Jacob I. Sznajder
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View article: Effects of a Multi-Strain Lactic and Propionic Acid Bacteria Inoculant on Silage Quality, Methane Emissions, Milk Composition, and Rumen Microbiome
Effects of a Multi-Strain Lactic and Propionic Acid Bacteria Inoculant on Silage Quality, Methane Emissions, Milk Composition, and Rumen Microbiome Open
Ensiling grass with microbial inoculants is a promising strategy to enhance forage quality, animal performance, and environmental sustainability. This study evaluated the effects of a multi-strain inoculant (Lactobacillus plantarum, L. buc…
View article: Hypercapnia promotes maladaptive airway and vascular remodeling in mice
Hypercapnia promotes maladaptive airway and vascular remodeling in mice Open
CO2 isn't just a gas-it can remodel lungs and worsen COPD, but may be reversible with CO2-lowering therapies.
View article: From Waste to Feed: Enhancing Sustainability in Ruminant Nutrition Through Cashew Apple Utilization – A Review
From Waste to Feed: Enhancing Sustainability in Ruminant Nutrition Through Cashew Apple Utilization – A Review Open
Growing global demand for livestock products has intensified the need for sustainable feed resources in ruminant nutrition, particularly in developing regions. With feed costs comprising up to 75% of production expenses, exploring alternat…
View article: Large language models accurately identify immunosuppression in intensive care unit patients
Large language models accurately identify immunosuppression in intensive care unit patients Open
Objective Rule-based structured data algorithms and natural language processing (NLP) approaches applied to unstructured clinical notes have limited accuracy and poor generalizability for identifying immunosuppression. Large language model…
View article: Sensing molecular carbon dioxide: a translational focus for respiratory disease
Sensing molecular carbon dioxide: a translational focus for respiratory disease Open
The last two decades of research on carbon dioxide have demonstrated that CO 2 is far more than a waste product of aerobic metabolism leading to acidosis and that it elicits biological responses directly via non-pH-dependent molecular inte…
View article: Abstract 1748 Activation of the Integrated Stress Response during hypercapnia prevents alveolar type 2 cells differentiation and induce lung injury
Abstract 1748 Activation of the Integrated Stress Response during hypercapnia prevents alveolar type 2 cells differentiation and induce lung injury Open
View article: Abstract 1432 Elevated Carbon Dioxide Levels Suppress Protein Translation and Modulate Canonical and Non-Canonical Signaling Pathways in Lung Epithelial Cells
Abstract 1432 Elevated Carbon Dioxide Levels Suppress Protein Translation and Modulate Canonical and Non-Canonical Signaling Pathways in Lung Epithelial Cells Open
View article: Nonsuppressible viremia during HIV-1 therapy meets molecular virology
Nonsuppressible viremia during HIV-1 therapy meets molecular virology Open
HIV-1 replication can be suppressed with antiretroviral therapy (ART), but individuals who stop taking ART soon become viremic again. Some people experience extended times of detectable viremia despite optimal adherence to ART. In the issu…
View article: Tissue-resident skeletal muscle macrophages promote recovery from viral pneumonia-induced sarcopenia in normal aging
Tissue-resident skeletal muscle macrophages promote recovery from viral pneumonia-induced sarcopenia in normal aging Open
Sarcopenia, which diminishes lifespan and healthspan in the elderly, is commonly exacerbated by viral pneumonia, including influenza and COVID-19. In a study of influenza A pneumonia in mice, young mice fully recovered from sarcopenia, whi…
View article: Retraction Note: Suppression of inflammation and acute lung injury by Miz1 via repression of C/EBP-δ
Retraction Note: Suppression of inflammation and acute lung injury by Miz1 via repression of C/EBP-δ Open
View article: Author Correction: Profibrotic monocyte-derived alveolar macrophages are expanded in patients with persistent respiratory symptoms and radiographic abnormalities after COVID-19
Author Correction: Profibrotic monocyte-derived alveolar macrophages are expanded in patients with persistent respiratory symptoms and radiographic abnormalities after COVID-19 Open
View article: Profibrotic monocyte-derived alveolar macrophages are expanded in patients with persistent respiratory symptoms and radiographic abnormalities after COVID-19
Profibrotic monocyte-derived alveolar macrophages are expanded in patients with persistent respiratory symptoms and radiographic abnormalities after COVID-19 Open
View article: Corrigendum: miR-182 integrates apoptosis, growth, and differentiation programs in glioblastoma
Corrigendum: miR-182 integrates apoptosis, growth, and differentiation programs in glioblastoma Open
While assembling the figures, incorrect loading controls were used to compose the anti-miR-182 panel (shown at the right in Fig. 2A) and the "GIC-16" Western blot panel in Figure 4C and Supplemental Figure S8B.For Figure 2A, the Hsp70 load…
View article: Orphan Nuclear Receptor Family 4A (NR4A) Members NR4A2 and NR4A3 Selectively Modulate Elements of the Monocyte Response to Buffered Hypercapnia
Orphan Nuclear Receptor Family 4A (NR4A) Members NR4A2 and NR4A3 Selectively Modulate Elements of the Monocyte Response to Buffered Hypercapnia Open
Hypercapnia occurs when the partial pressure of carbon dioxide (CO2) in the blood exceeds 45 mmHg. Hypercapnia is associated with several lung pathologies and is transcriptionally linked to suppression of immune and inflammatory signalling…
View article: Multidisciplinary Center Care for Long COVID Syndrome–A Retrospective Cohort Study
Multidisciplinary Center Care for Long COVID Syndrome–A Retrospective Cohort Study Open
View article: Hypercapnia alters mitochondrial gene expression and acylcarnitine production in monocytes
Hypercapnia alters mitochondrial gene expression and acylcarnitine production in monocytes Open
CO 2 is produced during aerobic respiration. Normally, levels of CO 2 in the blood are tightly regulated but pCO 2 can rise (hypercapnia, pCO 2 > 45 mmHg) in patients with lung diseases, for example, chronic obstructive pulmonary disease (…
View article: Hypercapnia alters stroma-derived Wnt production to limit β-catenin signaling and proliferation in AT2 cells
Hypercapnia alters stroma-derived Wnt production to limit β-catenin signaling and proliferation in AT2 cells Open
Persistent symptoms and radiographic abnormalities suggestive of failed lung repair are among the most common symptoms in patients with COVID-19 after hospital discharge. In mechanically ventilated patients with acute respiratory distress …
View article: Aging is associated with a systemic length-associated transcriptome imbalance
Aging is associated with a systemic length-associated transcriptome imbalance Open
View article: Editorial: Elevated Carbon Dioxide Sensing and Physiologic Effects
Editorial: Elevated Carbon Dioxide Sensing and Physiologic Effects Open
EDITORIAL article Front. Physiol., 27 April 2022Sec. Respiratory Physiology and Pathophysiology Volume 13 - 2022 | https://doi.org/10.3389/fphys.2022.894222
View article: Hypercapnia limits β-catenin-mediated alveolar type 2 cell progenitor function by altering Wnt production from adjacent fibroblasts
Hypercapnia limits β-catenin-mediated alveolar type 2 cell progenitor function by altering Wnt production from adjacent fibroblasts Open
Persistent symptoms and radiographic abnormalities suggestive of failed lung repair are among the most common symptoms in patients with COVID-19 after hospital discharge. In mechanically ventilated patients with ARDS secondary to SARS-CoV-…
View article: Recovering from a pandemic: pulmonary fibrosis after SARS-CoV-2 infection
Recovering from a pandemic: pulmonary fibrosis after SARS-CoV-2 infection Open
Acute manifestations of SARS-CoV-2 infection continue to impact the lives of many across the world. Post-acute sequelae of coronavirus disease 2019 (COVID-19) may affect 10–30% of survivors of COVID-19, and post-acute sequelae of COVID-19 …
View article: Bacterial Superinfection Pneumonia in Patients Mechanically Ventilated for COVID-19 Pneumonia
Bacterial Superinfection Pneumonia in Patients Mechanically Ventilated for COVID-19 Pneumonia Open
Rationale: Current guidelines recommend patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pneumonia receive empirical antibiotics for suspected bacterial superinfection on the basis of weak evidence. Rates o…
View article: TRAF2 Is a Novel Ubiquitin E3 Ligase for the Na,K-ATPase β-Subunit That Drives Alveolar Epithelial Dysfunction in Hypercapnia
TRAF2 Is a Novel Ubiquitin E3 Ligase for the Na,K-ATPase β-Subunit That Drives Alveolar Epithelial Dysfunction in Hypercapnia Open
Several acute and chronic lung diseases are associated with alveolar hypoventilation leading to accumulation of CO 2 (hypercapnia). The β-subunit of the Na,K-ATPase plays a pivotal role in maintaining epithelial integrity by functioning as…
View article: Transcriptional Profiling of Monocytes Deficient in Nuclear Orphan Receptors NR4A2 and NR4A3 Reveals Distinct Signalling Roles Related to Antigen Presentation and Viral Response
Transcriptional Profiling of Monocytes Deficient in Nuclear Orphan Receptors NR4A2 and NR4A3 Reveals Distinct Signalling Roles Related to Antigen Presentation and Viral Response Open
The nuclear receptor sub-family 4 group A (NR4A) family are early response genes that encode proteins that are activated in several tissues/cells in response to a variety of stressors. The NR4A family comprises NR4A1 , NR4A2 and NR4A3 of w…
View article: Maturation of the Na,K-ATPase in the Endoplasmic Reticulum in Health and Disease
Maturation of the Na,K-ATPase in the Endoplasmic Reticulum in Health and Disease Open
The Na,K-ATPase establishes the electrochemical gradient of cells by driving an active exchange of Na + and K + ions while consuming ATP. The minimal functional transporter consists of a catalytic α-subunit and a β-subunit with chaperon ac…
View article: Resetting proteostasis with ISRIB promotes epithelial differentiation to attenuate pulmonary fibrosis
Resetting proteostasis with ISRIB promotes epithelial differentiation to attenuate pulmonary fibrosis Open
Significance Disordered epithelial proteostasis is strongly implicated in the pathobiology of pulmonary fibrosis. We found that a small molecule that specifically restores protein translation by EIF2B during activation of the integrated st…
View article: Dysregulation of ion transport in the lung epithelium infected with SARS-CoV-2
Dysregulation of ion transport in the lung epithelium infected with SARS-CoV-2 Open
Editorial FocusDysregulation of ion transport in the lung epithelium infected with SARS-CoV-2Laura A. Dada, Olga Vagin, and Jacob I. SznajderLaura A. DadaNorthwestern University Feinberg School of Medicine, Chicago, Illinois, Olga VaginDep…
View article: The lung microenvironment shapes a dysfunctional response of alveolar macrophages in aging
The lung microenvironment shapes a dysfunctional response of alveolar macrophages in aging Open
Alveolar macrophages orchestrate the response to viral infections. Age-related changes in these cells may underlie the differential severity of pneumonia in older patients. We performed an integrated analysis of single-cell RNA-Seq data th…
View article: Elevated CO <sub>2</sub> modulates airway contractility
Elevated CO <sub>2</sub> modulates airway contractility Open
Carbon dioxide (CO 2 ), a primary product of oxidative metabolism, can be sensed by eukaryotic cells eliciting unique responses via specific signalling pathways. Severe lung diseases such as chronic obstructive pulmonary disease are associ…
View article: Activation of p21 limits acute lung injury and induces early senescence after acid aspiration and mechanical ventilation
Activation of p21 limits acute lung injury and induces early senescence after acid aspiration and mechanical ventilation Open