Jacob Clinton
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View article: SMCT1 has a low affinity to PDZ domain containing 1 protein
SMCT1 has a low affinity to PDZ domain containing 1 protein Open
Sodium-coupled monocarboxylate transporter 1 (SMCT1) is a membrane transporter abundantly expressed in colon, kidney, thyroid, brain; and silenced in cancer cells. It transports monocarboxylic acids with little specificity into cells. Base…
View article: Shorter Peptide Nucleic Acid Probes Improve Affibody-Mediated Peptide Nucleic Acid-Based Pretargeting
Shorter Peptide Nucleic Acid Probes Improve Affibody-Mediated Peptide Nucleic Acid-Based Pretargeting Open
Affibody-mediated PNA-based pretargeting shows promise for HER2-expressing tumor radiotherapy. In our recent study, a 15-mer ZHER2:342-HP15 affibody-PNA conjugate, in combination with a shorter 9-mer [177Lu]Lu-HP16 ef…
View article: Conditionally activated affibody-based prodrug targeting EGFR demonstrates improved tumour selectivity
Conditionally activated affibody-based prodrug targeting EGFR demonstrates improved tumour selectivity Open
Safety and efficacy of cancer-targeting treatments can be improved by conditional activation enabled by the distinct milieu of the tumour microenvironment. Proteases are intricately involved in tumourigenesis and commonly dysregulated with…