Jacob A. Lewis
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View article: Surface Plasmon Resonance Based Binding Characterization for Screening RNA-Loaded Lipid Nanoparticles (LNPs): Exploring Species Cross-Reactivity in LNP–Apolipoprotein E Interactions
Surface Plasmon Resonance Based Binding Characterization for Screening RNA-Loaded Lipid Nanoparticles (LNPs): Exploring Species Cross-Reactivity in LNP–Apolipoprotein E Interactions Open
Lipid nanoparticles (LNPs) are an essential delivery platform for nucleic acid payloads that are susceptible to degradation or elimination. Upon administration, a biomolecular corona composed of serum proteins forms around the LNP surface,…
View article: A bioactive supramolecular and covalent polymer scaffold for cartilage repair in a sheep model
A bioactive supramolecular and covalent polymer scaffold for cartilage repair in a sheep model Open
Regeneration of hyaline cartilage in human-sized joints remains a clinical challenge, and it is a critical unmet need that would contribute to longer healthspans. Injectable scaffolds for cartilage repair that integrate both bioactivity an…
View article: Hydrogen Bonding Stiffens Peptide Amphiphile Supramolecular Filaments by Aza-Glycine Residues
Hydrogen Bonding Stiffens Peptide Amphiphile Supramolecular Filaments by Aza-Glycine Residues Open
View article: Supramolecular Exchange among Assemblies of Opposite Charge Leads to Hierarchical Structures
Supramolecular Exchange among Assemblies of Opposite Charge Leads to Hierarchical Structures Open
Hierarchical assemblies of proteins into fibrillar structures occur in both physiologic and pathologic extracellular spaces and often involve interactions between oppositely charged peptide domains. However, the interplay between tertiary …
View article: Gelator Length Precisely Tunes Supramolecular Hydrogel Stiffness and Neuronal Phenotype in 3D Culture
Gelator Length Precisely Tunes Supramolecular Hydrogel Stiffness and Neuronal Phenotype in 3D Culture Open
The brain is one of the softest tissues in the body with storage moduli (G') that range from hundreds to thousands of pascals (Pa) depending upon the anatomic region. Furthermore, pathological processes such as injury, aging and disease ca…
View article: DNA-Peptide Amphiphile Nanofibers Enhance Aptamer Function
DNA-Peptide Amphiphile Nanofibers Enhance Aptamer Function Open
The single stranded DNA oligonucleotides known as aptamers have the capacity to bind proteins and other molecules and offer great therapeutic potential. Further work is required to optimize their function and to diminish their susceptibili…
View article: Reversible self-assembly of superstructured networks
Reversible self-assembly of superstructured networks Open
Chemically reversible hydrogels The dynamic reorganization of some cellular biopolymers in response to signals has inspired efforts to create artificial materials with similar properties. Freeman et al. created hydrogels based on peptide a…
View article: Instructing cells with programmable peptide DNA hybrids
Instructing cells with programmable peptide DNA hybrids Open