J. Carson Smith
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View article: Clinical utility of ECAP dosing in a real-world population delivered via EVOKE therapy: the ECAP study
Clinical utility of ECAP dosing in a real-world population delivered via EVOKE therapy: the ECAP study Open
Background The efficacy of EVOKE therapy, a closed-loop spinal cord stimulation (SCS) system, has been demonstrated in a double-blinded randomized controlled trial (RCT). RCT evidence, however, may not be generalizable to clinical practice…
View article: The Functional Connectome Mediates Associations Between Fitness and Cognition Across the Adult Lifespan
The Functional Connectome Mediates Associations Between Fitness and Cognition Across the Adult Lifespan Open
Cardiorespiratory fitness (CRF) is increasingly recognized as essential for improving neural and cognitive function, especially in older age. Here, we examined a cross‐sectional sample of the Human Connectome Project (HCP) Aging dataset (a…
View article: Functional brain network correlates of cardiorespiratory fitness and moderation by depression symptoms
Functional brain network correlates of cardiorespiratory fitness and moderation by depression symptoms Open
Cardiorespiratory fitness may protect against or alleviate depression through neuroplastic mechanisms within disrupted brain networks underlying cognitive and affective symptoms. There is a scarcity of research examining the effects of car…
View article: Protocol of a randomized, single-blind, controlled trial of an 18-month, home-based, high-intensity, exercise intervention in older, cognitively unimpaired APOE ε4 carriers
Protocol of a randomized, single-blind, controlled trial of an 18-month, home-based, high-intensity, exercise intervention in older, cognitively unimpaired APOE ε4 carriers Open
Background The World Health Organization highlighted the potential protective role of exercise against cognitive decline, all-cause dementia, Alzheimer’s disease (AD), and vascular dementia in healthy individuals. We have previously shown …
View article: Acute Exercise Improves Large-Scale Brain Network Segregation in Healthy Older Adults
Acute Exercise Improves Large-Scale Brain Network Segregation in Healthy Older Adults Open
Introduction: Age-related cognitive decline and mental health problems are accompanied by changes in resting-state functional connectivity (rsFC) indices, such as reduced brain network segregation. Meanwhile, exercise can improve cognition…
View article: Brain-wide functional connectome analysis of 40,000 individuals reveals brain networks that show aging effects in older adults
Brain-wide functional connectome analysis of 40,000 individuals reveals brain networks that show aging effects in older adults Open
The functional connectome changes with aging. We systematically evaluated aging related alterations in the functional connectome using a whole-brain connectome network analysis in 39,675 participants in UK Biobank project. We used adaptive…
View article: Brain-wide functional connectome analysis of 40,000 individuals reveals brain networks that show aging effects in older adults
Brain-wide functional connectome analysis of 40,000 individuals reveals brain networks that show aging effects in older adults Open
The functional connectome changes with aging. We systematically evaluated aging-related alterations in the functional connectome using a whole-brain connectome network analysis in 39,675 participants in UK Biobank project. We used adaptive…
View article: 5 Large-Scale Network Connectivity and Cognitive Function after Exercise Training in Older Adults
5 Large-Scale Network Connectivity and Cognitive Function after Exercise Training in Older Adults Open
Objective: Despite growing evidence regarding the association between exercise training (ET) and functional brain connectivity, little is known about the effects of ET on within- and between-network functional connectivity (FC) of core bra…
View article: Associations Between Classical Music, Physical Activity And Symptoms Of Depression In Older Adults During The Covid-19 Pandemic
Associations Between Classical Music, Physical Activity And Symptoms Of Depression In Older Adults During The Covid-19 Pandemic Open
Background: The initial lockdown in March 2020 due to COVID-19 rattled the residents of North America as normalcy came to a standstill, freedom was stripped away, and people were forced to adapt to new restrictions and regulations, simply …
View article: Hippocampal functional connectivity mediates the association between cardiorespiratory fitness and cognitive function in healthy young adults
Hippocampal functional connectivity mediates the association between cardiorespiratory fitness and cognitive function in healthy young adults Open
Objective: Higher cardiorespiratory fitness (CRF) induces neuroprotective effects in the hippocampus, a key brain region for memory and learning. We investigated the association between CRF and functional connectivity (FC) of the hippocamp…
View article: Acute cycling exercise and hippocampal subfield function and microstructure in healthy older adults
Acute cycling exercise and hippocampal subfield function and microstructure in healthy older adults Open
Aging is associated with deterioration in dentate gyrus (DG) and CA3, both crucial hippocampal subfields for age susceptible memory processes such as mnemonic discrimination (MD). Meanwhile, a single aerobic exercise session alters DG/CA3 …
View article: Emotional processing and positive affect after acute exercise in healthy older adults
Emotional processing and positive affect after acute exercise in healthy older adults Open
The well‐elucidated improvement of mood immediately after exercise in older adults presumably involves adaptations in emotion‐processing brain networks. However, little is known about effects of acute exercise on appetitive and aversive em…
View article: Large-Scale Network Connectivity and Cognitive Function Changes After Exercise Training in Older Adults with Intact Cognition and Mild Cognitive Impairment
Large-Scale Network Connectivity and Cognitive Function Changes After Exercise Training in Older Adults with Intact Cognition and Mild Cognitive Impairment Open
Background: Despite growing evidence regarding the association between exercise training (ET) and functional brain network connectivity, little is known about the effects of ET on large-scale within- and between-network functional connecti…
View article: Proceedings from the Albert Charitable Trust Inaugural Workshop on ‘Understanding the Acute Effects of Exercise on the Brain’
Proceedings from the Albert Charitable Trust Inaugural Workshop on ‘Understanding the Acute Effects of Exercise on the Brain’ Open
An inaugural workshop supported by “The Leo and Anne Albert Charitable Trust,” was held October 4–7, 2019 in Scottsdale, Arizona, to focus on the effects of exercise on the brain and to discuss how physical activity may prevent or delay th…
View article: Cardiorespiratory Fitness as a Moderator of Sleep-Related Associations with Hippocampal Volume and Cognition
Cardiorespiratory Fitness as a Moderator of Sleep-Related Associations with Hippocampal Volume and Cognition Open
The objective of this study was to understand the associations of sleep and cardiorespiratory fitness with hippocampal volume and global cognition among older adults (n = 30, age = 65.8 years, female = 73.3%). Wrist actigraphy provided obj…
View article: Effects of acute aerobic exercise on mnemonic discrimination performance in older adults
Effects of acute aerobic exercise on mnemonic discrimination performance in older adults Open
Objectives: Ample evidence suggests exercise is beneficial for hippocampal function. Furthermore, a single session of aerobic exercise provides immediate benefits to mnemonic discrimination performance, a highly hippocampal-specific memory…
View article: Subjective Well-Being and Bilateral Anterior Insula Functional Connectivity After Exercise Intervention in Older Adults With Mild Cognitive Impairment
Subjective Well-Being and Bilateral Anterior Insula Functional Connectivity After Exercise Intervention in Older Adults With Mild Cognitive Impairment Open
While it is well known that exercise training is associated with improvement in subjective well-being among older adults, it is unclear if individuals with cognitive impairment experience the same effects elicited by exercise on subjective…
View article: Differential associations of regional cerebellar volume with gait speed and working memory
Differential associations of regional cerebellar volume with gait speed and working memory Open
The relationship between gait speed and working memory is well-understood in older adults. However, it remains to be determined whether this relationship also exists in younger adults; and there is little known regarding the possible neura…
View article: Mediating Role of Cerebellar Subregion Volume in the Relationship Between Gait Speed and Working Memory
Mediating Role of Cerebellar Subregion Volume in the Relationship Between Gait Speed and Working Memory Open
Introduction: The relationship between gait speed and working memory is well-understood in older adults. However, it remains to be determined whether this relationship also exists in younger adults; and there is little known regarding the …
View article: Hippocampal Functional Connectivity and Memory Performance After Exercise Intervention in Older Adults with Mild Cognitive Impairment
Hippocampal Functional Connectivity and Memory Performance After Exercise Intervention in Older Adults with Mild Cognitive Impairment Open
Background: Exercise training (ET) has neuroprotective effects in the hippocampus, a key brain region for memory that is vulnerable to age-related dysfunction. Objective: We investigated the effects of ET on functional connectivity (FC) of…
View article: Cardiovascular Endurance Modifies the Link between Subjective Sleep Quality and Entorhinal Cortex Thickness in Younger Adults
Cardiovascular Endurance Modifies the Link between Subjective Sleep Quality and Entorhinal Cortex Thickness in Younger Adults Open
Introduction Poor sleep is linked to impaired cognitive function, cortical brain atrophy, and lower cortical thickness. Independently, higher cardiovascular endurance has neuroprotective effects. It remains in question, however, whether ca…