Jacob M. Berman
YOU?
Author Swipe
View article: Glutaredoxin 2 is essential for AML survival through mitochondrial permeability transition pore regulation
Glutaredoxin 2 is essential for AML survival through mitochondrial permeability transition pore regulation Open
Acute myeloid leukemia (AML) patients have a poor five-year survival rate highlighting the need for the identification of new approaches to target this disease. AML is highly dependent on glutathione (GSH) metabolism for survival. While th…
View article: De novo design of potent inhibitors of clostridial family toxins
De novo design of potent inhibitors of clostridial family toxins Open
Clostridioides difficile remains a leading cause of hospital-acquired infections, with its primary virulence factor, toxin B (TcdB), responsible for severe colitis and recurrent disease. The closely related toxin, TcsL, from Paeniclostridi…
View article: Identification of Injury-Response State Determinants in Glioblastoma Stem Cells
Identification of Injury-Response State Determinants in Glioblastoma Stem Cells Open
Glioblastoma (GBM) is a common and highly lethal type of primary brain tumor in adults. Therapeutic failure is partly attributed to a fraction of Glioblastoma Stem Cells (GSCs) that show high levels of heterogeneity and plasticity. GSCs ex…
View article: Spermidine metabolism regulates leukemia stem and progenitor cell function through KAT7 expression in patient-derived mouse models
Spermidine metabolism regulates leukemia stem and progenitor cell function through KAT7 expression in patient-derived mouse models Open
Acute myeloid leukemia (AML) is a devastating disease initiated and maintained by a rare subset of cells called leukemia stem cells (LSCs). LSCs are responsible for driving disease relapse, making the development of new therapeutic strateg…
View article: Aneuploidy drives the acquisition of cancer-specific driver genes
Aneuploidy drives the acquisition of cancer-specific driver genes Open
Chromosome instability is highly prevalent in cancer and drives large scale chromosomal imbalances, known as aneuploidies. However, how aneuploidy contributes to tumorigenesis remains difficult to study due to the vast numbers of genes aff…
View article: De novo designed inhibitor confers protection against lethal toxic shock
De novo designed inhibitor confers protection against lethal toxic shock Open
Paeniclostridium sordellii causes a toxic shock syndrome with a mortality rate of nearly 70%, primarily affecting postpartum and post-abortive women. This disease is driven by the production of the P. sordellii lethal toxin, TcsL, for whic…
View article: Polyamines Are Required for AML LSC Function through Their Role in Regulating eIF5A Dependent Protein Synthesis
Polyamines Are Required for AML LSC Function through Their Role in Regulating eIF5A Dependent Protein Synthesis Open
Outcomes for patients with acute myeloid leukemia (AML) remain poor due to the inability of current therapies to fully eradicate disease initiating leukemia stem cells (LSCs) (Shlush et al., 2017). Many studies have demonstrated that LSCs …
View article: Author Correction: In vivo CRISPR screens reveal Serpinb9 and Adam2 as regulators of immune therapy response in lung cancer
Author Correction: In vivo CRISPR screens reveal Serpinb9 and Adam2 as regulators of immune therapy response in lung cancer Open
element EQ normalization beads (Standard BioTools: 201078)".
View article: In vivo CRISPR screens reveal Serpinb9 and Adam2 as regulators of immune therapy response in lung cancer
In vivo CRISPR screens reveal Serpinb9 and Adam2 as regulators of immune therapy response in lung cancer Open
How the genetic landscape governs a tumor’s response to immunotherapy remains poorly understood. To assess the immune-modulatory capabilities of 573 genes associated with altered cytotoxicity in human cancers, here we perform CRISPR/Cas9 s…
View article: Simultaneous inhibition of Sirtuin 3 and cholesterol homeostasis targets acute myeloid leukemia stem cells by perturbing fatty acid β-oxidation and inducing lipotoxicity
Simultaneous inhibition of Sirtuin 3 and cholesterol homeostasis targets acute myeloid leukemia stem cells by perturbing fatty acid β-oxidation and inducing lipotoxicity Open
Outcomes for patients with acute myeloid leukemia (AML) remain poor due to the inability of current therapeutic regimens to fully eradicate disease initiating leukemia stem cells (LSCs). Previous studies have demonstrated that oxidative ph…
View article: A noncoding single-nucleotide polymorphism at 8q24 drives <i>IDH1</i> -mutant glioma formation
A noncoding single-nucleotide polymorphism at 8q24 drives <i>IDH1</i> -mutant glioma formation Open
Establishing causal links between inherited polymorphisms and cancer risk is challenging. Here, we focus on the single-nucleotide polymorphism rs55705857, which confers a sixfold greater risk of isocitrate dehydrogenase ( IDH) –mutant low-…
View article: <i>In vivo</i> CRISPR screens reveal Serpinb9 and Adam2 as regulators of immune therapy response in lung cancer
<i>In vivo</i> CRISPR screens reveal Serpinb9 and Adam2 as regulators of immune therapy response in lung cancer Open
How the genetic landscape of a tumor governs the tumor’s response to immunotherapy remains largely elusive. Here, we established a direct in vivo CRISPR/Cas9 gene editing methodology to assess the immune-modulatory capabilities of 573 puta…
View article: ATP-binding cassette proteins BCRP, MRP1 and P-gp expression and localization in the human umbilical cord
ATP-binding cassette proteins BCRP, MRP1 and P-gp expression and localization in the human umbilical cord Open
1. The umbilical cord is a direct conduit to the fetus hence transporters could have roles in partitioning substances between the maternal-placental-fetal units. Here we determined the expression and localization of the ATP-Binding Cassett…