Jacob Berardinelli
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View article: Bridging Neuroimaging and Neuropathology: A Comprehensive Workflow for Targeted Sampling of White Matter Lesions
Bridging Neuroimaging and Neuropathology: A Comprehensive Workflow for Targeted Sampling of White Matter Lesions Open
Background and Purpose White matter lesions are common imaging biomarkers associated with aging and neurodegenerative diseases, yet their underlying pathology remains unclear due to limitations in imaging‐based characterization. We aim to …
View article: Bridging Neuroimaging and Neuropathology: A Comprehensive Workflow for Targeted Sampling of White Matter Lesions
Bridging Neuroimaging and Neuropathology: A Comprehensive Workflow for Targeted Sampling of White Matter Lesions Open
Background and Purpose White matter lesions are common imaging biomarkers associated with aging and neurodegenerative diseases, yet their underlying pathology remains unclear due to limitations in imaging-based characterization. We aim to …
View article: Advancements in High‐Resolution MRI Postmortem brain imaging: Histological examination on cells exclusively exhibiting White Matter Hyperintensities made possible using a novel, 3D printed, reusable, imaging container and cutting guide
Advancements in High‐Resolution MRI Postmortem brain imaging: Histological examination on cells exclusively exhibiting White Matter Hyperintensities made possible using a novel, 3D printed, reusable, imaging container and cutting guide Open
Background Employing a custom 60‐channel single‐transmit/32‐channel receive Tic‐Tac‐Toe (TTT) coil in 7T MRI imaging has enhanced the resolution and contrast for identifying White Matter Hyperintensities (WMHs), which are critical markers …
View article: Advancements in High‐Resolution MRI Postmortem brain imaging: Histological examination on cells exclusively exhibiting White Matter Hyperintensities made possible using a novel, 3D printed, reusable, imaging container and cutting guide
Advancements in High‐Resolution MRI Postmortem brain imaging: Histological examination on cells exclusively exhibiting White Matter Hyperintensities made possible using a novel, 3D printed, reusable, imaging container and cutting guide Open
Background Employing a custom 60‐channel single‐transmit/32‐channel receive Tic‐Tac‐Toe (TTT) coil in 7T MRI imaging has enhanced the resolution and contrast for identifying White Matter Hyperintensities (WMHs), which are critical markers …
View article: Correlating hippocampal and amygdala volumes with neuropathological burden in neurodegenerative diseases using 7T postmortem MRI
Correlating hippocampal and amygdala volumes with neuropathological burden in neurodegenerative diseases using 7T postmortem MRI Open
Background High‐resolution and high‐contrast postmortem MRI can unveil structural abnormalities overlooked by antemortem MRI, making it well‐suited for targeted pathology assessments. In community cohorts, limbic‐predominant age‐related TD…
View article: RF shimming strategy for an open 60-channel RF transmit 7T head coil for routine use on the single transmit mode
RF shimming strategy for an open 60-channel RF transmit 7T head coil for routine use on the single transmit mode Open
Purpose To develop an RF shimming approach for operating the 2 nd Generation Tic Tac Toe RF Coil System (60 transmit channels integrated with 32-channel receive insert) for routine use in 7T neuro MRI on the single transmit mode. Methods R…
View article: Correlating hippocampal and amygdala volumes with neuropathological burden in neurodegenerative diseases using 7T postmortem MRI
Correlating hippocampal and amygdala volumes with neuropathological burden in neurodegenerative diseases using 7T postmortem MRI Open
Numerous research groups worldwide have focused on postmortem imaging to bridge the resolution gap between clinical neuroimaging and neuropathology data. We developed a standardized protocol for brain embedding, imaging, and processing, fa…
View article: 7 Tesla Brain MRI: A Paradigm Shifting Technology for Clinical Research in Aging and Dementia Science
7 Tesla Brain MRI: A Paradigm Shifting Technology for Clinical Research in Aging and Dementia Science Open
Background As the usage of MRI for biomedical research increases, an ongoing goal for extending the usefulness of MRIs has been the increase of the magnet’s field strength to 3T, 7T, and beyond. The 7T field strength has recently been give…