Jack M. Webster
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Titanium Meets Carbon: Enhanced Reusable Filters for Oil–Water Separation and Environmental Remediation Open
To mitigate the environmental effects of oil spills, a novel hydrophilic–oleophobic mixed-coated filter was developed for efficient oil–water separation and surface oil recovery. The coating consisted of titanium dioxide nanoparticles (TiO…
View article: <b>Benzothiazole Substitution Analogs of Rhodacyanine Hsp70 Inhibitors Modulate Tau Accumulation</b>
<b>Benzothiazole Substitution Analogs of Rhodacyanine Hsp70 Inhibitors Modulate Tau Accumulation</b> Open
The accumulation and aggregation of the microtubule-associated protein tau (tau) into intracellular neuronal tangles are a hallmark of a range of progressive neurodegenerative tauopathies, including Alzheimer's disease (AD), frontotemporal…
View article: Hsp22 with an N-Terminal Domain Truncation Mediates a Reduction in Tau Protein Levels
Hsp22 with an N-Terminal Domain Truncation Mediates a Reduction in Tau Protein Levels Open
Misfolding, aggregation and accumulation of proteins are toxic elements in the progression of a broad range of neurodegenerative diseases. Molecular chaperones enable a cellular defense by reducing or compartmentalizing these insults. Smal…
Small Heat Shock Proteins, Big Impact on Protein Aggregation in Neurodegenerative Disease Open
Misfolding, aggregation, and aberrant accumulation of proteins are central components in the progression of neurodegenerative disease. Cellular molecular chaperone systems modulate proteostasis, and, therefore, are primed to influence aber…
View article: Hsp90 activator Aha1 drives production of pathological tau aggregates
Hsp90 activator Aha1 drives production of pathological tau aggregates Open
Significance The accumulation of toxic tau protein, as in Alzheimer’s disease, is regulated by the 90-kDa heat shock protein (Hsp90) chaperone system. Inhibition of Hsp90 has been shown to reduce tau levels. However, Hsp90 inhibition can b…
<sup>18</sup>F-5-Fluoroaminosuberic Acid as a Potential Tracer to Gauge Oxidative Stress in Breast Cancer Models Open
The cystine transporter (system xC-) is an antiporter of cystine and glutamate. It has relatively low basal expression in most tissues and becomes upregulated in cells under oxidative stress (OS) as one of the genes expressed in response t…