Jacob Hepkema
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View article: Resolution of a human super-enhancer by targeted genome randomisation
Resolution of a human super-enhancer by targeted genome randomisation Open
Human gene expression is controlled from distance via enhancers, which can form longer ‘super-enhancer’-regions of intense regulatory activity. Whether super-enhancers constitute a separate regulatory paradigm remains unclear, largely due …
View article: Pooled datasets for scover manuscript
Pooled datasets for scover manuscript Open
These are scanpy objects of the pooled datasets associated with our recent work. Please note the datasets are gzipped to save space. The original datasets were obtained through the following sources: Human kidney data: https://www.kidneyce…
View article: Pooled datasets for scover manuscript
Pooled datasets for scover manuscript Open
These are scanpy objects of the pooled datasets associated with our recent work. Please note the datasets are gzipped to save space. The original datasets were obtained through the following sources: Human kidney data: https://www.kidneyce…
View article: Intronization enhances expression of S-protein and other transgenes challenged by cryptic splicing
Intronization enhances expression of S-protein and other transgenes challenged by cryptic splicing Open
The natural habitat of SARS-CoV-2 is the cytoplasm of a mammalian cell where it replicates its genome and expresses its proteins. While SARS-CoV-2 genes and hence its codons are presumably well optimized for mammalian protein translation, …
View article: Predicting the impact of sequence motifs on gene regulation using single-cell data
Predicting the impact of sequence motifs on gene regulation using single-cell data Open
Background Binding of transcription factors (TFs) at proximal promoters and distal enhancers is central to gene regulation. Yet, identification of TF binding sites, also known as regulatory motifs, and quantification of their impact on gen…