Explanipedia

Prognostic impact of SCAI shock severity classes in AMI‐related cardiogenic shock: A sub‐study of the ECLS‐SHOCK Trial Open

Janine Pöss, Jacob C. Jentzer, Steffen Desch, Hans‐Josef Feistritzer, Anne Freund , et al. · 2025

Aims The Society for Cardiovascular Angiography and Interventions (SCAI) Classification provides risk stratification of patients with acute myocardial infarction complicated by cardiogenic shock (AMI‐CS). This sub‐study of the ECLS‐SHOCK t…

Association Between Pressure-Adjusted Heart Rate and In-Hospital Mortality in Cardiogenic Shock Open

Curtis Ginder, Jacob C. Jentzer, Siddharth M. Patel, Erin A. Bohula, Carlos E. Alfonso , et al. · 2025

PAHR, a simple hemodynamic index calculated from vital signs and central venous pressure, is strongly associated with in-hospital mortality in CS.

Emergency Medical Services Response Times in Cardiac Arrest: Less Is More Open

Jacob C. Jentzer, Jon C. Rittenberger · 2025

Noninvasive Hemodynamic Characterization of Cardiohepatic Syndrome in the Cardiac Intensive Care Unit Open

Ahsan Butt, Mitchell Padkins, P. Elliott Miller, Jason N. Katz, Dustin Hillerson , et al. · 2025

Background Patients with cardiohepatic syndrome are at higher risk of adverse outcomes in the cardiac intensive care unit. We hypothesized that cardiohepatic syndrome phenotypes would exhibit differences in their clinical and transthoracic…

An Educational Curriculum for Residents, Advanced Practice Providers, and Fellows in Cardiac Intensive Care Units Open

Anthony Carnicelli, Balimkiz Senman, P. Elliott Miller, Garima Dahiya, Jacob C. Jentzer , et al. · 2025

The contemporary cardiac intensive care unit (CICU) serves as a dynamic educational environment for postgraduate physicians and advanced practice provider trainees. This educational experience, however, can vary substantially between insti…

Outcomes Associated With Renal Replacement Therapy Use and Modality in Cardiogenic Shock Patients Open

Parth Patel, Ahsan Butt, Sean van Diepen, Kianoush Kashani, Dustin Hillerson , et al. · 2025

The lack of evidence-based management in electrical storm: a scoping review Open

Pouya Motazedian, Graeme Prosperi‐Porta, Marie‐Ève Mathieu, Nickolas Beauregard, William Knoll , et al. · 2025

‘July effect’ in management and outcomes of patients admitted with pulmonary embolism in the United States, 2016 to 2021 Open

Mridul Bansal, Aryan Mehta, D. Lynn Morris, Chirag Mehta, Jacob C. Jentzer , et al. · 2025

In this large 6-year US analysis, there were no differences in the outcomes of PE admissions to teaching and nonteaching hospitals in the months of May and July, arguing against the 'July effect.'

Post-infarct effusive-constrictive pericarditis with a percutaneous left ventricular assist device: a case report Open

Jonah Kan, Louise Asleson, Karla Inestroza, Dustin Hillerson, Jacob C. Jentzer · 2025

Background Effusive-constrictive pericarditis (ECP) is a condition where acute pericarditis causes a pericardial effusion and stiffening of the pericardium, which can result in haemodynamic instability due to compression of right-sided car…

Personalizing Mechanical Circulatory Support for Cardiogenic Shock: A Review and Comparison of Current Devices Open

Bradley Fujiuchi, Kevin Benavente, Hafeez Ul Hassan Virk, Mahboob Alam, Jacob C. Jentzer , et al. · 2025

Cardiogenic shock (CS) remains a high morbidity and mortality condition worldwide frequently complicating acute myocardial infarction (AMI) and decompensated heart failure (HF). Within the management of CS, mechanical circulatory support (…

Pulmonary Effective Arterial Elastance by Echocardiography and Mortality in the Cardiac Intensive Care Unit Open

Mitchell Padkins, Garvan C. Kane, Jeremy J. Thaden, Joseph G. Murphy, Michael A. Solomon , et al. · 2025

Gaps and Knowledge in the Contemporary Management of Acute Right Ventricular Failure Open

Paolo Manca, Vincenzo Nuzzi, Massimiliano Mulè, Sergio Sciacca, Matteo Castrichini , et al. · 2025

Acute right ventricular failure (ARVF) is commonly seen in the intensive care unit and constitutes a significant clinical challenge, with associated high in-hospital mortality. Recently, the treatment of ARVF has significantly changed, wit…

Clinical Profiles and Outcomes of Adult Congenital Heart Disease Patients in the Cardiac Intensive Care Unit Open

Luke J. Burchill, Viral Desai, Maan Jokhadar, Cameron Dezfulian, Heidi M. Connolly , et al. · 2025

ACHD patients in the CICU experience high readmission rates and mortality. Tailored treatment strategies are needed to improve outcomes for critical ACHD patients.

Comment: Acute Myocardial Infarction and Stage E Shock: Insights From the RECOVER III Study Open

Harry Peled, Quyen Dau, Jacob C. Jentzer · 2025

Artificial Intelligence ECG Diastolic Dysfunction and Survival in Cardiac Intensive Care Unit Patients Open

Jacob C. Jentzer, Eunjung Lee, Zachi I. Attia, Dustin Hillerson, Garvan C. Kane , et al. · 2025

Background Left ventricular diastolic dysfunction (LVDD) predicts mortality in patients in cardiac intensive care units. An artificial intelligence enhanced ECG (AIECG) algorithm can predict LVDD and mortality in general populations but ha…

VALIDATION OF SCAI SHOCK STAGING IN CRITICALLY ILL MEDICAL INTENSIVE CARE UNIT PATIENTS WITH SEPSIS AND SEPTIC SHOCK Open

Osama Mukhtar, Amos Lal, Jacob C. Jentzer, Kianoush Kashani · 2025

Our results support the use of SCAI shock staging in critically ill medical patients with sepsis and septic shock for risk stratification. We propose that the SCAI shock staging may be used as a universal system for grading the severity of…

Hepatic Biomarker Abnormalities in the Cardiac Intensive Care Unit Open

Ahsan Butt, Mitchell Padkins, Ruben Crespo-Diaz, Dustin Hillerson, Jason N Katz , et al. · 2025

The severity and extent of LFT abnormalities are positively associated with in-hospital and 1-year mortality in CICU patients. Cardiohepatic syndrome is an important predictor of prognosis in CICU patients, and inclusion of LFTs in future …

Echocardiographic Correlates of Hyponatremia in Critically Ill Patients With Heart Failure Open

Anan Younis, Meir Tabi, Kianoush Kashani, Garima Dahiya, Maan Jokhadar , et al. · 2025

CICU patients with HF and hyponatremia have worse hemodynamics reflected by echocardiographic parameters of LV systolic and diastolic function and forward flow, plus worse right ventricular function, with resultant worse clinical outcomes.

Identifying biomarker-driven subphenotypes of cardiogenic shock: analysis of prospective cohorts and randomized controlled trials Open

Sabri Soussi, Tuukka Tarvasmäki, Antoine Kimmoun, Mojtaba Ahmadiankalati, Fériel Azibani , et al. · 2024

Mixed Cardiogenic-Vasodilatory Shock Open

Jacob C. Jentzer, David D. Berg, Meshe Chonde, Garima Dahiya, Andrea Elliott , et al. · 2024

This state-of-the-art review describes the potential etiologies, pathophysiology, and management of mixed shock in the context of a proposed novel classification system. Cardiogenic-vasodilatory shock occurs when cardiogenic shock is compl…

Renal Replacement Therapy in Patients With Cardiogenic Shock: Refining the AEIOUs in Cardiovascular Patients Open

Evan J. Wiens, Jacob C. Jentzer, Patrick Miller, Saraschandra Vallabhajosyula, David D. Berg , et al. · 2024

Cardiogenic shock Open

Enzo Lüsebrink, Leonhard Binzenhöfer, Marianna Adamo, Roberto Lorusso, Alexandre Mebazaa , et al. · 2024

Efficacy of stellate ganglion block in treatment of electrical storm: a systematic review and meta-analysis Open

Pouya Motazedian, Niall Quinn, George A. Wells, Nickolas Beauregard, Eric Lam , et al. · 2024

Electrical storm (ES) is a life-threatening condition of recurrent ventricular arrhythmias (VA) in a short period of time. Percutaneous stellate ganglion blockade (SGB) is frequently used - however the efficacy is undefined. The objective …

Utilization of inpatient palliative care services in cardiac arrest complicating acute pulmonary embolism Open

Aryan Mehta, Mridul Bansal, Chirag Mehta, Ashwin A. Pillai, Salman Allana , et al. · 2024

Palliative care services are used in only 16.8 % of admissions with cardiac arrest complicating pulmonary embolism with significant differences in the populations, suggestive of selective consultation.

Eosinophilic Endomyocarditis After COVID-19 Infection in a Heart Transplant Recipient Open

Sara S. Inglis, Anshul Gupta, Francisco B. Alexandrino, Marie Christine Aubry, Leslie T. Cooper , et al. · 2024

Mortality Risk Stratification Utilizing Artificial Intelligence Electrocardiogram for Hyperkalemia in Cardiac Intensive Care Unit Patients Open

David Harmon, C Heinrich, John Dillon, Rickey E. Carter, Kianoush Kashani , et al. · 2024

AI-ECG-based prediction of hyperkalemia, even with a normal laboratory potassium value, was associated with higher in-hospital mortality and lower 1-year survival in CICU patients. This study demonstrated that AI-ECG probability of hyperka…

Unsupervised machine learning to identify subphenotypes among cardiac intensive care unit patients with heart failure Open

Jacob C. Jentzer, Yogesh N.V. Reddy, Sabri Soussi, Ruben Crespo‐Diaz, Parag C. Patel , et al. · 2024

Aims Hospitalized patients with heart failure (HF) are a heterogeneous population, with multiple phenotypes proposed. Prior studies have not examined the biological phenotypes of critically ill patients with HF admitted to the contemporary…

Premature Acute Myocardial Infarction Treated With Invasive Revascularization: Comparing STEMI With NSTEMI in a Population-Based Study of Young Patients Open

Thomas M. Roston, Vivian Aghanya, Anamaria Savu, Christopher B. Fordyce, Patrick R. Lawler , et al. · 2024

In young patients with AMI, STEMI was a disproportionately male phenomenon and associated with higher mortality at index hospitalization. One-year and 5-year outcomes were similar among STEMI and NSTEMI patients in those discharged alive a…

Clinical Decision Support Opportunities among Clinicians Caring for People Receiving Invasive Mechanical Ventilation: A Cross-sectional Survey Open

Gary E. Weissman, Nicholas S. Bishop, B. Schmid, Vanessa Madden, Romain Pirracchio , et al. · 2024

Treatment decisions for patients receiving invasive mechanical ventilation (IMV) are complex and depend simultaneously on the current ventilator settings, the function of multiple interrelated organ systems, and other treatments. An artifi…

Predicting the unpredictable: a novel application of artificial intelligence in the cardiac intensive care unit Open

Jacob C. Jentzer, Xavier Rosselló · 2024

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