Jacob E. Dickey
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View article: Leptin engages the lateral hypothalamus to ventral tegmental area circuit to modulate sleep-wake behavior
Leptin engages the lateral hypothalamus to ventral tegmental area circuit to modulate sleep-wake behavior Open
Sleep and metabolism are inextricably linked and mutually affect each other. Leptin is a pivotal regulator of metabolic homeostasis, but its effect on sleep-wake regulation remains elusive. Here we demonstrate that leptin acts on a small s…
View article: Hypomorphism of a Novel Long ERα Isoform Causes Severe Reproductive Dysfunctions in Female Mice
Hypomorphism of a Novel Long ERα Isoform Causes Severe Reproductive Dysfunctions in Female Mice Open
Estrogen receptor alpha (ERα)–mediated estrogen signaling plays a pivotal role in both reproductive and nonreproductive functions. Transcriptional regulation of the ERα gene is highly complex, with multiple transcript variants being differ…
View article: Hypomorphism of a novel long ERα isoform causes severe reproductive dysfunctions in female mice
Hypomorphism of a novel long ERα isoform causes severe reproductive dysfunctions in female mice Open
Estrogen receptor alpha (ERα)-mediated estrogen signaling play a pivotal role in both reproductive and non-reproductive functions. Transcriptional regulation of ERα gene is highly complex, with multiple transcript variants being differenti…
View article: Neuroanatomical organization and functional roles of PVN MC4R pathways in physiological and behavioral regulations
Neuroanatomical organization and functional roles of PVN MC4R pathways in physiological and behavioral regulations Open
Objective The paraventricular nucleus of hypothalamus (PVN) is an integrative center in the brain orchestrating a wide range of physiological and behavioral responses. While the PVN melanocortin 4 receptor (MC4R) signaling (PVN MC4R+ ) is …