Jackson Colson
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View article: Time-restricted feeding reduces cardiovascular disease risk in obese mice
Time-restricted feeding reduces cardiovascular disease risk in obese mice Open
Disrupted feeding and fasting cycles as well as chronic high-fat diet-induced (HFD-induced) obesity are associated with cardiovascular disease risk factors. We designed studies that determined whether 2 weeks of time-restricted feeding (TR…
View article: Aryl Hydrocarbon Receptor Activation Promotes Effector CD4+ T Cell Homeostasis and Restrains Salt-Sensitive Hypertension
Aryl Hydrocarbon Receptor Activation Promotes Effector CD4+ T Cell Homeostasis and Restrains Salt-Sensitive Hypertension Open
Excess dietary salt and salt-sensitivity contribute to cardiovascular disease. Distinct T cell phenotypic responses to high salt and hypertension, as well as influences from environmental cues, are not well understood. The aryl hydrocarbon…
View article: Enhanced vasoconstriction in sickle cell disease is dependent on ETA receptor activation
Enhanced vasoconstriction in sickle cell disease is dependent on ETA receptor activation Open
Sickle cell disease (SCD) carries a significant risk for poor vascular health and vascular dysfunction. High levels of vascular reactive oxygen species (ROS) as well as elevated plasma endothelin-1 (ET-1), a potent vasoconstrictor with act…
View article: Time restricted feeding in diet induced obesity restores diurnal T cell rhythms in the small intestine
Time restricted feeding in diet induced obesity restores diurnal T cell rhythms in the small intestine Open
Diet induced obesity (DIO) causes circadian disruption and dysregulation of T cells in the gut. Previous studies have also shown that immune cells, including T cells, have rhythms of migration through tissues. We previously found that time…
View article: 430 Time restricted feeding in diet induced obesity mouse model reduces aortic stiffness and inflammatory T cells
430 Time restricted feeding in diet induced obesity mouse model reduces aortic stiffness and inflammatory T cells Open
OBJECTIVES/GOALS: Time restricted feeding (TRF) in diet induced obesity (DIO) has several health benefits, including improved metabolic rhythms and inflammation. Our lab has shown that TRF in DIO significantly reduces renal and aortic dama…
View article: Early life stress induces dysregulation of the heme pathway in adult mice
Early life stress induces dysregulation of the heme pathway in adult mice Open
Early life stress (ELS) is associated with cardiovascular disease (CVD) risk in adulthood, but the underlying vascular mechanisms are poorly understood. Increased hemoglobin and heme have recently been implicated to mediate endothelial dys…
View article: Early life stress in mice alters gut microbiota independent of maternal microbiota inheritance
Early life stress in mice alters gut microbiota independent of maternal microbiota inheritance Open
Exposure to early life stress (ELS) is associated with a greater risk of chronic disease development including depression and cardiovascular disease. Altered gut microbiota has been linked to both depression and cardiovascular disease in m…
View article: Timing of Food Intake Drives the Circadian Rhythm of Blood Pressure
Timing of Food Intake Drives the Circadian Rhythm of Blood Pressure Open
Timing of food intake has become a critical factor in determining overall cardiometabolic health. We hypothesized that timing of food intake entrains circadian rhythms of blood pressure (BP) and renal excretion in mice. Male C57BL/6J mice …
View article: Fluid-electrolyte homeostasis requires histone deacetylase function
Fluid-electrolyte homeostasis requires histone deacetylase function Open
Histone deacetylase (HDAC) enzymes regulate transcription through epigenetic modification of chromatin structure, but their specific functions in the kidney remain elusive. We discovered that the human kidney expresses class I HDACs. Kidne…