Jacob P. Bitoun
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View article: ETEC biofilms are regulated by magnesium and lactate bioavailability
ETEC biofilms are regulated by magnesium and lactate bioavailability Open
The prevailing dogma is that enterotoxigenic Escherichia coli (ETEC) use plasmid-borne colonization factors (CFs) to adhere to the intestinal epithelium, where the organisms proliferate and produce their diarrhea-causing virulence factors,…
View article: Multiple factors regulate the expression of sufCDSUB in Streptococcus mutans
Multiple factors regulate the expression of sufCDSUB in Streptococcus mutans Open
Introduction The sufCDSUB gene cluster, encoding the sole iron-sulfur (Fe-S) cluster assembly system in S. mutans , was recently shown to be up-regulated in response to oxidative stressors and Fe limitation. Methods In this study, lucifera…
View article: Heat-Labile Enterotoxin Decreases Macrophage Phagocytosis of Enterotoxigenic Escherichia coli
Heat-Labile Enterotoxin Decreases Macrophage Phagocytosis of Enterotoxigenic Escherichia coli Open
Enterotoxigenic E. coli (ETEC) are endemic in low-resource settings and cause robust secretory diarrheal disease in children less than five years of age. ETEC cause secretory diarrhea by producing the heat-stable (ST) and/or heat-labile (L…
View article: An ALARMINg Type 2 Response in Cystic Fibrosis—The Key to Understanding ABPA?
An ALARMINg Type 2 Response in Cystic Fibrosis—The Key to Understanding ABPA? Open
"An ALARMINg Type 2 Response in Cystic Fibrosis – The Key to Understanding ABPA?." American Journal of Respiratory and Critical Care Medicine, 0(ja), pp. –
View article: Heat-Stable Enterotoxin Secretions Assessed via ICP-MS Reveal Iron-Mediated Regulation of Virulence in CFA/I- and CS6-Expressing ETEC Isolates
Heat-Stable Enterotoxin Secretions Assessed via ICP-MS Reveal Iron-Mediated Regulation of Virulence in CFA/I- and CS6-Expressing ETEC Isolates Open
Enterotoxigenic Escherichia coli (ETEC) are a significant cause of childhood diarrhea in low-resource settings. ETEC are defined by the production of heat-stable enterotoxin (ST) and/or heat-labile enterotoxin (LT), which alter intracellul…
View article: Enterotoxigenic <i>Escherichia coli</i> Enterotoxins Regulate Epithelial to Immune Relay of IL-33 and IL-1Ra Cytokines
Enterotoxigenic <i>Escherichia coli</i> Enterotoxins Regulate Epithelial to Immune Relay of IL-33 and IL-1Ra Cytokines Open
Enterotoxigenic Escherichia coli (ETEC) remain a major cause of diarrheal mortality and morbidity in children in low-resource settings. Few studies have explored the consequences of simultaneous intoxication with heat-stable enterotoxins (…
View article: Changing the locks on intestinal signaling
Changing the locks on intestinal signaling Open
View article: Inhibition of Streptococcus mutans biofilms with bacterial-derived outer membrane vesicles
Inhibition of Streptococcus mutans biofilms with bacterial-derived outer membrane vesicles Open
View article: Streptococcus mutans Lacking sufCDSUB Is Viable, but Displays Major Defects in Growth, Stress Tolerance Responses and Biofilm Formation
Streptococcus mutans Lacking sufCDSUB Is Viable, but Displays Major Defects in Growth, Stress Tolerance Responses and Biofilm Formation Open
Streptococcus mutans appears to possess a sole iron-sulfur (Fe-S) cluster biosynthesis system encoded by the sufCDSUB cluster. This study was designed to examine the role of sufCDSUB in S. mutans physiology. Allelic exchange mutants defici…
View article: Elevated Extracellular cGMP Produced after Exposure to Enterotoxigenic Escherichia coli Heat-Stable Toxin Induces Epithelial IL-33 Release and Alters Intestinal Immunity
Elevated Extracellular cGMP Produced after Exposure to Enterotoxigenic Escherichia coli Heat-Stable Toxin Induces Epithelial IL-33 Release and Alters Intestinal Immunity Open
Enterotoxigenic Escherichia coli (ETEC) is a major diarrheal pathogen in children in low- to middle-income countries. Previous studies identified heat-stable enterotoxin (ST)-producing ETEC as a prevalent diarrheal pathogen in children you…
View article: Burkholderia pseudomallei OMVs derived from infection mimicking conditions elicit similar protection to a live-attenuated vaccine
Burkholderia pseudomallei OMVs derived from infection mimicking conditions elicit similar protection to a live-attenuated vaccine Open
Burkholderia pseudomallei is a Gram-negative, facultative intracellular bacillus that causes the disease melioidosis. B. pseudomallei expresses a number of proteins that contribute to its intracellular survival in the mammalian host. We pr…
View article: Intestinal IL-17R Signaling Controls Secretory IgA and Oxidase Balance in <i>Citrobacter rodentium</i> Infection
Intestinal IL-17R Signaling Controls Secretory IgA and Oxidase Balance in <i>Citrobacter rodentium</i> Infection Open
Type 17 cytokines have been strongly implicated in mucosal immunity, in part by regulating the production of antimicrobial peptides. Using a mouse model of Citrobacter rodentium infection, which causes colitis, we found that intestinal IL-…
View article: Enterotoxigenic Escherichia coli Heat-Stable Toxin Increases the Rate of Zinc Release from Metallothionein and Is a Zinc- and Iron-Binding Peptide
Enterotoxigenic Escherichia coli Heat-Stable Toxin Increases the Rate of Zinc Release from Metallothionein and Is a Zinc- and Iron-Binding Peptide Open
Enterotoxigenic Escherichia coli (ETEC) is a major diarrheal pathogen in children in low- to middle-income countries, deployed military personnel, and travelers to regions of endemicity. The heat-stable toxin (ST) is a small nonimmunogenic…
View article: Intradermal or Sublingual Delivery and Heat-Labile Enterotoxin Proteins Shape Immunologic Responses to a CFA/I Fimbria-Derived Subunit Antigen Vaccine against Enterotoxigenic Escherichia coli
Intradermal or Sublingual Delivery and Heat-Labile Enterotoxin Proteins Shape Immunologic Responses to a CFA/I Fimbria-Derived Subunit Antigen Vaccine against Enterotoxigenic Escherichia coli Open
Enterotoxigenic Escherichia coli (ETEC) is a major cause of infectious diarrhea in children, travelers, and deployed military personnel. As such, development of a vaccine would be advantageous for public health. One strategy is to use subu…
View article: Genome and Functional Characterization of Colonization Factor Antigen I- and CS6-Encoding Heat-Stable Enterotoxin-Only Enterotoxigenic <i>Escherichia coli</i> Reveals Lineage and Geographic Variation
Genome and Functional Characterization of Colonization Factor Antigen I- and CS6-Encoding Heat-Stable Enterotoxin-Only Enterotoxigenic <i>Escherichia coli</i> Reveals Lineage and Geographic Variation Open
Comparative genomics and functional characterization were used to analyze a global collection of CFA/I and CS6 ST-only ETEC isolates associated with human diarrhea, demonstrating differences in the genomic content of CFA/I and CS6 isolates…
View article: Streptococcus mutans Displays Altered Stress Responses While Enhancing Biofilm Formation by Lactobacillus casei in Mixed-Species Consortium
Streptococcus mutans Displays Altered Stress Responses While Enhancing Biofilm Formation by Lactobacillus casei in Mixed-Species Consortium Open
Like Streptococcus mutans, lactobacilli are commonly isolated from carious sites, although their exact role in caries development remains unclear. This study used mixed-species models to analyze biofilm formation by major groups of …
View article: Expression of BrpA in <i>Streptococcus mutans</i> is regulated by <scp>FNR</scp>‐box mediated repression
Expression of BrpA in <i>Streptococcus mutans</i> is regulated by <span>FNR</span>‐box mediated repression Open
Summary Our previous studies showed that brpA in Streptococcus mutans , which encodes a member of the LytR‐CpsA‐Psr family of proteins, can be co‐transcribed with brpB upstream as a bicistronic operon, and the intergenic region also has st…
View article: Deficiency of RgpG Causes Major Defects in Cell Division and Biofilm Formation, and Deficiency of LytR-CpsA-Psr Family Proteins Leads to Accumulation of Cell Wall Antigens in Culture Medium by Streptococcus mutans
Deficiency of RgpG Causes Major Defects in Cell Division and Biofilm Formation, and Deficiency of LytR-CpsA-Psr Family Proteins Leads to Accumulation of Cell Wall Antigens in Culture Medium by Streptococcus mutans Open
Streptococcus mutans is known to possess rhamnose-glucose polysaccharide (RGP), a major cell wall antigen. S. mutans strains deficient in rgpG , encoding the first enzyme of the RGP biosynthesis pathway, were constructed by allelic exchang…
View article: Transcription factor <scp>R</scp>ex in regulation of pathophysiology in oral pathogens
Transcription factor <span>R</span>ex in regulation of pathophysiology in oral pathogens Open
Summary The NAD + and NADH ‐sensing transcriptional regulator Rex is widely conserved across gram‐positive bacteria. Rex monitors cellular redox poise and controls the expression of genes/operons involved in diverse pathways including alte…
View article: PBP1a-Deficiency Causes Major Defects in Cell Division, Growth and Biofilm Formation by Streptococcus mutans
PBP1a-Deficiency Causes Major Defects in Cell Division, Growth and Biofilm Formation by Streptococcus mutans Open
Streptococcus mutans, a key etiological agent of human dental caries, lives almost exclusively on the tooth surface in plaque biofilms and is known for its ability to survive and respond to various environmental insults, including low pH, …