Jaclyn M. Einstein
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View article: Integrative CRISPR Screening and RNA Analyses Discover an Essential Role for PUF60 Interactions with 3' Splice Sites in Cancer Progression
Integrative CRISPR Screening and RNA Analyses Discover an Essential Role for PUF60 Interactions with 3' Splice Sites in Cancer Progression Open
RNA-binding proteins (RBPs) are important regulators of post-transcriptional gene expression. Understanding which and how RBPs promote cancer progression is crucial for cancers that lack effective targeted therapies, such as triple negativ…
View article: Integrative CRISPR Screens and RNA-Omics Discover an Essential Role for PUF60-3’ Splice Site Interactions in Cancer Progression
Integrative CRISPR Screens and RNA-Omics Discover an Essential Role for PUF60-3’ Splice Site Interactions in Cancer Progression Open
RNA-binding proteins (RBPs) are important regulators of post-transcriptional gene expression. Understanding which and how RBPs promote cancer progression is crucial for cancers that lack effective targeted therapies such as triple negative…
View article: A CRISPR RNA-binding protein screen reveals regulators of RUNX1 isoform generation
A CRISPR RNA-binding protein screen reveals regulators of RUNX1 isoform generation Open
The proper balance of hematopoietic stem cell (HSC) self-renewal and differentiation is critical for normal hematopoiesis and is disrupted in hematologic malignancy. Among regulators of HSC fate, transcription factors have a well-defined c…
View article: Direct RNA sequencing enables m<sup>6</sup>A detection in endogenous transcript isoforms at base-specific resolution
Direct RNA sequencing enables m<sup>6</sup>A detection in endogenous transcript isoforms at base-specific resolution Open
Direct RNA sequencing holds great promise for the de novo identification of RNA modifications at single-coordinate resolution; however, interpretation of raw sequencing output to discover modified bases remains a challenge. Using Oxford Na…