Jacob Hudobenko
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View article: Maternal dysbiosis produces long-lasting behavioral changes in offspring
Maternal dysbiosis produces long-lasting behavioral changes in offspring Open
Advanced maternal age (AMA) is defined as a pregnancy in a woman older than 35 years of age. AMA increases the risk for both maternal and neonatal complications, including miscarriage and stillbirth. AMA has also been linked to neurodevelo…
View article: BACE1 regulates expression of Clusterin in astrocytes for enhancing clearance of β-amyloid peptides
BACE1 regulates expression of Clusterin in astrocytes for enhancing clearance of β-amyloid peptides Open
View article: Exploration of C-terminal CX3CL1 for reducing age-dependent neurodegeneration
Exploration of C-terminal CX3CL1 for reducing age-dependent neurodegeneration Open
Owing to the increasing life expectancy, the prevalence of age-dependent neurodegenerative diseases will exert an enormous toll on our aging population, their caregivers and the healthcare system. It is anticipated that numbers of patients…
View article: Additional file 1 of BACE1 regulates expression of Clusterin in astrocytes for enhancing clearance of β-amyloid peptides
Additional file 1 of BACE1 regulates expression of Clusterin in astrocytes for enhancing clearance of β-amyloid peptides Open
Additional file 1: Supplemental Figure S1. Quality control measure of Bace1-/- and Bace1+/+ scRNAseq. (A) Violin plots of data set quality control measurement for nFeature_RNA, nCount_RNA, and percent.mt generated from each ACSA2+-enriched…
View article: The CX3CL1 intracellular domain exhibits neuroprotection via insulin receptor/insulin-like growth factor receptor signaling
The CX3CL1 intracellular domain exhibits neuroprotection via insulin receptor/insulin-like growth factor receptor signaling Open
View article: Bace1 regulates expression of Clusterin in astrocytes for enhancing clearance of β-amyloid peptides
Bace1 regulates expression of Clusterin in astrocytes for enhancing clearance of β-amyloid peptides Open
Background : Abnormal accumulation of amyloid beta peptide (Aβ) in the brain induces a cascade of pathological changes in Alzheimer’s disease (AD), and inhibiting BACE1 to reduce Aβ production is therefore being explored for the treatment …
View article: Microglia depletion increase brain injury after acute ischemic stroke in aged mice
Microglia depletion increase brain injury after acute ischemic stroke in aged mice Open
View article: Young versus aged microbiota transplants to germ-free mice: increased short-chain fatty acids and improved cognitive performance
Young versus aged microbiota transplants to germ-free mice: increased short-chain fatty acids and improved cognitive performance Open
Aging is associated with cognitive decline and decreased concentrations of short-chain fatty acids (SCFAs) in the gut. SCFAs are significant in that they are protective to the gut and other organs. We tested the hypothesis that the aged gu…
View article: Peripherally-sourced myeloid antigen presenting cells increase with advanced aging
Peripherally-sourced myeloid antigen presenting cells increase with advanced aging Open
View article: E-094 Correlation between total thrombus leukocyte count and outcome at discharge post mechanical thrombectomy
E-094 Correlation between total thrombus leukocyte count and outcome at discharge post mechanical thrombectomy Open
Background Ischemic stroke is increasingly being realized to be an inflammatory disease. Post stroke peripheral leukocyte recruitment to the brain has been well studied in preclinical models of ischemic stroke. Limited studies have examine…
View article: Growth differentiation factor-11 supplementation improves survival and promotes recovery after ischemic stroke in aged mice
Growth differentiation factor-11 supplementation improves survival and promotes recovery after ischemic stroke in aged mice Open
Growth differentiation factor (GDF) 11 levels decline with aging. The age-related loss of GDF 11 has been implicated in the pathogenesis of a variety of age-related diseases. GDF11 supplementation reversed cardiac hypertrophy, bone loss, a…
View article: Myeloid-specific TAK1 deletion results in reduced brain monocyte infiltration and improved outcomes after stroke
Myeloid-specific TAK1 deletion results in reduced brain monocyte infiltration and improved outcomes after stroke Open
View article: ISCHEMIC STROKE DAMAGE IS REDUCED BY INHIBITION OF IL-6 SIGNALING WITH TOCILIZUMAB
ISCHEMIC STROKE DAMAGE IS REDUCED BY INHIBITION OF IL-6 SIGNALING WITH TOCILIZUMAB Open
Introduction: Stroke is the leading cause of serious long-term disability and is the 5th leading cause of death causing approximately 130,000 deaths in the United States every year {1}. Stroke is also the 2nd leading cause of death in Amer…
View article: Deletion of the P2X4 receptor is neuroprotective acutely, but induces a depressive phenotype during recovery from ischemic stroke
Deletion of the P2X4 receptor is neuroprotective acutely, but induces a depressive phenotype during recovery from ischemic stroke Open