Jackie F. Price
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View article: Untargeted Proteomic Profiling Identifies Candidate Biomarkers for Early Detection of Cardiovascular Disease and Mortality
Untargeted Proteomic Profiling Identifies Candidate Biomarkers for Early Detection of Cardiovascular Disease and Mortality Open
Background The serum proteome can provide valuable insights into the development and progression of diseases. This is particularly important for cardiovascular disease (CVD), a leading cause of death worldwide. In this large-scale cohort s…
View article: Mechanisms by which phytogenic extracts enhance livestock reproductive health: current insights and future directions
Mechanisms by which phytogenic extracts enhance livestock reproductive health: current insights and future directions Open
Reproductive health is a critical determinant of livestock productivity and economic sustainability. However, it is often compromised by infectious diseases, environmental stressors, and nutritional deficits. Phytogenic extracts—bioactive …
View article: A blood- and brain-based EWAS of smoking
A blood- and brain-based EWAS of smoking Open
DNA methylation offers an objective method to assess the impact of smoking. In this work, we conduct a Bayesian EWAS of smoking pack years ( n = 17,865, ~850k sites, Illumina EPIC array) and extend it by analysing whole genome data of smok…
View article: Multiple Long‐Term Conditions, Co‐Long‐Term Conditions and Polyvascular Disease: Considerations for Evidence Synthesis and Meta‐Analyses
Multiple Long‐Term Conditions, Co‐Long‐Term Conditions and Polyvascular Disease: Considerations for Evidence Synthesis and Meta‐Analyses Open
Cochrane's scientific strategy for 2025 to 2030 has four research priorities, including improving the lives of people living with multiple chronic conditions. The purpose of this article written by the Cochrane Thematic Group in Heart, Str…
View article: A blood- and brain-based EWAS of smoking
A blood- and brain-based EWAS of smoking Open
DNA methylation offers an objective method to assess the impact of smoking. In this work, we conduct a Bayesian EWAS of smoking pack years (n=17,865, ∼850k sites, Illumina EPIC array) and extend it by analysing whole genome data of smokers…
View article: Cholesteryl ester transfer protein (CETP) as a drug target for cardiovascular disease
Cholesteryl ester transfer protein (CETP) as a drug target for cardiovascular disease Open
Development of cholesteryl ester transfer protein (CETP) inhibitors for coronary heart disease (CHD) has yet to deliver licensed medicines. To distinguish compound from drug target failure, we compared evidence from clinical trials and dru…
View article: GWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes
GWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes Open
Carotid artery intima media thickness (cIMT) and carotid plaque are measures of subclinical atherosclerosis associated with ischemic stroke and coronary heart disease (CHD). Here, we undertake meta-analyses of genome-wide association studi…
View article: Epigenetic Contributions to Clinical Risk Prediction of Cardiovascular Disease
Epigenetic Contributions to Clinical Risk Prediction of Cardiovascular Disease Open
BACKGROUND: Cardiovascular disease (CVD) is among the leading causes of death worldwide. The discovery of new omics biomarkers could help to improve risk stratification algorithms and expand our understanding of molecular pathways contribu…
View article: Exploration of Metabolomic Markers Associated With Declining Kidney Function in People With Type 2 Diabetes Mellitus
Exploration of Metabolomic Markers Associated With Declining Kidney Function in People With Type 2 Diabetes Mellitus Open
Background Metabolomics, the study of small molecules in biological systems, can provide valuable insights into kidney dysfunction in people with type 2 diabetes mellitus (T2DM), but prospective studies are scarce. We investigated the asso…
View article: Predictive metabolites for incident myocardial infarction: a two-step meta-analysis of individual patient data from six cohorts comprising 7897 individuals from the COnsortium of METabolomics Studies
Predictive metabolites for incident myocardial infarction: a two-step meta-analysis of individual patient data from six cohorts comprising 7897 individuals from the COnsortium of METabolomics Studies Open
Aims Myocardial infarction (MI) is a major cause of death and disability worldwide. Most metabolomics studies investigating metabolites predicting MI are limited by the participant number and/or the demographic diversity. We sought to iden…
View article: Life expectancy associated with different ages at diagnosis of type 2 diabetes in high-income countries: 23 million person-years of observation
Life expectancy associated with different ages at diagnosis of type 2 diabetes in high-income countries: 23 million person-years of observation Open
View article: Triangulating evidence from observational and Mendelian randomization studies of ketone bodies for cognitive performance
Triangulating evidence from observational and Mendelian randomization studies of ketone bodies for cognitive performance Open
Background Ketone bodies (KBs) are an alternative energy supply for brain functions when glucose is limited. The most abundant ketone metabolite, 3-β-hydroxybutyrate (BOHBUT), has been suggested to prevent or delay cognitive impairment, bu…
View article: Combining serum metabolomic profiles with traditional risk factors improves 10-year cardiovascular risk prediction in people with type 2 diabetes
Combining serum metabolomic profiles with traditional risk factors improves 10-year cardiovascular risk prediction in people with type 2 diabetes Open
Aims To identify a group of metabolites associated with incident cardiovascular disease (CVD) in people with type 2 diabetes and assess its predictive performance over-and-above a current CVD risk score (QRISK3). Methods and results A pane…
View article: Risk of dementia associated with body mass index, changes in body weight and waist circumference in older people with type 2 diabetes: The Edinburgh Type 2 Diabetes Study
Risk of dementia associated with body mass index, changes in body weight and waist circumference in older people with type 2 diabetes: The Edinburgh Type 2 Diabetes Study Open
Aims/Hypothesis To determine the relationship of dementia with preceding body mass index (BMI), changes in body weight and waist circumference in older people with type 2 diabetes. Methods In the Edinburgh Type 2 Diabetes Study (1064 men a…
View article: Biomedical consequences of elevated cholesterol-containing lipoproteins and apolipoproteins on cardiovascular and non-cardiovascular outcomes
Biomedical consequences of elevated cholesterol-containing lipoproteins and apolipoproteins on cardiovascular and non-cardiovascular outcomes Open
View article: Epigenetic contributions to clinical risk prediction of cardiovascular disease
Epigenetic contributions to clinical risk prediction of cardiovascular disease Open
Background and Aims Cardiovascular disease (CVD) is among the leading causes of death worldwide. Discovery of new omics biomarkers could help to improve risk stratification algorithms and expand our understanding of molecular pathways cont…
View article: Higher Arm Versus Lower Arm Systolic Blood Pressure and Cardiovascular Outcomes: a Meta-Analysis of Individual Participant Data From the INTERPRESS-IPD Collaboration
Higher Arm Versus Lower Arm Systolic Blood Pressure and Cardiovascular Outcomes: a Meta-Analysis of Individual Participant Data From the INTERPRESS-IPD Collaboration Open
BACKGROUND: Guidelines recommend measuring blood pressure (BP) in both arms, adopting the higher arm readings for diagnosis and management. Data to support this recommendation are lacking. We evaluated associations of higher and lower arm …
View article: Biomedical consequences of elevated cholesterol-containing lipoproteins and apolipoproteins
Biomedical consequences of elevated cholesterol-containing lipoproteins and apolipoproteins Open
Aims To provide a comprehensive evaluation of the biomedical effects of circulating concentrations of cholesterol-containing lipoproteins and apolipoproteins. Methods and Results Nuclear magnetic resonance (NMR) spectroscopy was used to me…
View article: Association of functional health literacy and cognitive ability with self-reported diabetes in the English Longitudinal Study of Ageing: a prospective cohort study
Association of functional health literacy and cognitive ability with self-reported diabetes in the English Longitudinal Study of Ageing: a prospective cohort study Open
Objectives We investigated whether functional health literacy and cognitive ability were associated with self-reported diabetes. Design Prospective cohort study. Setting Data were from waves 2 (2004–2005) to 7 (2014–2015) of the English Lo…
View article: Serum metabolomic profiles associated with subclinical and clinical cardiovascular phenotypes in people with type 2 diabetes
Serum metabolomic profiles associated with subclinical and clinical cardiovascular phenotypes in people with type 2 diabetes Open
View article: Biomedical consequences of elevated cholesterol-containing lipoproteins and apolipoproteins
Biomedical consequences of elevated cholesterol-containing lipoproteins and apolipoproteins Open
Aims To provide a comprehensive evaluation of the biomedical effects of circulating concentrations of cholesterol-containing lipoproteins and apolipoproteins. Methods and Results Nuclear magnetic resonance (NMR) spectroscopy was used to me…
View article: Higher baseline inflammatory marker levels predict greater cognitive decline in older people with type 2 diabetes: year 10 follow-up of the Edinburgh Type 2 Diabetes Study
Higher baseline inflammatory marker levels predict greater cognitive decline in older people with type 2 diabetes: year 10 follow-up of the Edinburgh Type 2 Diabetes Study Open
View article: Validation of lipid-related therapeutic targets for coronary heart disease prevention using human genetics
Validation of lipid-related therapeutic targets for coronary heart disease prevention using human genetics Open
View article: Genome-Wide Association Study of Peripheral Artery Disease
Genome-Wide Association Study of Peripheral Artery Disease Open
Background: Peripheral artery disease (PAD) affects >200 million people worldwide and is associated with high mortality and morbidity. We sought to identify genomic variants associated with PAD overall and in the contexts of diabetes and s…
View article: Cholesteryl ester transfer protein (CETP) as a drug target for cardiovascular disease
Cholesteryl ester transfer protein (CETP) as a drug target for cardiovascular disease Open
View article: Association of Cardiometabolic Multimorbidity With Mortality
Association of Cardiometabolic Multimorbidity With Mortality Open
The prevalence of cardiometabolic multimorbidity is increasing.
View article: Retinal arteriolar tortuosity and fractal dimension are associated with long-term cardiovascular outcomes in people with type 2 diabetes
Retinal arteriolar tortuosity and fractal dimension are associated with long-term cardiovascular outcomes in people with type 2 diabetes Open
Aims/hypothesis Our aim was to determine whether quantitative retinal traits in people with type 2 diabetes are independently associated with incident major cardiovascular events including CHD and stroke. Methods A total of 1066 men and wo…
View article: Addition of hyaluronic acid to the FIB‐4 liver fibrosis score improves prediction of incident cirrhosis and hepatocellular carcinoma in type 2 diabetes: The Edinburgh Type 2 Diabetes Study
Addition of hyaluronic acid to the FIB‐4 liver fibrosis score improves prediction of incident cirrhosis and hepatocellular carcinoma in type 2 diabetes: The Edinburgh Type 2 Diabetes Study Open
Background Type 2 diabetes (T2D) is associated with increased risk of progression to cirrhosis and hepatocellular carcinoma (HCC) in people with chronic liver diseases, particularly non‐alcoholic fatty liver disease (NAFLD). However, the a…
View article: Retinal venular tortuosity and fractal dimension predict incident retinopathy in adults with type 2 diabetes: the Edinburgh Type 2 Diabetes Study
Retinal venular tortuosity and fractal dimension predict incident retinopathy in adults with type 2 diabetes: the Edinburgh Type 2 Diabetes Study Open
View article: Variation in the SERPINA6/SERPINA1 locus alters morning plasma cortisol, hepatic corticosteroid binding globulin expression, gene expression in peripheral tissues, and risk of cardiovascular disease
Variation in the SERPINA6/SERPINA1 locus alters morning plasma cortisol, hepatic corticosteroid binding globulin expression, gene expression in peripheral tissues, and risk of cardiovascular disease Open