
View article: Masuda’s sandstone core hydrate dissociation experiment revisited
Masuda’s sandstone core hydrate dissociation experiment revisited Open
Numerical simulation of hydrate dissociation in porous media is important to investigate future hydrate fuel extraction strategies and/or the impacts of climate change on the long-term stability of vulnerable near-surface hydrate deposits.…