Jacob L. Brown
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View article: Endothelial IGF- 1R deficiency disrupts microvascular homeostasis, impairing skeletal muscle perfusion and endurance: implications for age-related sarcopenia
Endothelial IGF- 1R deficiency disrupts microvascular homeostasis, impairing skeletal muscle perfusion and endurance: implications for age-related sarcopenia Open
Aging is associated with a progressive decline in circulating insulin-like growth factor- 1 (IGF- 1) levels in humans, which has been implicated in the pathogenesis of sarcopenia. IGF- 1 is an anabolic hormone that plays a dual role in mai…
View article: Pharmacological reduction of lipid hydroperoxides as a potential modulator of sarcopenia
Pharmacological reduction of lipid hydroperoxides as a potential modulator of sarcopenia Open
We previously reported that elevated expression of phospholipid hydroperoxide glutathione peroxidase 4, an enzyme that regulates membrane lipid hydroperoxides, can mitigate sarcopenia in mice. However, it is still unknown whether a pharmac…
View article: Reactive oxygen species in the pathogenesis of sarcopenia
Reactive oxygen species in the pathogenesis of sarcopenia Open
View article: The nitrone compound OKN-007 delays motor neuron loss and disease progression in the G93A mouse model of amyotrophic lateral sclerosis
The nitrone compound OKN-007 delays motor neuron loss and disease progression in the G93A mouse model of amyotrophic lateral sclerosis Open
Our study investigated the therapeutic potential of OKN-007 in the SOD1 G93A mouse model of amyotrophic lateral sclerosis (ALS). The impact of OKN-007, known for its antioxidant, anti-inflammatory, and neuroprotective properties, was teste…
View article: Neuroprotective treatment with the nitrone compound OKN-007 mitigates age-related muscle weakness in aging mice
Neuroprotective treatment with the nitrone compound OKN-007 mitigates age-related muscle weakness in aging mice Open
View article: The Productivity and Carbon Exchange of an Intensively Managed Pasture in Central Kentucky
The Productivity and Carbon Exchange of an Intensively Managed Pasture in Central Kentucky Open
Intensive pasture management that aims at providing season-long forage while minimizing soil degradation is increasingly becoming an important grazing strategy in Kentucky. Typically, it involves the use of high-yielding warm and cool seas…
View article: Senolytic treatment does not mitigate oxidative stress-induced muscle atrophy but improves muscle force generation in CuZn superoxide dismutase knockout mice
Senolytic treatment does not mitigate oxidative stress-induced muscle atrophy but improves muscle force generation in CuZn superoxide dismutase knockout mice Open
View article: A Unique Presentation of Acute Immune Thrombocytopenia Secondary to Helicobacter pylori Infection
A Unique Presentation of Acute Immune Thrombocytopenia Secondary to Helicobacter pylori Infection Open
View article: Modulation of sarcopenia phenotypes by glutathione peroxidase 4 overexpression in mice
Modulation of sarcopenia phenotypes by glutathione peroxidase 4 overexpression in mice Open
Our laboratory previously showed lipid hydroperoxides and oxylipin levels are elevated in response to loss of skeletal muscle innervation and are associated with muscle pathologies. To elucidate the pathological impact of lipid hydroperoxi…
View article: Breaking Stereotypes: A Unique Presentation of New-Onset Multiple Sclerosis
Breaking Stereotypes: A Unique Presentation of New-Onset Multiple Sclerosis Open
Multiple sclerosis (MS) is a chronic demyelinating disorder resulting in demyelination, neuroaxonal degeneration, and sclerosis. This often-debilitating disease affects young females mainly. Literature describing the pathology and phenotyp…
View article: Elevated phospholipid hydroperoxide glutathione peroxidase (GPX4) expression modulates oxylipin formation and inhibits age-related skeletal muscle atrophy and weakness
Elevated phospholipid hydroperoxide glutathione peroxidase (GPX4) expression modulates oxylipin formation and inhibits age-related skeletal muscle atrophy and weakness Open
View article: Development of skeletal muscle fibrosis in a rodent model of cancer cachexia
Development of skeletal muscle fibrosis in a rodent model of cancer cachexia Open
Cachexia is characterized by losses in lean body mass and its progression results in worsened quality of life and exacerbated outcomes in cancer patients. However, the role and impact of fibrosis during the early stages and development of …
View article: Biological Sex Differences of Fibrosis During the Development of Cancer Cachexia
Biological Sex Differences of Fibrosis During the Development of Cancer Cachexia Open
AIM Cachexia is characterized by losses in lean body mass and its progression results in worsened quality of life and exacerbated outcomes in cancer patients. However, the role and impact of fibrosis during the early stages and development…
View article: Pharmacogenetic Testing and Therapeutic Drug Monitoring Of Sertraline at a Residential Treatment Center for Children and Adolescents: A Pilot Study
Pharmacogenetic Testing and Therapeutic Drug Monitoring Of Sertraline at a Residential Treatment Center for Children and Adolescents: A Pilot Study Open
Background: Sertraline is commonly prescribed to children for the treatment of anxiety and major depressive disorder and is metabolized in part by CYP2C19. While dosing recommendations based on CYP2C19 genotype exist, there is sparse data …
View article: Neuronal deletion of MnSOD in mice leads to demyelination, inflammation and progressive paralysis that mimics phenotypes associated with progressive multiple sclerosis
Neuronal deletion of MnSOD in mice leads to demyelination, inflammation and progressive paralysis that mimics phenotypes associated with progressive multiple sclerosis Open
Neuronal oxidative stress has been implicated in aging and neurodegenerative disease. Here we investigated the impact of elevated oxidative stress induced in mouse spinal cord by deletion of Mn-Superoxide dismutase (MnSOD) using a neuron s…
View article: The Role of Oxylipins in Muscle Atrophy
The Role of Oxylipins in Muscle Atrophy Open
View article: Lipid hydroperoxides and oxylipins are mediators of denervation induced muscle atrophy
Lipid hydroperoxides and oxylipins are mediators of denervation induced muscle atrophy Open
View article: Soil Management and Microclimate Effects on Ecosystem Evapotranspiration of Winter Wheat–Soybean Cropping in Northern Alabama
Soil Management and Microclimate Effects on Ecosystem Evapotranspiration of Winter Wheat–Soybean Cropping in Northern Alabama Open
Nearly all the current winter wheat–soybean cropping systems occurring in the southeastern United States (SE) region are rainfed, as such, precipitation (P) underpins energy partitioning. We investigated, using the eddy covariance techniqu…
View article: Senolytic treatment reduces cell senescence and necroptosis in Sod1 knockout mice that is associated with reduced inflammation and hepatocellular carcinoma
Senolytic treatment reduces cell senescence and necroptosis in Sod1 knockout mice that is associated with reduced inflammation and hepatocellular carcinoma Open
The goal of this study was to test the role cellular senescence plays in the increased inflammation, chronic liver disease, and hepatocellular carcinoma seen in mice null for Cu/Zn‐Superoxide dismutase (Sod1KO). To inhibit senescence, wild…
View article: Effects of PGC-1α overexpression on the myogenic response during skeletal muscle regeneration
Effects of PGC-1α overexpression on the myogenic response during skeletal muscle regeneration Open
The ability of skeletal muscle to regenerate from injury is crucial for locomotion, metabolic health, and quality of life. Peroxisome proliferator-activated receptor-γ coactivator-1α (PGC1A) is a transcriptional coactivator required for mi…
View article: PGC-1α overexpression is not sufficient to mitigate cancer cachexia in either male or female mice
PGC-1α overexpression is not sufficient to mitigate cancer cachexia in either male or female mice Open
Cancer cachexia (CC) accounts for 20%–40% of cancer-related deaths. Mitochondrial aberrations have been shown to precede muscle atrophy in different atrophy models, including cancer. Therefore, this study investigated potential protection …
View article: Effect of hydrostatic pressure on the kinetics of alpha–omega phase transformation in zirconium
Effect of hydrostatic pressure on the kinetics of alpha–omega phase transformation in zirconium Open
A three dimensional (3D) elastoplastic phase-field model, including strain hardening, is employed to study the effect of hydrostatic pressure in the range of 4–9 GPa on the kinetics of alpha–omega phase transformation in zirconium (Zr). Th…
View article: Mitochondrial aberrations during the progression of disuse atrophy differentially affect male and female mice
Mitochondrial aberrations during the progression of disuse atrophy differentially affect male and female mice Open
Background Disuse decreases muscle size and is predictive of mortality across multiple pathologies. Detriments to mitochondrial function are hypothesized to underlie disuse‐induced muscle atrophy. Little data exist on early mechanisms cont…
View article: Tumor burden negatively impacts protein turnover as a proteostatic process in noncancerous liver, heart, and muscle, but not brain
Tumor burden negatively impacts protein turnover as a proteostatic process in noncancerous liver, heart, and muscle, but not brain Open
We present data showing that simultaneously measuring protein synthesis and cell proliferation can help in the understanding of protein turnover as a proteostatic process in response to tumor burden. In some tissues, like hepatic, cardiac,…
View article: Female mice may have exacerbated catabolic signalling response compared to male mice during development and progression of disuse atrophy
Female mice may have exacerbated catabolic signalling response compared to male mice during development and progression of disuse atrophy Open
Background Muscle atrophy is a common pathology associated with disuse, such as prolonged bed rest or spaceflight, and is associated with detrimental health outcomes. There is emerging evidence that disuse atrophy may differentially affect…
View article: Reduced adenosine diphosphate sensitivity in skeletal muscle mitochondria increases reactive oxygen species production in mouse models of aging and oxidative stress but not denervation
Reduced adenosine diphosphate sensitivity in skeletal muscle mitochondria increases reactive oxygen species production in mouse models of aging and oxidative stress but not denervation Open
Background Mitochondrial bioenergetics are sensitive to adenosine diphosphate (ADP) concentration. Reactive oxygen species (ROS) production and respiration [oxygen consumption rate (OCR)] are altered at physiological ADP concentrations (i.…
View article: Development and progression of cancer cachexia: Perspectives from bench to bedside
Development and progression of cancer cachexia: Perspectives from bench to bedside Open
View article: Mitochondrial Function and Protein Turnover in the Diaphragm are Altered in LLC Tumor Model of Cancer Cachexia
Mitochondrial Function and Protein Turnover in the Diaphragm are Altered in LLC Tumor Model of Cancer Cachexia Open
It is established that cancer cachexia causes limb muscle atrophy and is strongly associated with morbidity and mortality; less is known about how the development of cachexia impacts the diaphragm. The purpose of this study was to investig…
View article: Cancer cachexia in a mouse model of oxidative stress
Cancer cachexia in a mouse model of oxidative stress Open
Background Cancer is associated with muscle atrophy (cancer cachexia) that is linked to up to 40% of cancer‐related deaths. Oxidative stress is a critical player in the induction and progression of age‐related loss of muscle mass and weakn…
View article: Neuron‐specific deletion of CuZnSOD leads to an advanced sarcopenic phenotype in older mice
Neuron‐specific deletion of CuZnSOD leads to an advanced sarcopenic phenotype in older mice Open
Age‐associated loss of muscle mass and function (sarcopenia) has a profound effect on the quality of life in the elderly. Our previous studies show that CuZnSOD deletion in mice ( Sod1 −/− mice) recapitulates sarcopenia phenotypes, includi…