Jacky Y. Suen
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View article: Pressure strain product- a novel load independent parameter for veno-arterial extracorporeal membrane oxygenation weaning
Pressure strain product- a novel load independent parameter for veno-arterial extracorporeal membrane oxygenation weaning Open
Background Our group has previously described a novel speckle-tracking echocardiographic parameter, the "Pressure-Strain product" (PSP). It was investigated in a large animal model of cardiogenic shock, showing a correlation with left vent…
View article: Micro- and Nanoplastic-Induced Respiratory Disease and Dysfunction: A Scoping Review
Micro- and Nanoplastic-Induced Respiratory Disease and Dysfunction: A Scoping Review Open
Background: Human bioaccumulation of micro- and nanoplastics (MNPs) is increasingly being recognised in the aetiology and pathophysiology of human disease. This systematic scoping review aims to provide a comprehensive investigation of stu…
View article: Clinical Course and Outcomes of Cardiogenic Shock in COVID-19 : Insights from COVID-19 Critical Care Consortium
Clinical Course and Outcomes of Cardiogenic Shock in COVID-19 : Insights from COVID-19 Critical Care Consortium Open
Aim: Cardiogenic shock (CS) is a life-threatening condition observed in patients with severe heart diseases. Although COVID-19 is known to cause cardiac complications, the epidemiology and outcomes of CS in COVID-19 patients have not been …
View article: A State-Wide Retrospective Cohort Study Examining Effects of Transfusing Old Blood Products in Vascular Surgical Patients
A State-Wide Retrospective Cohort Study Examining Effects of Transfusing Old Blood Products in Vascular Surgical Patients Open
Introduction: We investigated the effects of transfusing blood products close to the expiration date (i.e., ≥35 days packed red blood cells [PRBCs] and >3 days platelets [PLTs]) on vascular patients. Methods: We retrospectively examined al…
View article: Venous Thromboembolism Risk Assessment Audit
Venous Thromboembolism Risk Assessment Audit Open
Aims: This audit is most relevant to acute inpatients at a general psychiatric hospital (St Ann’s Hospital and Chase Farm Hospital) in which there is high turn over of acutely unwell psychiatric patients being admitted. This set of patient…
View article: Right heart failure after left ventricular assist device implantation: latest insights and knowledge gaps on mechanism and prediction
Right heart failure after left ventricular assist device implantation: latest insights and knowledge gaps on mechanism and prediction Open
Heart failure is a global health concern, with many patients being unresponsive to medical therapies. In end-stage disease, left ventricular assist devices (LVADs) offer an alternative to transplantation, yet their clinical course remains …
View article: Cell-free mitochondrial DNA may predict the risk of post-operative complications and outcomes in surgical aortic valve replacement patients
Cell-free mitochondrial DNA may predict the risk of post-operative complications and outcomes in surgical aortic valve replacement patients Open
Surgical aortic valve replacement (AVR) is the standard of care for severe aortic valve disease; however, post-operative complications continue to pose challenges. Inflammation caused by increased release of cell-free mitochondrial DNA (cf…
View article: Intestinal fatty acid-binding protein as a marker of prognosis and non-occlusive mesenteric ischemia in refractory cardiac arrest patients: a pilot study
Intestinal fatty acid-binding protein as a marker of prognosis and non-occlusive mesenteric ischemia in refractory cardiac arrest patients: a pilot study Open
View article: Micro-nanoplastic induced cardiovascular disease and dysfunction: a scoping review
Micro-nanoplastic induced cardiovascular disease and dysfunction: a scoping review Open
View article: Correction: Effect of early and later prone positioning on outcomes in invasively ventilated COVID-19 patients with acute respiratory distress syndrome: analysis of the prospective COVID-19 critical care consortium cohort study
Correction: Effect of early and later prone positioning on outcomes in invasively ventilated COVID-19 patients with acute respiratory distress syndrome: analysis of the prospective COVID-19 critical care consortium cohort study Open
View article: Streamlining data recording through optical character recognition: a prospective multi-center study in intensive care units
Streamlining data recording through optical character recognition: a prospective multi-center study in intensive care units Open
Background The manual entry of data into large patient databases requires significant resources and time. It is possible that a system that is enhanced with the technology of optical character recognition (OCR) can facilitate data entry, r…
View article: Effects of transfusing older red blood cells on patient outcomes in critical illness: A retrospective cohort study
Effects of transfusing older red blood cells on patient outcomes in critical illness: A retrospective cohort study Open
Background and Objectives Randomized controlled trials have demonstrated morbidity and mortality in critically ill patients are unaffected by transfusing fresh (<7 days old) packed red blood cells (pRBCs); however, there is limited evidenc…
View article: Effect of early and later prone positioning on outcomes in invasively ventilated COVID-19 patients with acute respiratory distress syndrome: analysis of the prospective COVID-19 critical care consortium cohort study
Effect of early and later prone positioning on outcomes in invasively ventilated COVID-19 patients with acute respiratory distress syndrome: analysis of the prospective COVID-19 critical care consortium cohort study Open
View article: A Novel Porcine Model of Bilateral Hindlimb Bypass Graft Surgery Integrating Transit Time Flowmetry
A Novel Porcine Model of Bilateral Hindlimb Bypass Graft Surgery Integrating Transit Time Flowmetry Open
This model may serve as a platform to gain further mechanistic insight into graft failure pathobiology. By combining a bilateral graft model with gold-standard transit time flowmetry, longitudinal experimentation of targeted therapeutic in…
View article: Open-lung ventilation versus no ventilation during cardiopulmonary bypass in an innovative animal model of heart transplantation
Open-lung ventilation versus no ventilation during cardiopulmonary bypass in an innovative animal model of heart transplantation Open
View article: An ovine septic shock model of live bacterial infusion
An ovine septic shock model of live bacterial infusion Open
Background Escherichia coli is the most common cause of human bloodstream infections and bacterial sepsis/septic shock. However, translation of preclinical septic shock resuscitative therapies remains limited mainly due to low-fidelity of …
View article: Neurological Complications and Outcomes in Critically Ill Patients With COVID-19: Results From International Neurological Study Group From the COVID-19 Critical Care Consortium
Neurological Complications and Outcomes in Critically Ill Patients With COVID-19: Results From International Neurological Study Group From the COVID-19 Critical Care Consortium Open
Background In this COVID-19 Critical Care Consortium (CCCC) sub-study, we qualified neurological complications associated with SARS-CoV2 infection. Methods The CCCC is an international, multicenter study. Eligible patients were COVID-19 pa…
View article: Optimizing PEEP levels during injury development is essential to achieve clinically relevant ARDS in animal models
Optimizing PEEP levels during injury development is essential to achieve clinically relevant ARDS in animal models Open
View article: Leukocyte fate in adult patients supported with extracorporeal membrane oxygenation: A retrospective cohort analysis
Leukocyte fate in adult patients supported with extracorporeal membrane oxygenation: A retrospective cohort analysis Open
Introduction Extracorporeal membrane oxygenation (ECMO) is known to influence all blood components. Reduction in leukocyte numbers during ECMO and their slow recovery ECMO have been associated with poorer prognosis. However, few studies on…
View article: Sex differences in the outcome of critically Ill patients with COVID-19 - An international multicenter critical care consortium study
Sex differences in the outcome of critically Ill patients with COVID-19 - An international multicenter critical care consortium study Open
Among patients admitted to ICU for severe COVID-19, males experienced higher severity of illness and more frequent intervention than females. Ultimately, the hazard of death was moderately elevated in males compared to females despite grea…
View article: Impact of Hemoglobin Levels on Composite Cardiac Arrest or Stroke Outcome in Patients With Respiratory Failure Due to COVID-19
Impact of Hemoglobin Levels on Composite Cardiac Arrest or Stroke Outcome in Patients With Respiratory Failure Due to COVID-19 Open
OBJECTIVES: Anemia has been associated with an increased risk of both cardiac arrest and stroke, frequent complications of COVID-19. The effect of hemoglobin level at ICU admission on a composite outcome of cardiac arrest or stroke in an i…
View article: Micro-nanoplastic induced cardiovascular disease and dysfunction: a scoping review
Micro-nanoplastic induced cardiovascular disease and dysfunction: a scoping review Open
Background The human bioaccumulation of micro- and nano-plastics (MNPs) is increasingly being recognised in the aetiology and pathophysiology of human disease. This systematic scoping review provides a comprehensive investigation of studie…
View article: Effects of red blood cell transfusion on patients undergoing cardiac surgery in Queensland – a retrospective cohort study
Effects of red blood cell transfusion on patients undergoing cardiac surgery in Queensland – a retrospective cohort study Open
View article: Worldwide application and valuation of extracorporeal membrane oxygenation support during the COVID-19 pandemic (WAVES)
Worldwide application and valuation of extracorporeal membrane oxygenation support during the COVID-19 pandemic (WAVES) Open
Objective The outcomes of COVID-19 patients on venovenous extracorporeal membrane oxygenation (VV-ECMO) varied. We aim to investigate the variability concerning location and timeframe. We conducted a retrospective analysis of data from 351…
View article: Protocol for high-plex, whole-slide imaging of human formalin-fixed paraffin-embedded tissue using PhenoCycler-Fusion
Protocol for high-plex, whole-slide imaging of human formalin-fixed paraffin-embedded tissue using PhenoCycler-Fusion Open
View article: Stroke in critically ill patients with respiratory failure due to COVID-19: Disparities between low-middle and high-income countries
Stroke in critically ill patients with respiratory failure due to COVID-19: Disparities between low-middle and high-income countries Open
View article: Current trends and latest developments in echocardiographic assessment of right ventricular function: load dependency perspective
Current trends and latest developments in echocardiographic assessment of right ventricular function: load dependency perspective Open
Right ventricle (RV) failure is a common complication of many cardiopulmonary diseases. Since it has a significant adverse impact on prognosis, precise determination of RV function is crucial to guide clinical management. However, accurate…
View article: A novel echocardiographic parameter considering left ventricular afterload during V‐A ECMO support
A novel echocardiographic parameter considering left ventricular afterload during V‐A ECMO support Open
Background Left ventricular stroke work index (LVSWI) and cardiac power index (CPI) account for the haemodynamic load of the left ventricle and are promising prognostic values in cardiogenic shock. However, accurately and non‐invasively me…
View article: Echocardiographic surrogate of left ventricular stroke work in a model of brain stem death donors
Echocardiographic surrogate of left ventricular stroke work in a model of brain stem death donors Open
Background The commonest echocardiographic measurement, left ventricular ejection fraction, can not necessarily predict mortality of recipients following heart transplantation potentially due to afterload dependency. Afterload‐independent …
View article: The Impact of Acute Exercise on Hemostasis and Angiogenesis Mediators in Patients With Continuous-Flow Left Ventricular Assist Devices: A Prospective Observational Pilot Study
The Impact of Acute Exercise on Hemostasis and Angiogenesis Mediators in Patients With Continuous-Flow Left Ventricular Assist Devices: A Prospective Observational Pilot Study Open
Impaired primary hemostasis and dysregulated angiogenesis, known as a two-hit hypothesis, are associated with gastrointestinal (GI) bleeding in patients with continuous-flow left ventricular assist devices (CF-LVADs). Exercise is known to …