Han Wang
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View article: Characterization and predictive value of lymphocyte subsets in peripheral blood of patients with colorectal cancer
Characterization and predictive value of lymphocyte subsets in peripheral blood of patients with colorectal cancer Open
Purpose: Cellular immune response to cancer is known to be of great importance for tumor control. Until now, the role of systemic immune profiles in tumor progression remains unclear. Methods: By using multiparameter flow cytometry, the su…
View article: Comparative transcriptome analysis reveals abscisic acid-induced bHLH transcription factors involved in saikosaponin biosynthesis in <i>Bupleurum chinense</i> DC
Comparative transcriptome analysis reveals abscisic acid-induced bHLH transcription factors involved in saikosaponin biosynthesis in <i>Bupleurum chinense</i> DC Open
Bupleurum chinense DC. a medicinal plant valued for saikosaponins (SSs) with antipyretic and hepatoprotective properties, faces constrained SS biosynthesis mediated by abscisic acid (ABA) during growth. Basic helix-loop-helix (bHLH) transc…
View article: GABRD Accelerates Tumour Progression via Regulating CCND1 Signalling Pathway in Gastric Cancer
GABRD Accelerates Tumour Progression via Regulating CCND1 Signalling Pathway in Gastric Cancer Open
Neurotransmitters and their receptors were reported to be involved in tumour initiation and progression. However, little is known about their roles in gastric cancer (GC). Here, we first identified gamma‐aminobutyric acid type A receptor s…
View article: Compression force regulates cementoblast mineralization via <scp>S1PR1</scp> /mitophagy axis
Compression force regulates cementoblast mineralization via <span>S1PR1</span> /mitophagy axis Open
Orthodontically induced inflammatory root resorption (OIIRR) poses a significant clinical challenge, as excessive orthodontic force shortens tooth longevity by impairing cementoblast‐mediated cementum mineralization and promoting root reso…
View article: The OpenLAM Challenges
The OpenLAM Challenges Open
Inspired by the success of Large Language Models (LLMs), the development of Large Atom Models (LAMs) has gained significant momentum in scientific computation. Since 2022, the Deep Potential team has been actively pretraining LAMs and laun…
View article: Telomere length and micronuclei trajectories in <scp>APP</scp>/<scp>PS1</scp> mouse model of Alzheimer's disease: Correlating with cognitive impairment and brain amyloidosis in a sexually dimorphic manner
Telomere length and micronuclei trajectories in <span>APP</span>/<span>PS1</span> mouse model of Alzheimer's disease: Correlating with cognitive impairment and brain amyloidosis in a sexually dimorphic manner Open
Although studies have demonstrated that genome instability is accumulated in patients with Alzheimer's disease (AD), the specific types of genome instability linked to AD pathogenesis remain poorly understood. Here, we report the first cha…
View article: Long non‐coding <scp>RNA LncTUG1</scp> regulates favourable compression force‐induced cementocytes mineralization via <scp>PU</scp>.1/<scp>TLR4</scp>/<scp>SphK1</scp> signalling
Long non‐coding <span>RNA LncTUG1</span> regulates favourable compression force‐induced cementocytes mineralization via <span>PU</span>.1/<span>TLR4</span>/<span>SphK1</span> signalling Open
Orthodontic tooth movement (OTM) is a highly coordinated biomechanical response to orthodontic forces with active remodelling of alveolar bone but minor root resorption. Such antiresorptive properties of root relate to cementocyte minerali…
View article: The onset of adenosine monophosphate‐activated protein kinase activity on orthodontic tooth movement in rats with type 2 diabetes
The onset of adenosine monophosphate‐activated protein kinase activity on orthodontic tooth movement in rats with type 2 diabetes Open
Adenosine monophosphate‐activated protein kinase (AMPK) plays pivotal roles in metabolic diseases including type 2 diabetes. However, the specific role of AMPK for orthodontic tooth movement in type 2 diabetes is unclear. In this study, a …
View article: Comprehensive prognostic signatures in thyroid cancer: A summarized review for molecular signatures construction strategies
Comprehensive prognostic signatures in thyroid cancer: A summarized review for molecular signatures construction strategies Open
Thyroid carcinoma (TC) is one of the most common endocrine carcinomas with an increasing rate of morbidity in recent decades. With a high risk of relapse and metastasis occurring in TC patients, it is essential to identify potential progno…
View article: Identification of quiescent FOXC2+ spermatogonial stem cells in adult mammals
Identification of quiescent FOXC2+ spermatogonial stem cells in adult mammals Open
In adult mammals, spermatogenesis embodies the complex developmental process from spermatogonial stem cells (SSCs) to spermatozoa. At the top of this developmental hierarchy lie a series of SSC subpopulations. Their individual identities a…
View article: Ependymin‐related protein 1 levels are elevated in children with obesity and correlated with metabolic disorders
Ependymin‐related protein 1 levels are elevated in children with obesity and correlated with metabolic disorders Open
Ependymin‐related protein 1 (EPDR1) has been found in the secretory body of adipocytes where it plays a role in lipid binding, transportation, and catabolism. The aim of this study was to investigate serum EPDR1 levels in children with obe…
View article: PUM1 Promotes Tumor Progression by Activating DEPTOR‐Meditated Glycolysis in Gastric Cancer
PUM1 Promotes Tumor Progression by Activating DEPTOR‐Meditated Glycolysis in Gastric Cancer Open
RNA‐binding proteins (RBPs) play essential roles in tumorigenesis and progression, but their functions in gastric cancer (GC) remain largely elusive. Here, it is reported that Pumilio 1 (PUM1), an RBP, induces metabolic reprogramming throu…
View article: Author Response: Identification of quiescent FOXC2+ spermatogonial stem cells in adult mammals
Author Response: Identification of quiescent FOXC2+ spermatogonial stem cells in adult mammals Open
In adult mammals, spermatogenesis embodies the complex developmental process from spermatogonial stem cells (SSCs) to spermatozoa. At the top of this developmental hierarchy lie a series of SSC subpopulations. Their individual identities a…
View article: Identification of quiescent FOXC2+ spermatogonial stem cells in adult mammals
Identification of quiescent FOXC2+ spermatogonial stem cells in adult mammals Open
In adult mammals, spermatogenesis embodies the complex developmental process from spermatogonial stem cells (SSCs) to spermatozoa. At the top of this developmental hierarchy lie a series of SSC subpopulations. Their individual identities a…
View article: Effects of folate on telomere length and chromosome stability of human fibroblasts and melanoma cells <i>in vitro</i>: a comparison of folic acid and 5-methyltetrahydrofolate
Effects of folate on telomere length and chromosome stability of human fibroblasts and melanoma cells <i>in vitro</i>: a comparison of folic acid and 5-methyltetrahydrofolate Open
Telomere length (TL), which is maintained by human telomerase reverse transcriptase (hTERT; component of telomerase) and/or TRF1/TRF2 (core components of shelterin) via different mechanisms, is essential for chromosomal stability and cell …
View article: FOXC2 marks and maintains the primitive spermatogonial stem cells subpopulation in the adult testis
FOXC2 marks and maintains the primitive spermatogonial stem cells subpopulation in the adult testis Open
In adult mammals, spermatogenesis embodies the complex transition from spermatogonial stem cells (SSCs) to spermatozoa. This process is initiated by the dynamic transition among a series of SSCs subpopulations. However, it remains elusive …
View article: Identification of quiescent FOXC2+ spermatogonial stem cells in adult mammals
Identification of quiescent FOXC2+ spermatogonial stem cells in adult mammals Open
In adult mammals, spermatogenesis embodies the complex developmental process from spermatogonial stem cells (SSCs) to spermatozoa. At the top of this developmental hierarchy lie a series of SSC subpopulations. Their individual identities a…
View article: Molecular Mechanism of Long Noncoding RNA SNHG14 in Osteogenic Differentiation of Bone Marrow-Derived Mesenchymal Stem Cells through the NEDD4L/FOXA2/PCP4 Axis
Molecular Mechanism of Long Noncoding RNA SNHG14 in Osteogenic Differentiation of Bone Marrow-Derived Mesenchymal Stem Cells through the NEDD4L/FOXA2/PCP4 Axis Open
Bone marrow-derived mesenchymal stem cells (BMSCs) have a superior potential of osteogenic differentiation (OD) and a promising stem cell type to treat bone defects. This study sought to investigate the molecular mechanism of long noncodin…
View article: Mitochondrial Dynamics: Working with the Cytoskeleton and Intracellular Organelles to Mediate Mechanotransduction
Mitochondrial Dynamics: Working with the Cytoskeleton and Intracellular Organelles to Mediate Mechanotransduction Open
Cells are constantly exposed to various mechanical environments; therefore, it is important that they are able to sense and adapt to changes. It is known that the cytoskeleton plays a critical role in mediating and generating extra- and in…
View article: Identification of quiescent FOXC2 <sup>+</sup> spermatogonial stem cells in adult mammals
Identification of quiescent FOXC2 <sup>+</sup> spermatogonial stem cells in adult mammals Open
In adult mammals, spermatogenesis embodies the complex developmental process from spermatogonial stem cells (SSCs) to spermatozoa. At the top of this developmental hierarchy lie a series of SSC subpopulations. Their individual identities a…
View article: Efficacy and Safety of Low-Dose Interleukin 2 for Primary Sjögren Syndrome
Efficacy and Safety of Low-Dose Interleukin 2 for Primary Sjögren Syndrome Open
Importance Primary Sjögren syndrome (pSS) is a systemic autoimmune disease associated with dysregulated immune cells, with no efficient therapy. There is a need to study potential therapeutic approaches. Objective To investigate the effica…
View article: Inositol Derivatives with Anti-Inflammatory Activity from Leaves of Solanum capsicoides Allioni
Inositol Derivatives with Anti-Inflammatory Activity from Leaves of Solanum capsicoides Allioni Open
Eight new inositol derivatives, solsurinositols A–H (1–8), were isolated from the 70% EtOH extract of the leaves of Solanum capsicoides Allioni. Careful isolation by silica gel column chromatography followed by preparative high-performance…