Jacob Schaefer
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View article: Sex differences in brain tumor glutamine metabolism reveal sex-specific vulnerabilities to treatment
Sex differences in brain tumor glutamine metabolism reveal sex-specific vulnerabilities to treatment Open
View article: Sex Differences in Brain Tumor Glutamine Metabolism Reveal Sex-Specific Vulnerabilities to Treatment
Sex Differences in Brain Tumor Glutamine Metabolism Reveal Sex-Specific Vulnerabilities to Treatment Open
Summary Sex differences in normal metabolism are well described, but whether they persist in cancerous tissue is unknown. We assessed metabolite abundance in glioblastoma surgical specimens and found that male glioblastomas are enriched fo…
View article: Quantitative rotational-echo double resonance for Carbon-13 spin clusters
Quantitative rotational-echo double resonance for Carbon-13 spin clusters Open
View article: Graphisches Inhaltsverzeichnis: Angew. Chem. 19/2021
Graphisches Inhaltsverzeichnis: Angew. Chem. 19/2021 Open
Research suggests that borate could have mediated the prebiotic synthesis of RNA precursors (ribose, ribonucleosides, and ribonucleotides) in reactions relevant for the origin of life.This minireview provides an overview of recent developm…
View article: REDOR NMR Reveals Multiple Conformers for a Protein Kinase C Ligand in a Membrane Environment
REDOR NMR Reveals Multiple Conformers for a Protein Kinase C Ligand in a Membrane Environment Open
Bryostatin 1 (henceforth bryostatin) is in clinical trials for the treatment of Alzheimer's disease and for HIV/AIDS eradication. It is also a preclinical lead for cancer immunotherapy and other therapeutic indications. Yet nothing is know…
View article: Desleucyl-Oritavancin with a Damaged <scp>d</scp>-Ala-<scp>d</scp>-Ala Binding Site Inhibits the Transpeptidation Step of Cell-Wall Biosynthesis in Whole Cells of <i>Staphylococcus aureus</i>
Desleucyl-Oritavancin with a Damaged <span>d</span>-Ala-<span>d</span>-Ala Binding Site Inhibits the Transpeptidation Step of Cell-Wall Biosynthesis in Whole Cells of <i>Staphylococcus aureus</i> Open
We have used solid-state nuclear magnetic resonance to characterize the exact nature of the dual mode of action of oritavancin in preventing cell-wall assembly in Staphylococcus aureus. Measurements performed on whole cells labeled selecti…
View article: Dual Mode of Action for Plusbacin A<sub>3</sub> in <i>Staphylococcus aureus</i>
Dual Mode of Action for Plusbacin A<sub>3</sub> in <i>Staphylococcus aureus</i> Open
We have used C{F}, N{F}, and N{P} rotational-echo double resonance NMR to determine the location and conformation of 19F and 15N double-labeled plusbacin A3 and of double-labeled deslipo-plusbacin A3
View article: Lactate metabolism is associated with mammalian mitochondria
Lactate metabolism is associated with mammalian mitochondria Open
View article: Exogenous Fatty Acids Are the Preferred Source of Membrane Lipids in Proliferating Fibroblasts
Exogenous Fatty Acids Are the Preferred Source of Membrane Lipids in Proliferating Fibroblasts Open