Jackson Orem
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View article: Impact of Waiting Time and Treatment Duration on Short-Term Outcomes for Patients With Locally Advanced Cervical Cancer at the Uganda Cancer Institute: The Challenges in Resource-Limited Settings
Impact of Waiting Time and Treatment Duration on Short-Term Outcomes for Patients With Locally Advanced Cervical Cancer at the Uganda Cancer Institute: The Challenges in Resource-Limited Settings Open
PURPOSE Cervical cancer remains a significant public health burden, especially in sub-Saharan Africa. The waiting time and treatment duration are key indicators of quality in oncology care, and guidelines recommend that chemoradiation for …
View article: Assessing differences in healthcare access by HIV status to inform cervical cancer and HIV screening in rural Uganda
Assessing differences in healthcare access by HIV status to inform cervical cancer and HIV screening in rural Uganda Open
Uganda has one of the highest incidence rates of cervical cancer in the world. Although this impacts all women, women living with human immunodeficiency virus (HIV) experience an increased risk for developing cervical cancer. This study ai…
View article: Supplementary Tables from DNA Methylation Epitypes of Burkitt Lymphoma with Distinct Molecular and Clinical Features
Supplementary Tables from DNA Methylation Epitypes of Burkitt Lymphoma with Distinct Molecular and Clinical Features Open
S1. DMRs EBVpos vs CB S2. DMRs EBVneg vs CB S3. Shared DMRs EBV S4. DMRs EBV status S5. Methylation gene corrs EB S6. GO pathways enrichment S7. LPS selected probes S8. Epitype assignment S9. DMRs eptiype S10. DMR gene corrs epitype S11. J…
View article: Supplementary Figures from DNA Methylation Epitypes of Burkitt Lymphoma with Distinct Molecular and Clinical Features
Supplementary Figures from DNA Methylation Epitypes of Burkitt Lymphoma with Distinct Molecular and Clinical Features Open
Supplemental Figure 1. Association between genetic alterations and methylation patterns Supplemental Figure 2. Epitypes characteristics and their relation to other lymphomas. Supplemental Figure 3. Comparison of epitype characteristics in …
View article: Data from DNA Methylation Epitypes of Burkitt Lymphoma with Distinct Molecular and Clinical Features
Data from DNA Methylation Epitypes of Burkitt Lymphoma with Distinct Molecular and Clinical Features Open
The genetic subtypes of Burkitt lymphoma have been defined, but the role of epigenetics remains to be comprehensively characterized. We searched genomic DNA from 218 patients across four continents for recurrent DNA methylation patterns an…
View article: Pragmatic Approach to Hepatocellular Carcinoma Diagnosis in High-Incidence, Resource-Limited Settings in Africa
Pragmatic Approach to Hepatocellular Carcinoma Diagnosis in High-Incidence, Resource-Limited Settings in Africa Open
PURPOSE Hepatocellular carcinoma (HCC) is common and deadly in sub-Saharan Africa, where advanced imaging techniques, such as computerized tomography and magnetic resonance imaging, are scarce. The purpose of this study was to develop a pr…
View article: DNA Methylation Epitypes of Burkitt Lymphoma with Distinct Molecular and Clinical Features
DNA Methylation Epitypes of Burkitt Lymphoma with Distinct Molecular and Clinical Features Open
The genetic subtypes of Burkitt lymphoma have been defined, but the role of epigenetics remains to be comprehensively characterized. We searched genomic DNA from 218 patients across four continents for recurrent DNA methylation patterns an…
View article: Phase I Study of Subcutaneous Rituximab Hyaluronidase Combined With CHOP Chemotherapy for the Treatment of Diffuse Large B-Cell Lymphoma in Uganda
Phase I Study of Subcutaneous Rituximab Hyaluronidase Combined With CHOP Chemotherapy for the Treatment of Diffuse Large B-Cell Lymphoma in Uganda Open
PURPOSE Patients with diffuse large B-cell lymphoma (DLBCL) who are treated in low-resource settings have inferior outcomes compared with those in high-resource settings. Rituximab, an anti-CD20 monoclonal antibody, when combined with chem…
View article: Cervical cancer care at a tertiary oncology facility in Uganda: Comparing daily practice with national treatment targets on cervical cancer control
Cervical cancer care at a tertiary oncology facility in Uganda: Comparing daily practice with national treatment targets on cervical cancer control Open
Objective Treatment of cervical cancer patients in Uganda is hampered by late diagnosis due to the unavailability of timely screening and limited availability of advanced cancer care. This study evaluated the clinical presentation and mana…
View article: Experiences of adult patients with cancer at a specialized cancer care facility in Uganda
Experiences of adult patients with cancer at a specialized cancer care facility in Uganda Open
Background: The experiences of adult cancer patients in low-income countries regarding health care and infrastructure are largely undocumented. This study aimed to describe the experiences of adult men and women receiving treatment at a sp…
View article: Evolution and Recent Radiation Therapy Advancement in Uganda: A Precedent on How to Increase Access to Quality Radiotherapy Services in Low- and Middle-Income Countries
Evolution and Recent Radiation Therapy Advancement in Uganda: A Precedent on How to Increase Access to Quality Radiotherapy Services in Low- and Middle-Income Countries Open
The evolution of radiation therapy in Uganda has been a journey marked by significant milestones and persistent challenges. Since the inception of radiotherapy services in 1988-1989, there has been a concerted effort to enhance cancer trea…
View article: Rearrangements of viral and human genomes at human papillomavirus integration events and their allele-specific impacts on cancer genome regulation
Rearrangements of viral and human genomes at human papillomavirus integration events and their allele-specific impacts on cancer genome regulation Open
Human papillomavirus (HPV) integration has been implicated in transforming HPV infection into cancer. To resolve genome dysregulation associated with HPV integration, we performed Oxford Nanopore Technologies long-read sequencing on 72 cer…
View article: Etiology, Risk Factors, and Outcomes of Bacteremia in Patients With Hematologic Malignancies and Febrile Neutropenia in Uganda
Etiology, Risk Factors, and Outcomes of Bacteremia in Patients With Hematologic Malignancies and Febrile Neutropenia in Uganda Open
Background We determined the etiology, risk factors, and outcomes associated with bacteremia in patients with hematologic malignancies and febrile neutropenia (FN) at the Uganda Cancer Institute (UCI). Methods UCI adult and pediatric inpat…
View article: Assessing how women access healthcare to inform cervical cancer and HIV screening in rural Uganda
Assessing how women access healthcare to inform cervical cancer and HIV screening in rural Uganda Open
Objective This study aims to compare how HIV-positive and HIV-negative women in a remote sub-country in Uganda access health services to inform consideration of potential HIV and HPV-based cervical cancer screening integration at the commu…
View article: Access of Low-Resource Areas to ASCO Quality Initiatives: Initial Experience and Lessons Learned
Access of Low-Resource Areas to ASCO Quality Initiatives: Initial Experience and Lessons Learned Open
With the aim of improving the quality of cancer care globally, ASCO began to offer its quality improvement programs to interested international oncology practices. In this manuscript, we describe the experiences with ASCO quality initiativ…
View article: The regional cancer spectrum in Uganda: a population-based cancer survey by sub-regions (2017–2020)
The regional cancer spectrum in Uganda: a population-based cancer survey by sub-regions (2017–2020) Open
The sub-regional cancer spectrum in Uganda ranges from cervical cancer to breast, esophageal, ovarian and KS in females. Male cancers include prostate, esophageal, KS, liver and stomach cancers. Although the cancer profile is similar in mo…
View article: Highly Heterogeneous Kaposi Sarcoma–Associated Herpesvirus Oral Shedding Kinetics Among People With and Without Kaposi Sarcoma and Human Immunodeficiency Virus Coinfection
Highly Heterogeneous Kaposi Sarcoma–Associated Herpesvirus Oral Shedding Kinetics Among People With and Without Kaposi Sarcoma and Human Immunodeficiency Virus Coinfection Open
Background An improved understanding of oral Kaposi sarcoma–associated herpesvirus (KSHV) viral dynamics could provide insights into transmission risk and guide vaccine development. Methods We evaluated KSHV oral shedding dynamics in Ugand…
View article: Estimating regional and national cancer incidence in Uganda: a retrospective population-based study, 2013–2017
Estimating regional and national cancer incidence in Uganda: a retrospective population-based study, 2013–2017 Open
View article: A Collaborative Partnership Between the Palliative Care Association of Uganda and the Uganda Cancer Institute to Strengthening Cancer Control, Survivorship, and Outcomes Through Research
A Collaborative Partnership Between the Palliative Care Association of Uganda and the Uganda Cancer Institute to Strengthening Cancer Control, Survivorship, and Outcomes Through Research Open
PURPOSE Cancer remains a global health challenge with profound implications on individuals, families, and healthcare systems. The changing face of cancer care needs a holistic strategy that goes beyond conventional treatment modalities. Ug…
View article: Assessing Differences in Healthcare Access for Women in Rural Uganda by HIV Status
Assessing Differences in Healthcare Access for Women in Rural Uganda by HIV Status Open
PURPOSE Although a preventable disease, cervical cancer is a leading cause of cancer death among women in low- and middle-income countries (LMICs). Uganda has one of the highest cervical cancer incidence rates, largely due to limited acces…
View article: Investigating the Healthcare-Seeking Behaviors of Mobile Phone Users to Improve Cervical Cancer Screening in Rural Uganda
Investigating the Healthcare-Seeking Behaviors of Mobile Phone Users to Improve Cervical Cancer Screening in Rural Uganda Open
PURPOSE Cervical cancer is the leading cause of cancer in low- and middle-income countries, despite being a preventable disease. Uganda, which lacks an effective screening program, has one of the highest cervical cancer incidence rates in …
View article: The Economic Burden of Cervical Cancer on Women and Families in Uganda
The Economic Burden of Cervical Cancer on Women and Families in Uganda Open
PURPOSE There is little research on how a cervical cancer diagnosis financially impacts women and their families in low-and middle-income countries, including the burden of out-of-pocket costs. The objective of this analysis is to describe…
View article: Healthcare professionals’ knowledge of and compliance with the ASCO/ESMO/GLIM guidelines for the diagnosis and management of cancer cachexia (CC): the ASSIST-CC baseline findings in Uganda
Healthcare professionals’ knowledge of and compliance with the ASCO/ESMO/GLIM guidelines for the diagnosis and management of cancer cachexia (CC): the ASSIST-CC baseline findings in Uganda Open
This study indicated that the overall objectively correct knowledge of CC diagnosis criteria was inadequate, with a much lower level of awareness about the ASCO/ESMO/GLIM guidelines on CC and a handful of the HCPs have ever assessed the qu…
View article: A randomized control trial to compare mortality in recipients of leucoreduced and non-leucoreduced whole blood transfusion in patients with cancer in Uganda
A randomized control trial to compare mortality in recipients of leucoreduced and non-leucoreduced whole blood transfusion in patients with cancer in Uganda Open
Background Mortality benefit of transfusion with leucoreduced whole blood has not been demonstrated in the sub-Saharan Africa (SSA). We compared mortality in patients with cancer transfused with leucoreduced and non-leucoreduced whole bloo…
View article: Highly heterogeneous human herpes virus-8 oral shedding kinetics among people with and without Kaposi sarcoma and HIV- co-infection
Highly heterogeneous human herpes virus-8 oral shedding kinetics among people with and without Kaposi sarcoma and HIV- co-infection Open
Background An improved understanding of oral human herpesvirus-8 (HHV-8) viral dynamics could provide insights into transmission risk and guide vaccine development. Methods We evaluated HHV-8 oral shedding dynamics in Ugandan adults strati…
View article: Baseline knowledge on risk factors, symptoms and intended behavior of women and men towards screening and treatment of cervical cancer in rural Uganda: a cross-sectional study
Baseline knowledge on risk factors, symptoms and intended behavior of women and men towards screening and treatment of cervical cancer in rural Uganda: a cross-sectional study Open
Background Knowledge of risk factors and symptoms of cervical cancer has been found to promote uptake of screening of cervical cancer. Most interventions targeted women without much involvement of men (husbands/decision makers) who are oft…
View article: Health-related quality of life among adult patients with cancer in Uganda – a cross-sectional study
Health-related quality of life among adult patients with cancer in Uganda – a cross-sectional study Open
Improvement of cancer care in East Africa requires a comprehensive and integrated approach that addresses various challenges specific to the region. Such strategies include investment in healthcare infrastructure, for example, clinical gui…
View article: The distribution of esophageal cancer patients enrolled in care at the Uganda Cancer Institute by sub-regions, districts and ethnicity
The distribution of esophageal cancer patients enrolled in care at the Uganda Cancer Institute by sub-regions, districts and ethnicity Open
Background: There is limited published data regarding the distribution of esophageal cancer patients by sub-regions, districtsand ethnicity in Uganda. Objectives: To study the distribution by sub-regions, districts, ethnicity and sub-regio…
View article: Cancer patterns in Arua district, Uganda: a hospital-based retrospective study
Cancer patterns in Arua district, Uganda: a hospital-based retrospective study Open
There is a high incidence of liver cancer in Arua district. The high levels of cervical, breast and oesophagus cancer were consistent with what is reported by the two PBCRs in Uganda. However, BL could be due to the presence of a BL treatm…
View article: The economic burden of cervical cancer on women in Uganda: Findings from a cross-sectional study conducted at two public cervical cancer clinics
The economic burden of cervical cancer on women in Uganda: Findings from a cross-sectional study conducted at two public cervical cancer clinics Open
There is limited research on how a cervical cancer diagnosis financially impacts women and their families in Uganda. This analysis aimed to describe the economic impact of cervical cancer treatment, including how it differs by socio-econom…