Jack Stenning
YOU?
Author Swipe
View article: An ERα-Dependent Hypoxia Response Defines EMT-Adjacent Tumour Regions and Suppresses the Pro-survival Effects of Amiloride in Estrogen Receptor-Positive Breast Cancer
An ERα-Dependent Hypoxia Response Defines EMT-Adjacent Tumour Regions and Suppresses the Pro-survival Effects of Amiloride in Estrogen Receptor-Positive Breast Cancer Open
Estrogen receptor-positive (ER+) breast cancer carries a lifelong risk of recurrence and disease progression, with hypoxia-associated transcriptional signatures linked to poor prognosis and therapy resistance. While the effects of hypoxia …
View article: Label-free DIA-NN enabled RIME (DIANNeR) reveals glucocorticoid receptor interaction networks in breast, bladder, and blood across normal untransformed cells, cancer cell lines, and PDXs
Label-free DIA-NN enabled RIME (DIANNeR) reveals glucocorticoid receptor interaction networks in breast, bladder, and blood across normal untransformed cells, cancer cell lines, and PDXs Open
The glucocorticoid receptor (GR) coordinates diverse transcriptional responses to glucocorticoids, regulating metabolism, inflammation, homeostasis, and development. Although GR is expressed in nearly every cell type, its activity is tissu…
View article: Hypoxia-induced epigenetic regulation of breast cancer progression and the tumour microenvironment
Hypoxia-induced epigenetic regulation of breast cancer progression and the tumour microenvironment Open
Graphical Abstract Hypoxia-mediated epigenetic regulation of breast cancer progression.
View article: ZMIZ1 enhances ERα-dependent expression of E2F2 in breast cancer
ZMIZ1 enhances ERα-dependent expression of E2F2 in breast cancer Open
The estrogen receptor-α (ER) drives 75% of breast cancers. On activation, the ER recruits and assembles a 1–2 MDa transcriptionally active complex. These complexes can modulate tumour growth, and understanding the roles of individual prote…
View article: A Human Breast Cell Atlas Mapping the Homeostatic Cellular Shifts in the Adult Breast
A Human Breast Cell Atlas Mapping the Homeostatic Cellular Shifts in the Adult Breast Open
One of the barriers for breast cancer prevention and treatment is our poor understanding of the dynamic cellular shifts that naturally occur within the breast and how these changes contribute to tumour initiation. In this study we report t…
View article: In Breast Cancer ZMIZ1 Co-Regulates E2F2 as Part of the Estrogen Receptor-Mediated Cell-Cycle Response
In Breast Cancer ZMIZ1 Co-Regulates E2F2 as Part of the Estrogen Receptor-Mediated Cell-Cycle Response Open
The Estrogen Receptor (ER) drives 75% of breast cancers. On activation, the ER recruits co-factors to form a transcriptionally active complex. These co-factors can modulate tumour growth, and understanding their roles can help to identify …