Jack W. Sample
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View article: Frequent EPHA2 receptor mutations in cholangiocarcinoma disrupt receptor forward signaling supporting a tumor suppressor role
Frequent EPHA2 receptor mutations in cholangiocarcinoma disrupt receptor forward signaling supporting a tumor suppressor role Open
Although EPHA2 is a receptor tyrosine kinase widely expressed in many cancers, it exhibits a uniquely high frequency of coding sequence mutations in cholangiocarcinoma, a cancer of the biliary tract with dismal prognosis. EPHA2 is extensiv…
View article: Multiomics combined with machine learning defines unique molecular subtypes of cholangiocarcinoma and identifies TNK1 as a therapeutic target
Multiomics combined with machine learning defines unique molecular subtypes of cholangiocarcinoma and identifies TNK1 as a therapeutic target Open
Background and Aims: Cholangiocarcinoma (CCA) is one of the most lethal cancers, characterized by molecular heterogeneity and treatment resistance. To uncover new biological signals and therapeutic opportunities, we employed multiomic char…
View article: Frequent EPHA2 receptor mutations in cholangiocarcinoma disrupt receptor forward signaling supporting a tumor suppressor role
Frequent EPHA2 receptor mutations in cholangiocarcinoma disrupt receptor forward signaling supporting a tumor suppressor role Open
EPHA2 is a receptor tyrosine kinase highly expressed in many cancers. By analyzing cancer patient databases for mutations in the EPHA2 coding sequence, we found that cholangiocarcinoma (a hepatobiliary cancer with dismal prognosis) exhibit…
View article: <scp>YAP</scp> ‐ <scp>TEAD</scp> inhibition is associated with upregulation of an androgen receptor mediated transcription program providing therapeutic escape
<span>YAP</span> ‐ <span>TEAD</span> inhibition is associated with upregulation of an androgen receptor mediated transcription program providing therapeutic escape Open
Cholangiocarcinoma (CCA) is a highly aggressive form of liver cancer and is an increasing cause of cancer‐related death worldwide. Despite its increasing incidence globally and alarming mortality, treatment options for CCA have largely rem…
View article: Rare Complications Following Laparoscopic Sleeve Gastrectomy
Rare Complications Following Laparoscopic Sleeve Gastrectomy Open
Metabolic and bariatric surgery (MBS) is the most effective and durable therapeutic intervention for patients with obesity. In recent years, laparoscopic sleeve gastrectomy (SG) has become the most commonly performed primary MBS procedure …
View article: The Trajectory of Revisional Bariatric Surgery: Open to Laparoscopic to Robotic
The Trajectory of Revisional Bariatric Surgery: Open to Laparoscopic to Robotic Open
Metabolic and bariatric surgery (MBS) is the most effective therapeutic intervention for patients with obesity, with sleeve gastrectomy (SG) being the most commonly performed primary MBS procedure. Long-term studies have demonstrated that …
View article: Preoperative duration of type 2 diabetes mellitus and remission after Roux-en-Y gastric bypass: a single center long-term cohort study
Preoperative duration of type 2 diabetes mellitus and remission after Roux-en-Y gastric bypass: a single center long-term cohort study Open
Background: Roux-en-Y gastric bypass (RYGB) has demonstrated excellent glycemic control and type 2 diabetes mellitus (T2DM) remission for patients with obesity and T2DM. Duration of T2DM is a consistent negative predictor of remission afte…
View article: A Case of Hepatitis B Virus Reactivation Triggered by Acute Epstein-Barr Virus Infection
A Case of Hepatitis B Virus Reactivation Triggered by Acute Epstein-Barr Virus Infection Open
Reactivation ofHepatitis B virus (HBV) is not an uncommon condition. It is known to occur with immunosuppressive therapy. There are several viral infections that can trigger HBV reactivation, such as human immunodeficiency virus (HIV) infe…
View article: Both high fat and high carbohydrate diets impair vagus nerve signaling of satiety
Both high fat and high carbohydrate diets impair vagus nerve signaling of satiety Open
Obesity remains prevalent in the US. One potential treatment is vagus nerve stimulation (VNS), which activates the sensory afferents innervating the stomach that convey stomach volume and establish satiety. However, current VNS approaches …
View article: Replication Data for: "Both high fat and high carbohydrate diets impair vagus nerve signaling of satiety"
Replication Data for: "Both high fat and high carbohydrate diets impair vagus nerve signaling of satiety" Open
Data were obtained during stomach distension in rat that were maintained on standard, high fat, or high carbohydrate diets. The data provide quantification of recordings from the left cervical vagus nerve during stomach distension, along w…
View article: A Rare Complication of Ileus Following Endoscopic Ultrasound-Guided Celiac Plexus Neurolysis: A Case Report
A Rare Complication of Ileus Following Endoscopic Ultrasound-Guided Celiac Plexus Neurolysis: A Case Report Open