Jennifer Ma
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View article: Role of Endoscopy in the Diagnosis and Management of Esophageal Cancer
Role of Endoscopy in the Diagnosis and Management of Esophageal Cancer Open
Esophageal cancer cases are predicted to reach 957,000 by 2040. Prior mortality rates average 6.5% in men and 2.2% in women, with a poor 5-year prognosis of 20%. A deficiency in screening guidelines, an incomplete understanding of pathophy…
View article: Thymus Composition Predicts Pneumonitis Risk in Lung Cancer Therapy
Thymus Composition Predicts Pneumonitis Risk in Lung Cancer Therapy Open
Background Durvalumab consolidation after concurrent chemoradiotherapy (cCRT) is the standard-of-care for unresectable stage III non–small cell lung cancer (NSCLC) without actionable driver mutations. However, pneumonitis remains a dose-li…
View article: Updated Estimates of Patients With Oropharyngeal Cancer in the US
Updated Estimates of Patients With Oropharyngeal Cancer in the US Open
Importance Updated estimates of oropharyngeal cancer (OPC) in the US are needed. Objective To calculate the most recent epidemiologic estimates of OPC in the US and provide projections for future trends up to 2040. Design, Setting, and Par…
View article: Thymus Composition, Disease Control, and Toxicity in Locally Advanced Lung Cancer
Thymus Composition, Disease Control, and Toxicity in Locally Advanced Lung Cancer Open
Thymic involution, characterized by adipose replacement of functional thymic tissue, is a broadly recognized feature of age-related immunosenescence. Currently, no established, non-invasive method measures residual thymus in adults, its re…
View article: Prospective validation of a pretreatment 18F-FDG PET/CT and mean lung dose model for early radiation pneumonitis
Prospective validation of a pretreatment 18F-FDG PET/CT and mean lung dose model for early radiation pneumonitis Open
The previously developed SUVP90 and MLD-based risk model for RPEarly demonstrated a high probability to correctly predict RPEarly in the independent cohort. This now validated RPEarly risk model with derived high-risk indications could ena…
View article: Comparison of six COVID-19 serology assays for detection of antibodies from patients infected with ancestral and a spectrum of SARS-CoV-2 variants
Comparison of six COVID-19 serology assays for detection of antibodies from patients infected with ancestral and a spectrum of SARS-CoV-2 variants Open
Serology assays against spike, receptor binding domain (RBD) and nucleocapsid proteins of the severe acute respiratory syndrome coronavirus 2 are essential for serosurveillance. We performed a comparison of four medium-to-high throughput c…
View article: The cold immunological landscape of ATM-deficient cancers
The cold immunological landscape of ATM-deficient cancers Open
Background Mutations in genes encoding DNA repair factors, which facilitate mismatch repair, homologous recombination, or DNA polymerase functions, are known to enhance tumor immunogenicity. Ataxia telangiectasia mutated ( ATM ) is a centr…
View article: Management approaches for primary hepatic lymphoma: 10 year institutional experience with comprehensive literature review
Management approaches for primary hepatic lymphoma: 10 year institutional experience with comprehensive literature review Open
Purpose/objective: Primary hepatic lymphomas (PHL) are an extremely rare form of non-Hodgkin Lymphoma (NHL) for which there are no established treatment guidelines, with available literature largely comprised of small case reports. Therefo…
View article: Management approaches for primary hepatic lymphoma: 10 year institutional experience with comprehensive literature review
Management approaches for primary hepatic lymphoma: 10 year institutional experience with comprehensive literature review Open
Purpose/objective Primary hepatic lymphomas (PHL) are an extremely rare form of non-Hodgkin Lymphoma (NHL) for which there are no established treatment guidelines, with available literature largely comprised of small case reports. Therefor…
View article: Supplementary Figures 1 from Genotype-Directed Synthetic Cytotoxicity of ATR Inhibition with Radiotherapy
Supplementary Figures 1 from Genotype-Directed Synthetic Cytotoxicity of ATR Inhibition with Radiotherapy Open
Supplementary Figures
View article: Data from Genotype-Directed Synthetic Cytotoxicity of ATR Inhibition with Radiotherapy
Data from Genotype-Directed Synthetic Cytotoxicity of ATR Inhibition with Radiotherapy Open
Purpose:The importance of the DNA damage response in mediating effects of radiotherapy (RT) has galvanized efforts to target this pathway with radiosensitizers. Yet early clinical trials of this approach have failed to yield a benefit in u…
View article: Large-scale copy number alterations are enriched for synthetic viability in BRCA1/BRCA2 tumors
Large-scale copy number alterations are enriched for synthetic viability in BRCA1/BRCA2 tumors Open
Background Pathogenic BRCA1 or BRCA2 germline mutations contribute to hereditary breast, ovarian, prostate, and pancreatic cancer. Paradoxically, bi-allelic inactivation of BRCA1 or BRCA2 (bBRCA1/2) is embryonically lethal and decreases ce…
View article: Genotype-Directed Synthetic Cytotoxicity of ATR Inhibition with Radiotherapy
Genotype-Directed Synthetic Cytotoxicity of ATR Inhibition with Radiotherapy Open
Purpose: The importance of the DNA damage response in mediating effects of radiotherapy (RT) has galvanized efforts to target this pathway with radiosensitizers. Yet early clinical trials of this approach have failed to yield a benefit in …
View article: Artificial-intelligence-driven measurements of brain metastases’ response to SRS compare favorably with current manual standards of assessment
Artificial-intelligence-driven measurements of brain metastases’ response to SRS compare favorably with current manual standards of assessment Open
Background Evaluation of treatment response for brain metastases (BMs) following stereotactic radiosurgery (SRS) becomes complex as the number of treated BMs increases. This study uses artificial intelligence (AI) to track BMs after SRS an…
View article: Radiation and Immune Checkpoint Inhibitors: Combination Therapy for Treatment of Hepatocellular Carcinoma
Radiation and Immune Checkpoint Inhibitors: Combination Therapy for Treatment of Hepatocellular Carcinoma Open
The liver tumor immune microenvironment has been thought to possess a critical role in the development and progression of hepatocellular carcinoma (HCC). Despite the approval of immune checkpoint inhibitors (ICIs), such as programmed cell …
View article: Recent Patterns of Radiotherapy Use in Multiple Myeloma: Clinical Outcomes and Possible Radiologic, Biochemical, and Genomic Correlates of Response
Recent Patterns of Radiotherapy Use in Multiple Myeloma: Clinical Outcomes and Possible Radiologic, Biochemical, and Genomic Correlates of Response Open
Background/Objectives: Systemic therapies for multiple myeloma (MM) have advanced considerably, changing the landscape of MM treatment paradigms. Yet, the use of radiotherapy (RT) has remained heterogeneous, and even controversial, due to …
View article: EPCO-01. THE GENOMIC LANDSCAPE OF BRAIN METASTASIS
EPCO-01. THE GENOMIC LANDSCAPE OF BRAIN METASTASIS Open
BACKGROUND The prognosis for patients with brain metastasis (BM) is devastating, while the underlying biology of BM development remains poorly understood. Identification of genomic biomarkers can offer promising opportunities for predictio…
View article: Radiotherapy as an effective bridge for chemo‐refractory or progressive secondary CNS lymphoma
Radiotherapy as an effective bridge for chemo‐refractory or progressive secondary CNS lymphoma Open
Introduction: Secondary CNS lymphoma (SCNSL) is observed in 2%–5% of patients with diffuse large B cell lymphoma (DLBCL). Progression of SCNSL after first line CNS-directed systemic therapy is particularly challenging, without clear standa…
View article: Genomic Correlates of Radiosensitivity in Diffuse Large B Cell Lymphoma
Genomic Correlates of Radiosensitivity in Diffuse Large B Cell Lymphoma Open
Introduction: Radiotherapy (RT) is beneficial for select patients with localized diffuse large B cell lymphoma (DLBCL), in both early stage and in relapsed/refractory settings. Genomic predictors of local response to RT have yet to be adeq…
View article: Radiation in a new era of Multiple Myeloma management: Patterns of utilization, clinical, radiologic, and biochemical outcomes, and possible genomic correlates of response
Radiation in a new era of Multiple Myeloma management: Patterns of utilization, clinical, radiologic, and biochemical outcomes, and possible genomic correlates of response Open
Background/Objectives: Systemic therapies for multiple myeloma (MM) have advanced considerably, improving patient outcomes. Yet, the use of radiotherapy (RT) has remained heterogeneous, and even controversial, due to minimal data on outcom…
View article: Genetic Alterations in Follicular Lymphoma Predict Response to Very Low Dose Radiotherapy
Genetic Alterations in Follicular Lymphoma Predict Response to Very Low Dose Radiotherapy Open
Introduction: Follicular lymphoma (FL) is typically indolent, but relapses and transformation to higher grade disease are common. FL is often sensitive to radiotherapy (RT) and can show a complete response (CR) even to very low dose radiot…
View article: PRIMARY HEPATIC LYMPHOMA: ROLE OF LOW‐DOSE RADIOTHERAPY AND PAIRED LITERATURE REVIEW
PRIMARY HEPATIC LYMPHOMA: ROLE OF LOW‐DOSE RADIOTHERAPY AND PAIRED LITERATURE REVIEW Open
Introduction: Primary hepatic lymphomas (PHL) are a rare form of non-Hodgkin lymphoma for which there are no established treatment guidelines. Available literature is largely comprised of small case reports and there are no reports on low-…
View article: Table 1 from <i>ERCC2</i> Helicase Domain Mutations Confer Nucleotide Excision Repair Deficiency and Drive Cisplatin Sensitivity in Muscle-Invasive Bladder Cancer
Table 1 from <i>ERCC2</i> Helicase Domain Mutations Confer Nucleotide Excision Repair Deficiency and Drive Cisplatin Sensitivity in Muscle-Invasive Bladder Cancer Open
Table 1
View article: Data from Talazoparib Is a Potent Radiosensitizer in Small Cell Lung Cancer Cell Lines and Xenografts
Data from Talazoparib Is a Potent Radiosensitizer in Small Cell Lung Cancer Cell Lines and Xenografts Open
Purpose: Small cell lung cancer (SCLC) is an aggressive malignancy with a critical need for novel therapies. Our goal was to determine whether PARP inhibition could sensitize SCLC cells to ionizing radiation (IR) and if so, to determine th…
View article: Table 1 from <i>ERCC2</i> Helicase Domain Mutations Confer Nucleotide Excision Repair Deficiency and Drive Cisplatin Sensitivity in Muscle-Invasive Bladder Cancer
Table 1 from <i>ERCC2</i> Helicase Domain Mutations Confer Nucleotide Excision Repair Deficiency and Drive Cisplatin Sensitivity in Muscle-Invasive Bladder Cancer Open
Table 1